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Legend Biotech is seeking a Scientist as part of the R&D Leadership Development Program based in Philadelphia, PA 

Role Overview

The Early Career Leadership Program at Legend Biotech is a strategic, enterprise-focused development experience designed to accelerate the growth of high-potential professionals early in their careers (3-5 years). Rooted in our commitment to cultivating enterprise-minded, value-driven leaders, this program provides structured rotational exposure, executive mentorship, and real-time business impact across scientific, operational, and corporate functions.

We are seeking an initiative-taking and creative scientist to grow our pipeline efforts. The candidate will be part of our R&D leadership development program at Legend; a leading cell therapy company with a commercial CAR drug product CARVYKTI and an attractive pipeline portfolio. The candidate will be an integral part of our Philadelphia R&D team, whose aim is to research, develop and advance the next generation of cell therapies using innovative in vivo delivery technologies and create novel CAR therapy to treat a wide range of cancer and autoimmune disease indications. This position will focus on in-vivo CAR. The position requires enthusiasm, passion, outstanding skills in the art, diligence, and a desire to create new medicines for patients.

Expertise in immunology and/or oncology is required. The ideal candidate will be a highly motivated individual who enjoys fast paced biotech environment. You thrive in a collaborative work environment and are skilled at advancing multiple projects concurrently. Knowledge of state-of-art immunotherapy and its applications. As part of the Legend Biotech R&D team and under minimal supervision, you will be responsible for timely execution and delivery of projects in our discovery pipeline.

Join us in advancing the frontiers of cell and gene therapy-where your discoveries can redefine treatment paradigms and transform patient outcomes worldwide.

Key Responsibilities

• Lead, design and optimize research with aims of exploring next generation cell therapies using in-vivo CAR-T.
• Contribute to project creation and formation through dissection of published literature to find novel solutions to in-vivo cell therapy problems.
• Isolate immune cells from leukopak or blood of healthy donors or patients and execute the evaluation of in-vivo CAR virus using a battery of in-vitro assays and in-vivo mice models.
• Perform treatment of solid tumor research requiring cell biology techniques including cell culture, transfection, FACS, and cell-based functional assays.
• Package and titer engineered viruses to infect immune cells in vitro and in vivo; Characterize virus particles with protein and PCR based assays; Measure transduction rate using flow and VCN analysis.
• Generate, manage, evaluate, and maintain critical data in a highly organized manner, including the use of ELN.
• Deliver result to meet timeline with accountability through presentation to a wide range of audiences of internal group meetings and other forums.

Requirements

• Recent PhD graduate in Immunology or related life sciences discipline. (within the last 5 years) 
• 3-4 years of experience in the field of cell and gene therapy required, in vivo CAR-T experience preferred
• Extensive experience in immune cell-based analytics and assay development including but not limited to advanced multi-parameter flow-cytometry, immunogenicity assay such as cytotoxicity assay, cytokine release ELISA/MSD multiplex assays.
• Experience with lentivirus particle characterization and quantification using molecular (VCN) and flow-based assays.
• Experience with solid tumor models and in vivo cell-specific gene delivery is a plus.
• Be able to work independently to plan and timely execute research projects
• Deep knowledge of immunology and immunotherapy; a deep understanding of solid tumor models is preferred
• Proficient in advanced gene delivery methods using LVV, VLP or LNP technologies
• Strong experience with lentivirus production, tittering and transduction.
• Working molecular biology and cellular biology knowledge in design and evaluation of modified viral vectors
• Strong multitasking, problem-solving and collaborative skills

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