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Remote Senior Director Clinical Operations Jobs (NOW HIRING)

Omada Health

Senior Director, Clinical Quality

$81K - $111K/yr

Own the operational effectiveness of Omada's clinical quality infrastructure and the quality ... Remote first work from home culture * Flexible Time Off to help you rest, recharge, and connect ...

Greater Good Health

Director, Clinical Performance

$130K - $160K/yr

... or remote/telephonic care coordination operations. You have a true passion for people and outcomes ... Reports to SVP, Clinical Performance * Owns the performance of a portfolio of Clinical Performance ...

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How much do remote senior director clinical operations jobs pay per year?

As of Aug 15, 2026, the average yearly pay for remote senior director clinical operations in the United States is $145,969.00, according to ZipRecruiter salary data. Most workers in this role earn between $102,000.00 and $173,500.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a remote senior director clinical operations?

To thrive as a Remote Senior Director Clinical Operations, you need extensive experience in clinical trial management, regulatory compliance, and leadership, usually backed by an advanced degree in life sciences or healthcare. Familiarity with clinical trial management systems (CTMS), electronic data capture (EDC) platforms, and relevant certifications like PMP or ACRP is highly valuable. Outstanding skills in strategic planning, communication, and cross-functional team leadership differentiate top performers in this role. These competencies ensure effective oversight of complex clinical programs, regulatory adherence, and successful collaboration across remote teams.

What does a remote senior director clinical operations do?

A Remote Senior Director of Clinical Operations oversees clinical trials and research operations, ensuring studies are conducted efficiently and in compliance with regulatory standards—all while working remotely. They lead cross-functional teams, manage budgets, develop operational strategies, and act as a liaison between internal teams and external partners. This leadership role requires a strong background in clinical research, excellent communication skills, and the ability to manage complex projects across multiple locations.

How does a remote senior director clinical operations effectively manage and support geographically dispersed clinical teams?

As a Remote Senior Director Clinical Operations, you will leverage digital collaboration tools, regular virtual meetings, and clear communication protocols to oversee and support teams across multiple locations. Success in this role often involves establishing standardized processes, fostering a collaborative culture despite distance, and ensuring alignment with clinical trial objectives. You will also need to address challenges such as time zone differences and maintaining engagement, while providing leadership on trial execution, compliance, and quality metrics. Building strong relationships with cross-functional partners and implementing robust performance monitoring are essential for driving successful clinical operations remotely.

What is the difference between Remote Senior Director Clinical Operations vs Clinical Project Manager?

AspectRemote Senior Director Clinical OperationsClinical Project Manager
CredentialsAdvanced degrees (e.g., MD, PhD, or PharmD), extensive industry experienceBachelor's or Master's in life sciences, relevant project management certifications
Work EnvironmentStrategic leadership, overseeing multiple projects and teams remotelyManaging individual clinical trials, coordinating project activities
Employer & Industry UsagePharmaceutical companies, biotech firms, CROsPharmaceutical companies, CROs, clinical research organizations

The Remote Senior Director Clinical Operations focuses on strategic oversight and leadership of clinical programs at a high level, often managing teams remotely. In contrast, a Clinical Project Manager handles the day-to-day management of specific clinical trials, ensuring project milestones are met. Both roles require industry experience, but the senior director role involves broader oversight and strategic planning.

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Remote Senior Director Clinical Operations jobs near you
Infographic showing various Remote Senior Director Clinical Operations job openings in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 100% Remote job distribution, with an average salary of $145,969 per year, or $70.2 per hour.

Senior Manager/Director Clinical Operations

Lycia Therapeutics

South San Francisco, CA • On-site, Remote

$169K - $250K/yr

Full-time

Posted 29 days ago

Job description

Lycia Therapeutics is a biotechnology company using its proprietary lysosomal targeting chimera (LYTAC) platform to discover and develop best-in-class therapeutics that degrade extracellular and membrane-bound proteins. These proteins drive a wide range of difficult-to-treat diseases, including autoimmune and inflammatory conditions. Lycia was established in 2019 in collaboration with academic founder and Nobel Laureate Carolyn Bertozzi, Ph.D., professor of chemistry and HHMI investigator at Stanford University. In June, 2026, Lycia Therapeutics completed a $75 million Series D financing to advance its pipeline of LYTAC extracellular protein degraders into the clinic. Lycia is headquartered in South San Francisco.
Visit https://lyciatx.com/ for more information.
Position Summary
The Senior Manager/Director Clinical Operations will be responsible for oversight and management of up to 2 early phase clinical programs in collaboration with the selected Clinical Research Organization (CRO).
Primary Responsibilities:
  • Create and execute clinical operational strategic plans in line with product strategy and resource allocation.
  • Develop study feasibility, cost estimates, input into contracts, work/change orders and analyze tools and processes to support outsourcing efforts.
  • Track clinical program study finances and monthly accruals and review/approve associated clinical site and vendor invoices.
  • Build, develop and train internal staff and external vendors, structure department for enhancing efficiency, and create a highly engaged work environment for attracting and retaining highly qualified clinical operations professionals.
  • Develop and ensure compliance with SOPs and guidelines, FDA regulations and current ICH GCP guidelines.
  • Oversee and maintain the relationships with Contract Research Organizations, vendors, and investigative sites.
  • Participate on clinical operations and study team meetings.
  • Maintain a high level of professional expertise through familiarity of clinical literature, knowledge of therapeutic area, current medical practice and pharmaceutical regulations.

Additional Expectations
  • Although a remote position, it may be necessary to travel to corporate headquarters up to 2 times per year.
  • Ability to travel to clinical sites or to the CRO, as necessary to support trial management.

Qualifications:
  • B.A/B.S required; M.S., PhD, PharmD, MD or other related advanced scientific degree strongly preferred.
  • Minimum of 7 years for manager and 12 years for director level with progressive advancement within clinical operations in the pharmaceutical/biotech industry.
  • Flexible and dynamic interpersonal approach, entrepreneurial by nature, a collaborative team player who works well with physicians, scientists, managers, peers, and staff.
  • Ability to manage in a consensus environment through teamwork, trust and shared expectations, influencing strategic direction of complex global clinical operations issues, solicit information, listen well, persuade others, make important decisions and shape outcomes.

$169,000 - $250,000 a year
The salary range for this position are $169,000-198,000 for Sr. Manager and $206,000-250,000 for Director, which reflects the range across all US locations for which we are hiring. Actual salary will depend on the candidate's geographic location, along with experience, skills, and qualifications.
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Lycia and other biotech companies have recently noticed an increase in email and social media scams targeting job candidates in our industry. Please note Lycia will post any legitimate job openings directly on our website or through our recruitment partner, Lever. If you wish to verify the legitimacy of a job opening, you may contact us.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

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