ZipRecruiter

Log In

1

Protein Design Jobs (NOW HIRING)

Arcadia Science

Protein Designer

Emeryville, CA · On-site

$130K - $180K/yr

Our Validation team does this by closing the design-build-test-learn loop through lab validation across diverse organisms. Read more about our work through our publications. We are seeking a Protein ...

next page

Showing results 1-20

All JobsProtein Design Jobs

Protein Design information

See salary details

$42K

$114.5K

$201.5K

How much do protein design jobs pay per year?

As of Jul 21, 2026, the average yearly pay for protein design in the United States is $114,491.00, according to ZipRecruiter salary data. Most workers in this role earn between $83,500.00 and $144,000.00 per year, depending on experience, location, and employer.

What is the difference between Protein Design vs Protein Engineering?

AspectProtein DesignProtein Engineering
Required CredentialsBiochemistry, Molecular Biology, BioinformaticsBiochemistry, Molecular Biology, Bioinformatics
Work EnvironmentResearch labs, biotech companies, academiaResearch labs, biotech companies, academia
Industry UsageDesigning novel proteins, drug development, synthetic biologyModifying existing proteins for improved function or stability

Protein Design focuses on creating new proteins with specific functions, often using computational methods. Protein Engineering involves modifying existing proteins to enhance or alter their properties. Both roles require similar skills and are used in research, biotech, and pharmaceutical industries, but their goals differ: one designs from scratch, the other optimizes existing proteins.

What are some typical challenges faced by professionals in protein design, and how are they addressed within a team setting?

Professionals in protein design often encounter challenges such as predicting accurate protein folding, ensuring stability, and achieving desired biological activity. These complexities are typically addressed through close collaboration with computational biologists, structural biologists, and experimental scientists. Teams frequently hold cross-functional meetings to troubleshoot issues, share findings, and iterate on design strategies based on laboratory results. This collaborative environment helps leverage diverse expertise and accelerates the development of novel proteins with desired functions.

What are the key skills and qualifications needed to thrive as a Protein Design Scientist, and why are they important?

To thrive as a Protein Design Scientist, you need a strong background in molecular biology, biochemistry, and computational modeling, typically supported by an advanced degree in a relevant field. Proficiency with tools such as Rosetta, PyMOL, and molecular dynamics simulation software, as well as experience with protein expression and purification techniques, is essential. Analytical thinking, problem-solving, and effective communication are important soft skills to drive innovation and collaborate with interdisciplinary teams. These skills are crucial for designing functional proteins, troubleshooting experiments, and advancing research goals in biotechnology and pharmaceutical development.

What is protein design?

Protein design is the process of creating new proteins or modifying existing ones to have specific functions or properties. This can involve using computational tools, laboratory techniques, or a combination of both to predict and engineer amino acid sequences that will fold into desired three-dimensional structures. Protein design is used in various fields, including medicine, biotechnology, and research, to develop novel enzymes, therapeutics, or materials. The field requires a strong understanding of biology, chemistry, and computer science to achieve successful outcomes.
More about Protein Design jobs
What cities are hiring for Protein Design jobs? Cities with the most Protein Design job openings:
What states have the most Protein Design jobs? States with the most job openings for Protein Design jobs include:
What job categories do people searching Protein Design jobs look for? The top searched job categories for Protein Design jobs are:
Protein Design jobs near you
Infographic showing various Protein Design job openings in the United States as of July 2026, with employment types broken down into 88% Full Time, 9% Part Time, and 3% Contract. Highlights an 85% Physical, 4% Hybrid, and 11% Remote job distribution, with an average salary of $114,491 per year, or $55 per hour.
Senior Scientist - Computational Protein Design

Senior Scientist - Computational Protein Design

Amgen

South San Francisco, CA • On-site

Full-time

Re-posted 13 days ago

Job description

Job Summary:
Amgen is a leading biotechnology company focused on serving patients with serious illnesses. In this role, you will develop and deploy automated computational pipelines for large-scale binder design, accelerating the generation of molecules to enhance discovery efforts in protein design.
Responsibilities:
• Develop and automate ML protein design workflows for binder generation
• Build scalable pipelines for designing large libraries of de novo proteins across multiple targets
• Apply computational methods to support multiplexed screening strategies and receptor discovery efforts
• Design and prioritize binders for individual targets and large target panels
• Contribute to shared tools, workflows, and best practices within the protein design community
• Collaborate closely with experimental scientists and data teams to enable rapid validation and iteration
Qualifications:
Required:
• Doctorate degree PhD
• OR PharmD
• OR MD [and relevant post-doc experience in Computational Biology, Structural Biology, Bioengineering, Biophysics, Computer Science, or related discipline with a focus on protein design]
• OR Master’s degree and 3 years of protein design experience
• OR Bachelor’s degree and 5 years of protein design experience
Preferred:
• Ph.D. with postdoc in Computational Biology, Structural Biology, Bioengineering, Biophysics, Computer Science, or related discipline with a focus on protein design.
• Demonstrated experience in computational protein design, including the design of binders such as minibinders and/or antibodies.
• Experience developing automated and scalable computational pipelines for protein design or structural modeling, ideally in high-throughput environments.
• Familiarity with modern AI/ML-driven protein design and structure prediction tools (e.g., AlphaFold, ProteinMPNN, RFdiffusion, or similar frameworks).
• Strong programming skills in Python and/or other scripting languages, with experience building maintainable workflows and automation for large-scale computational experiments.
• Experience working with large protein libraries or multiplexed design strategies, including design filtering, ranking, and diversity optimization.
• Knowledge of protein structure–function relationships, epitope targeting strategies, and protein–protein interaction design principles.
• Experience integrating computational design outputs with experimental validation workflows, including library generation, screening, or directed evolution approaches.
• Familiarity with cloud computing, high-performance computing (HPC), and workflow orchestration tools.
• Experience collaborating in cross-functional teams spanning computational scientists, experimental biologists, and data scientists.
• Strong communication skills and ability to contribute to a collaborative protein design community, including sharing tools, best practices, and design insights.
Company:
Amgen harnesses the best of biology and technology to fight the world’s toughest diseases, and make people’s lives easier, fuller and longer. Founded in 1980, the company is headquartered in Thousand Oaks, USA, with a team of 10001+ employees. The company is currently Late Stage.

Apply