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Protein Biophysics Jobs (NOW HIRING)

Twist Bioscience

Protein Scientist

Portland, OR · On-site

Protein Scientist (Onsite in Wilsonville, OR) Twist Bioscience is expanding our protein ... Implement and troubleshoot workflows for biophysical and functional characterization of IgG and VHH ...

Twist Bioscience

Protein Scientist

Portland, OR · On-site

Protein Scientist (Onsite in Wilsonville, OR) Twist Bioscience is expanding our protein ... Implement and troubleshoot workflows for biophysical and functional characterization of IgG and VHH ...

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How much do protein biophysics jobs pay per hour?

As of Jul 13, 2026, the average hourly pay for protein biophysics in the United States is $42.79, according to ZipRecruiter salary data. Most workers in this role earn between $27.88 and $50.72 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Protein Biophysicist, and why are they important?

To thrive as a Protein Biophysicist, you need a solid background in biology, chemistry, physics, and mathematics, typically with at least a master's or PhD in a related field. Familiarity with tools and techniques such as X-ray crystallography, NMR spectroscopy, mass spectrometry, and computational modeling software is essential. Strong analytical thinking, attention to detail, and effective collaboration and communication skills distinguish successful professionals in this role. These skills ensure accurate experimental design, data interpretation, and the ability to work efficiently within research teams to advance scientific understanding of protein structure and function.

What is the difference between Protein Biophysics vs Structural Biologist?

AspectProtein BiophysicsStructural Biologist
Required CredentialsDegree in Biochemistry, Biophysics, or related field; often PhDDegree in Structural Biology, Biochemistry, or related; often PhD
Work EnvironmentResearch labs, biotech companies, academiaResearch labs, pharmaceutical companies, academia
Industry UsageStudying protein properties, interactions, dynamicsDetermining 3D structures of proteins, complexes
Common Search/ComparisonProtein Biophysics vs Structural Biologist

Protein Biophysics focuses on understanding the physical properties and behaviors of proteins, such as stability and interactions. Structural Biologists primarily determine the 3D structures of proteins to understand their function. While both roles require advanced degrees and work in research environments, Protein Biophysics emphasizes biophysical techniques, whereas Structural Biology centers on structural determination methods like X-ray crystallography and cryo-EM.

What is protein biophysics?

Protein biophysics is a scientific discipline that studies the physical principles and mechanisms underlying the structure, function, dynamics, and interactions of proteins. Researchers in this field use techniques from physics, chemistry, and biology to understand how proteins fold, move, and perform their biological roles. Methods such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy are commonly used to investigate protein properties. This knowledge is essential for drug discovery, understanding diseases, and developing new biomaterials.

What are some common challenges faced by professionals in Protein Biophysics, and how can they be addressed?

Protein biophysicists frequently encounter challenges such as interpreting complex experimental data, maintaining reproducibility in experiments, and managing interdisciplinary collaboration with chemists, biologists, and computational scientists. Staying current with rapidly evolving techniques, such as cryo-EM and single-molecule spectroscopy, is also essential. Addressing these challenges often involves continuous professional development, leveraging collaborative research environments, and utilizing advanced data analysis tools to ensure robust and accurate results.
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Protein Biophysics jobs near you
Senior Research Associate (6 Month Contractor) Biochemistry and Biophysics

Senior Research Associate (6 Month Contractor) Biochemistry and Biophysics

Monte Rosa Therapeutics, Inc

Boston, MA

$45 - $65/hr

Contractor

Posted yesterday

New

Job description

Monte Rosa Therapeutics is seeking a passionate Senior Research Associate with the experience to implement and run biochemical and biophysical characterization assays. This is an exciting opportunity to join a team responsible for the characterization of novel small molecule glue-based degraders to support Monte Rosa’s growing pipeline. The successful candidate will have proven bench level expertise in establishing and performing a range of biochemical and biophysical assays to screen and characterize small molecule compounds and elucidate mechanism of action. The candidate should exhibit excellent communication and collaborative skills for working on cross-functional teams, as well as demonstrate a high degree of independence and organization.


  • Design, develop and implement a variety of kinetic-focused, protein-protein interaction/degradation assays in low and high-throughput settings.
    • Standard assays include TR-FRET, FP, DSF, DLS, and SPR
  • Screen and characterize small molecule compounds and determine the mode of action.
  • Experience in handling and QCing recombinant protein
    • Standard assays include DSF/DLS, FIDA, and analytical SEC
  • Analyze and interpret integrated datasets.
  • Maintain laboratory records, protocols, and summaries.
  • Contribute to laboratory organization and maintenance.
  • Present research plans and results, both within the team and to senior management.

  • BS/MS with at least 2 years pharma/biotech drug discovery laboratory experience in screening.
  • Skill in biochemical and biophysical assays and recombinant protein
  • Experience with various compound screening formats, laboratory instrumentation, and high throughput automation.
  • Experience with sample management processes and instrumentation.
  • Proven ability to work independently and design experiments, troubleshoot, interpret and report large datasets.
  • Highly analytical mind, attention to detail and organization skills are critical.

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