Protein Biophysics Jobs (NOW HIRING)

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work-but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

When it comes to research and development, our goal is to discover and deliver innovative medicines that make life better for people around the world.It'schallenging,expensiveand oftenunpredictable.Yet each outcomeadvancesmedical science anddeepens ourunderstandingofdisease,biologyand chemistry -ultimately bringingnew solutionsone step closer to reality.

Over the course of our history, we have shed light on some of the toughest health care problems known tohumankind- diabetes, heart disease, infectious diseases, neuroscience disorders, cancer and more. We could not pursue this without our research and development team.

Postdoctoral scientists help us continue this pursuit. During your experience you will get:

• Top industry research experience

• Mentoring by some of Lilly's top scientists

• Laboratory andtechnicaltraining andpharmaceutical scienceeducation to further your development

• Collaboration and networking across dozens of postdoctoral scientists and other researchers

We are seeking an ambitious post-doctoral scientist, with strong research and communication skills,in advancinginnovative protein and peptide therapeutics.This role focuses on translating mechanistic insights at the molecular level into robust platform formulation strategies that enable the next generation of biological drug products.In this role, you will:

Position Responsibilities

• Investigate the physical stability of various modalities under different formulation parameters such as pH, concentration, ionic strength, and more.

• Apply a range of biophysical and analytical techniques to characterize molecular interactions within formulations and assess their impact onhigher-order structure,viscosity, rheology, and overall stability.

• Develop mechanistic or kineticmodelslinking formulation and PK/PD-relevant outcomes.

• Stay abreast of current scientific literature and critically evaluate published findings to inform and guide experimental design.

• Collaborate closely with cross-functional teamsacross drugsubstance, drugproduct, structural biology, analytical sciences, biophysical characterization, formulation, computational modeling, and translational pharmacology.

• Identifyareas of key need acrossdrug productdevelopment and champion creative solutions to address those needs.

• Present findings at conferences andpublishin high-quality peer-reviewed journals.

• Prepare technical reports, research summaries, peer-reviewed manuscripts, conference presentations, and invention disclosures asappropriate.

• Maintain awareness of emerging technologies in structural biology, protein biophysics, drug delivery, and pharmaceutical development.

Learning and Development Opportunities

• Develop deepexpertisein protein biophysics, structural biology, formulation science, and translational pharmacology in an industrial R&D environment.

• Gain hands-on exposure to advanced characterization workflows, including solution-state, solid-state, and structural methods.

• Work with a cross-functional mentorship team spanning drug substance, drug product, structural characterization, formulation, and PK/PD interpretation.

• Build a strong publicationandconference-presentationrecord that supports your independent research career.

• Build a strong professional network across Lilly Research Laboratories and the broader protein therapeutics community.

Basic Requirements:

• Ph.D. inrelevant fieldssuch as Biophysics, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, Biomedical Engineering, orcloselyrelated discipline.

• Strong foundationin protein biophysics, structural biology, biologic formulation science, or analytical characterization of peptide/protein therapeutics.

• Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1. Qualifiedapplicants must be authorized to work in the United States on a full-time basis.

Additional Skills/Preferences:

• Hands-on experience with structural and biophysical techniques such asBio-NMR,SAXS (Small Angle X-ray Scattering), neutron scattering, X-ray crystallography,Cryo-EM,SEC-MALS, SLS/DLS, DSC, ITC, mass photometry, HDX-MS, HPLC/UPLC, XRPD, or related methods.

• Experience with crystallization screening, solid-state characterization, or excipient-binding analysis.

• Familiarity with PK/PD concepts, translational pharmacology, or approaches that link in vitro molecular behavior to in vivo performance.

• Self-directed and highly motivatedindividualwhowantsto learn new techniques while continually pursuing research and publication goals.

• Excellent communicator (oral and written) with presentation experience, along with a strong publication record.

• Proficiencyin data analysis and scientific reporting.

Additional Information:

• PositionLocation:This role is an onsite position based atIndianapolis, IN (Lilly Technology Center-North).

• This position is fixed duration employment (FDE) of 2 years, with potential to extend to 3 years, and for maximum of up to 4 years. This position is not full-time regular employment (FTE).

• Opportunities to apply to FTE positions may be available upon completion of the FDE.

• Travel 0-15%.

• Potential exposure to chemicals, allergens, and loud noises.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women's Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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