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Principal Scientist Jobs in Raleigh, NC (NOW HIRING)

IQVIA, Inc.

Principal Statistical Programmer

Durham, NC · On-site

$98K - $273K/yr

Bachelor's or Master's degree in Statistics, Mathematics, Computer Science, Life Sciences, or related field * Extensive experience as a statistical programmer , with demonstrated Principal-level ...

IQVIA LLC

Principal Medical Writier

Durham, NC · On-site

$84 - $211/hr

Bachelor's degree in a scientific, clinical, regulatory, or related field required; advanced degree (e.g., MSc, PhD, PharmD, MD) preferred* Minimum of **7****+ years of experience in medical writing ...

IQVIA

Principal, Patient-Centered Research

Durham, NC · On-site

IQVIA provides scientific services spanning clinical trials, real world evidence, and consulting in ... Role & Responsibilities As a Principal within the PCS team, you will primarily focus within the ...

IQVIA

Principal, Patient-Centered Research

Durham, NC · On-site

IQVIA provides scientific services spanning clinical trials, real world evidence, and consulting in ... Role & Responsibilities As a Principal within the PCS team, you will primarily focus within the ...

Guidehouse

Bioinformatics Scientist

Durham, NC · On-site

Scientist Travel Required: None Clearance Required: Ability to Obtain Public Trust What You Will Do ... principal component, meta-analysis, and related statistical analyses. * Interpret genomic and ...

Guidehouse

Bioinformatics Scientist

Durham, NC · On-site +1

Scientist Travel Required: None Clearance Required: Ability to Obtain Public Trust What You Will Do ... principal component, meta-analysis, and related statistical analyses. * Interpret genomic and ...

IQVIA

Principal Statistical Programmer

Durham, NC · On-site

$98K - $273K/yr

Position Summary We are seeking a Principal Statistical Programmer to provide full endtoend ... Bachelor's or Master's degree in Statistics, Mathematics, Computer Science, Life Sciences, or ...

IQVIA

Principal Statistical Programmer

Durham, NC · On-site

$98K - $273K/yr

Position Summary We are seeking a Principal Statistical Programmer to provide full endtoend ... Bachelor's or Master's degree in Statistics, Mathematics, Computer Science, Life Sciences, or ...

Mars

Principal Project Engineer

Raleigh, NC · On-site

Principal Project Engineer The Principal Project Engineer will be a project manager for the larger ... Bachelor of Science in engineering; an advanced degree in engineering, MBA or PMP certification ...

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Principal Scientist information

See Raleigh, NC salary details

$66.6K

$140K

$185.2K

How much do principal scientist jobs pay per year?

As of Aug 26, 2026, the average yearly pay for principal scientist in Raleigh, NC is $139,988.00, according to ZipRecruiter salary data. Most workers in this role earn between $114,200.00 and $164,300.00 per year, depending on experience, location, and employer.

What is a principal scientist?

A principal scientist takes the lead in research and development on a project. Staff researchers turn to the principal scientist for guidance and direction. As a principal scientist, your job duties include developing the research strategies to be used on the project, directing the research of staff scientists assigned to the project, and monitoring the progress of the study. The principal scientist may also be required to report progress to management and the funding organization.

How does a principal scientist typically collaborate with cross-functional teams in a research organization?

Principal Scientists often serve as key liaisons between research, development, and business units. They lead project teams, facilitate knowledge sharing, and ensure scientific strategies align with organizational goals. Collaboration may involve guiding junior scientists, working with regulatory affairs, and coordinating with manufacturing or quality assurance departments to translate research findings into practical applications. Effective communication and leadership skills are essential, as Principal Scientists must synthesize diverse perspectives to drive projects forward.

What are the key skills and qualifications needed to thrive as a principal scientist, and why are they important?

To thrive as a Principal Scientist, you need advanced expertise in your scientific discipline, a doctoral degree (PhD or equivalent), and a solid track record of research accomplishments. Familiarity with specialized laboratory equipment, data analysis software, and compliance with regulatory standards is typically required. Strong leadership, project management, and communication skills are essential for mentoring teams and collaborating across departments. These competencies enable Principal Scientists to drive innovation, ensure scientific rigor, and deliver impactful research outcomes.

What is the difference between Principal Scientist vs Senior Scientist?

AspectPrincipal ScientistSenior Scientist
Required CredentialsAdvanced degrees (PhD or equivalent), extensive research experienceMaster's or PhD, significant research background
Work EnvironmentLeads research projects, strategic planning, cross-functional collaborationConducts experiments, data analysis, supports project goals
Employer & Industry UsageResearch institutions, biotech, pharma, tech companiesResearch labs, R&D departments in similar industries

The main difference between a Principal Scientist and a Senior Scientist lies in their level of responsibility and scope. Principal Scientists typically lead research initiatives, set strategic directions, and have more experience, while Senior Scientists focus on executing research tasks and supporting project objectives. Both roles require advanced degrees and research expertise, but Principal Scientists hold a higher leadership and strategic role within organizations.

How much does a principal scientist earn?

A principal scientist typically earns between $100,000 and $160,000 annually, depending on experience, industry, and location. They often hold advanced degrees and have extensive expertise in their field, which can influence salary levels.
More about Principal Scientist jobs

What are the most commonly searched types of Principal Scientist jobs in Raleigh, NC?

The most popular types of Principal Scientist jobs in Raleigh, NC are:

What are popular job titles related to Principal Scientist jobs in Raleigh, NC?

For Principal Scientist jobs in Raleigh, NC, the most frequently searched job titles are:

What job categories do people searching Principal Scientist jobs in Raleigh, NC look for?

The top searched job categories for Principal Scientist jobs in Raleigh, NC are:

What cities near Raleigh, NC are hiring for Principal Scientist jobs?

Cities near Raleigh, NC with the most Principal Scientist job openings:

Principal Scientist jobs near you
Infographic showing various Principal Scientist job openings in Raleigh, NC as of August 2026, with employment types broken down into 89% Full Time, 8% Part Time, 1% Temporary, and 2% Contract. Highlights an 91% Physical, 2% Hybrid, and 7% Remote job distribution, with an average salary of $139,988 per year, or $67.3 per hour.

Principal Statistical Programmer

IQVIA, Inc.

Durham, NC • On-site

$98K - $273K/yr

Full-time

Re-posted 6 days ago

IQVIA rating

8.1

Company rating: 8.1 out of 10

Based on 53 frontline employees who took The Breakroom Quiz

62nd of 225 rated it services

Job description

Position Summary
We are seeking a Principal Statistical Programmer to provide full end-to-end statistical programming support across clinical development programs. This role requires deep technical expertise, leadership, and hands-on delivery, covering SDTM, ADaM, TLF development, and regulatory submission support. The Principal Statistical Programmer will serve as a subject matter expert, ensure high-quality deliverables, and contribute to programming standards and best practices.
Key Responsibilities
  • Provide end-to-end statistical programming support for clinical studies from study setup through submission
  • Lead and perform development and validation of:
    • SDTM datasets
    • ADaM datasets
    • Tables, Listings, and Figures (TLFs)
  • Ensure all deliverables are compliant with CDISC standards and regulatory requirements
  • Support regulatory submissions (e.g., FDA, EMA), including define.xml, submission-ready datasets, and reviewer's guides
  • Serve as a Principal-level programmer, providing technical leadership and guidance to other programmers as needed
  • Contribute to and help maintain programming standards, macros, and validation processes
  • Review and approve programming deliverables to ensure accuracy, consistency, and quality
  • Collaborate closely with Biostatistics, Data Management, Clinical Operations, and Regulatory teams
  • Proactively identify risks and propose efficient, compliant solutions within timelines

Required Qualifications
  • Bachelor's or Master's degree in Statistics, Mathematics, Computer Science, Life Sciences, or related field
  • Extensive experience as a statistical programmer, with demonstrated Principal-level responsibilities
  • Strong hands-on experience with:
    • SDTM and ADaM dataset development
    • TLF programming
    • Regulatory submission deliverables
  • Expert proficiency in base SAS and Advanced SAS with good hands on SAS Macros
  • In-depth knowledge of CDISC standards, regulatory guidelines, and submission requirements
  • Proven ability to manage complex studies independently from start to finish

IQVIA is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries. We create intelligent connections to accelerate the development and commercialization of innovative medical treatments to help improve patient outcomes and population health worldwide. Learn more at https://jobs.iqvia.com
IQVIA is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, status as a protected veteran, or any other status protected by applicable law. https://jobs.iqvia.com/eoe
IQVIA is committed to integrity in our hiring process and maintains a zero tolerance policy for candidate fraud. All information and credentials submitted in your application must be truthful and complete. Any false statements, misrepresentations, or material omissions during the recruitment process will result in immediate disqualification of your application, or termination of employment if discovered later, in accordance with applicable law. We appreciate your honesty and professionalism.
The potential base pay range for this role, when annualized, is $98,200.00 - $273,200.00. The actual base pay offered may vary based on a number of factors including job-related qualifications such as knowledge, skills, education, and experience; location; and/or schedule (full or part-time). Dependent on the position offered, incentive plans, bonuses, and/or other forms of compensation may be offered, in addition to a range of health and welfare and/or other benefits.

What IQVIA employees say

Pay

Benefits

Hours and flexibility

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About IQVIA

Sourced by ZipRecruiter

At IQVIA, we are passionate about helping customers and partners improve results and patient outcomes. Everything we do contributes to this vision for creating a healthier world. In today’s healthcare environment, it’s not only about how much data, information, and technology you have at your fingertips – it’s what you do with it. IQVIA is focused on making intelligent connections for customers across the entire healthcare ecosystem to help you drive healthcare forward. Whether that means partnering with novel technology companies to boost patient engagement, leveraging AI & machine learning to accelerate results, or using decentralized trials to reach the right patients wherever they are – we are always looking for smarter ways to move you forward.

Industry

Health care and social assistance

Company size

10,000+ Employees

Headquarters location

Durham, NC, US

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