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Principal Scientist Jobs in Raleigh, NC (NOW HIRING)

Principal Clinical Scientist . This role is responsible for clinical trial strategies within the US and EU regions for Danaher Diagnostics. This role will specifically support Beckman Coulter ...

Principal Data Scientist I

Raleigh, NC · On-site

$118K - $219K/yr

Principal Data Scientist I Are you looking to develop your Data Scientist career? Would you like to be part of a team that innovates using technology? Responsibilities * Acting as a leader for ...

Principal Data Scientist

Raleigh, NC · On-site +1

$147K - $243K/yr

S. Build data science solutions for business challenges including customer propensity, product forecasting, and recommender systems. Use machine learning, data mining, and statistical methods to ...

Principal Medical Writier

Durham, NC · On-site

$84 - $211/hr

Bachelor's degree in a scientific, clinical, regulatory, or related field required; advanced degree (e.g., MSc, PhD, PharmD, MD) preferred* Minimum of **7****+ years of experience in medical writing ...

IQVIA provides scientific services spanning clinical trials, real world evidence, and consulting in ... Role & Responsibilities As a Principal within the PCS team, you will primarily focus within the ...

IQVIA provides scientific services spanning clinical trials, real world evidence, and consulting in ... Role & Responsibilities As a Principal within the PCS team, you will primarily focus within the ...

Showing results 21-40

Principal Scientist information

See Raleigh, NC salary details

$66.6K

$140K

$185.2K

How much do principal scientist jobs pay per year?

As of Sep 4, 2026, the average yearly pay for principal scientist in Raleigh, NC is $139,980.00, according to ZipRecruiter salary data. Most workers in this role earn between $114,200.00 and $164,300.00 per year, depending on experience, location, and employer.

What is a principal scientist?

A principal scientist takes the lead in research and development on a project. Staff researchers turn to the principal scientist for guidance and direction. As a principal scientist, your job duties include developing the research strategies to be used on the project, directing the research of staff scientists assigned to the project, and monitoring the progress of the study. The principal scientist may also be required to report progress to management and the funding organization.

How does a principal scientist typically collaborate with cross-functional teams in a research organization?

Principal Scientists often serve as key liaisons between research, development, and business units. They lead project teams, facilitate knowledge sharing, and ensure scientific strategies align with organizational goals. Collaboration may involve guiding junior scientists, working with regulatory affairs, and coordinating with manufacturing or quality assurance departments to translate research findings into practical applications. Effective communication and leadership skills are essential, as Principal Scientists must synthesize diverse perspectives to drive projects forward.

What are the key skills and qualifications needed to thrive as a principal scientist, and why are they important?

To thrive as a Principal Scientist, you need advanced expertise in your scientific discipline, a doctoral degree (PhD or equivalent), and a solid track record of research accomplishments. Familiarity with specialized laboratory equipment, data analysis software, and compliance with regulatory standards is typically required. Strong leadership, project management, and communication skills are essential for mentoring teams and collaborating across departments. These competencies enable Principal Scientists to drive innovation, ensure scientific rigor, and deliver impactful research outcomes.

What is the difference between Principal Scientist vs Senior Scientist?

AspectPrincipal ScientistSenior Scientist
Required CredentialsAdvanced degrees (PhD or equivalent), extensive research experienceMaster's or PhD, significant research background
Work EnvironmentLeads research projects, strategic planning, cross-functional collaborationConducts experiments, data analysis, supports project goals
Employer & Industry UsageResearch institutions, biotech, pharma, tech companiesResearch labs, R&D departments in similar industries

The main difference between a Principal Scientist and a Senior Scientist lies in their level of responsibility and scope. Principal Scientists typically lead research initiatives, set strategic directions, and have more experience, while Senior Scientists focus on executing research tasks and supporting project objectives. Both roles require advanced degrees and research expertise, but Principal Scientists hold a higher leadership and strategic role within organizations.

How much does a principal scientist earn?

A principal scientist typically earns between $100,000 and $160,000 annually, depending on experience, industry, and location. They often hold advanced degrees and have extensive expertise in their field, which can influence salary levels.

What are the most commonly searched types of Principal Scientist jobs in Raleigh, NC?

The most popular types of Principal Scientist jobs in Raleigh, NC are:

What cities near Raleigh, NC are hiring for Principal Scientist jobs?

Cities near Raleigh, NC with the most Principal Scientist job openings:

Infographic showing various Principal Scientist job openings in Raleigh, NC as of August 2026, with employment types broken down into 88% Full Time, 10% Part Time, 1% Temporary, and 1% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $139,980 per year, or $67.3 per hour.

$143K - $229K/yr

Other

Medical, Retirement, PTO

Posted 29 days ago


Blue Cross and Blue Shield of North Carolina rating

7.8

Company rating: 7.8 out of 10

Based on 13 frontline employees who took The Breakroom Quiz

197th of 315 rated insurance


Job description

Job Description

The Principal Data Scientist will serve as the principal lead to provide accurate and quality analyses that translate data in sound organizational decisions. In this role you will provide strategic thought leadership and partner with other functional areas to deliver collaborative work products that align with divisional and enterprise strategy. You will own delivery of multiple large and/or complex data science and engineering projects.

What You'll Do

  • Lead in the development and testing of hypotheses across all functional data sets

  • Lead requirements gathering sessions with business and technical staff to distill technical requirement from business requests

  • Define and implement integrated data models, allowing integration of data from multiple sources

  • Design and develop scalable, efficient data pipeline processes to handle data ingestion, cleansing, transformation, integration, and validation

  • Define and implement data stores based on system requirements and consumer requirements

  • Design and develop models to understand and solve multiple complex business solutions using a variety of methods including data mining, statistical analysis, predictive modeling and analysis, stochastic modeling, pattern recognition, probability analysis, and network analysis

  • Design and implement production models leveraging technologies such Python, and R

  • Leverage existing data sets and engineer new data sets including development of SQL queries, data integration and resolution of data quality issues

  • Apply advanced conceptual understanding of Big Data systems to data set engineering and analytic model implementation

  • Lead development and reviews of complex analytic models and algorithms

  • Identify actionable insights, suggest recommendations, and influence business direction by effectively communicating results to cross functional groups

  • Document and test analytic processes including performance and thorough data validation and verification

  • Engage with enterprise business areas to incorporate feedback into audit process including but not limited to Payment Integrity, SIU, Provider, Behavioral Health, Med Policy, Claims, Pharmacy
  • Articulate analytic methods and drive business outcomes with responsible business areas
  • Consult with executive level leadership across the organization- with responsibility to drive CoC ideation for Commercial and Medicare
  • Informally lead other analysts and synthesize information and make recommendations to executive leadership
What You Bring
  • Bachelor's degree or advanced degree (where required)

  • 8+ years of experience in related field.

  • In lieu of degree, 10+ years of experience in related field.

  • Strong Analytic/Data Science skills:

  • Experience with Snowflake

  • Experience building AI Agents

  • Understand Bell curve analysis

  • Incorporate Industry benchmarks into analysis

  • Perform outlier detection

  • Strong healthcare experience with Payment Integrity/FWA business knowledge is required

  • understanding of FWA concepts, CMS guidelines, Medical/Reimbursement Policy are all strongly preferred

Salary Range

At Blue Cross NC, we take great pride in a fair and equitable compensation package that reflects market-price and our starting salaries are typically planned near the middle of the range listed. Compensation decisions are driven by factors including experience and training, specialized skill sets, licensure and certifications and other business and organizational needs.Our base salary is part of a robust Total Rewards package that includes an Annual Incentive Bonus*, 401(k) with employer match, Paid Time Off (PTO), and competitive health benefits and wellness programs.

*Based on annual corporate goal achievement and individual performance.

$143,616.00 - $229,786.00

Skills

Big Data, Complex Data Analysis, Data Analysis, Data Engineering, Data Mining, Data Modeling Techniques, Data Science, Data Visualization, Machine Learning (ML), Predictive Analytics, Predictive Modeling, Python (Programming Language), Statistical Analysis, Statistical Models

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JOB ALERT FRAUD: We have become aware of scams from individuals, organizations, and internet sites claiming to represent Blue Cross and Blue Shield of North Carolina in recruitment activities in return for disclosing financial information. Our hiring process does not include text-based conversations or interviews and never requires payment or fees from job applicants. All our career opportunities are published on https://bcbsnc.wd5.myworkdayjobs.com/en-US/BCBSNC. If you have already provided your personal information that you suspect is fraudulent activity, please report it to your local authorities. Any fraudulent activity should be reported to: HR.Staffing@BCBSNC.com.


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