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Postdoctoral Position In Peptide Synthesis Jobs (NOW HIRING)

Amgen

Process Development Senior Scientist

Thousand Oaks, CA · On-site

$96K - $131K/yr

Serve as a technical expert and keep current in the field of solid phase peptide synthesis * Work ... Application deadline Amgen does not have an application deadline for this position; we will ...

Amgen

Process Development Senior Scientist

Cambridge, MA

$100K - $136K/yr

Serve as a technical expert and keep current in the field of solid phase peptide synthesis * Work ... Application deadline Amgen does not have an application deadline for this position; we will ...

JobRx, Inc.

Global Head of Drug Substance

Cambridge, MA · On-site

$230 - $360/hr

Your new position Zealand Pharma is looking for a Global Head of Drug Substance - Senior Director ... Deep expertise in solid‑phase and/or liquid‑phase peptide synthesis, purification, and process ...

Zealand Pharma

Global Head of Drug Substance

Cambridge, MA · On-site

$251K - $307K/yr

Your new position Zealand Pharma is looking for a Global Head of Drug Substance - Senior Director ... Deep expertise in solid-phase and/or liquid-phase peptide synthesis, purification, and process ...

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How much do postdoctoral position in peptide synthesis jobs pay per year?

As of Aug 17, 2026, the average yearly pay for postdoctoral position in peptide synthesis in the United States is $85,959.00, according to ZipRecruiter salary data. Most workers in this role earn between $56,000.00 and $116,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in a postdoctoral position in peptide synthesis?

To thrive in a Postdoctoral Position in Peptide Synthesis, you need a PhD in chemistry, biochemistry, or a related field with a solid background in peptide synthesis and purification techniques. Experience with analytical tools such as HPLC, mass spectrometry, and peptide synthesizers, as well as familiarity with relevant software, is typically required. Strong problem-solving abilities, attention to detail, and effective collaboration and communication skills help you excel in multidisciplinary research environments. These skills ensure the successful design, synthesis, and analysis of peptides, contributing to impactful research outcomes.

What are some common challenges faced in a postdoctoral position in peptide synthesis, and how can they be addressed?

Postdoctoral researchers in peptide synthesis often encounter challenges such as optimizing synthetic routes for complex peptides, managing the purification of difficult sequences, and troubleshooting low yields or unexpected side reactions. These hurdles can be addressed by staying current with the latest literature, using advanced purification techniques like HPLC, and collaborating closely with other chemists or biochemists in the lab. Open communication with mentors and team members also helps in brainstorming solutions and sharing best practices, fostering a collaborative environment that is essential for overcoming technical obstacles.

What is a postdoctoral position in peptide synthesis?

A Postdoctoral Position in Peptide Synthesis is a research-focused role for individuals who have recently completed their Ph.D. in chemistry, biochemistry, or a related field. The primary responsibility is to design, synthesize, and characterize peptides for various scientific studies, often in drug discovery or biomedical research. Postdocs in this area may also be involved in developing new synthetic methodologies, analyzing experimental data, and publishing their findings. These roles typically provide training and experience necessary for an academic or industry career in chemical and biological sciences.
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Postdoctoral Position In Peptide Synthesis jobs near you
Infographic showing various Postdoctoral Position In Peptide Synthesis job openings in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 94% In-person, and 6% Remote job distribution, with an average salary of $85,959 per year, or $41.3 per hour.

Principal Scientist, Peptide Therapeutics

Genentech, Inc.

South San Francisco, CA • On-site

$143K - $265K/yr

Full-time

Re-posted 5 days ago

Genentech rating

8.8

Company rating: 8.8 out of 10

Based on 22 frontline employees who took The Breakroom Quiz

11th of 86 rated pharmaceutical

Job description

The Opportunity
We are seeking a creative and highly motivated Principal Scientist, Medicinal Chemist to join our R&D team. This is a primarily lab-based, technical leadership position within the Peptide Therapeutics department. In this lab-based leadership role, you will combine hands-on synthetic expertise with strategic oversight, driving the discovery and optimization of peptide therapeutics across the full development lifecycle.
Key Responsibilities
1. Synthetic Execution & Lab Leadership
  • Primary Bench Driver: Execute the multi-step synthesis of peptides, peptidomimetics, and novel, non-commercial building blocks or scaffolds.
  • Synthetic Mastery: Utilize expert-level skills in solid-phase peptide synthesis, solution-phase organic chemistry, and specialized macrocyclization or ligation strategies.
  • Analytical Rigor: Personally oversee high-resolution analysis (HPLC, Mass Spec, NMR) to confirm compound identity and ensure the delivery of high-purity materials.

2. Strategic Design & Technology Innovation
  • Apply conformational analysis, structure-based design, and computational modeling (e.g., MD simulations) to optimize potency, stability, and pharmacokinetics. Drive polycyclization strategies to improve drug-like properties.
  • Lead Optimization: Implement strategic SAR plans and Multi-Parameter Optimization to advance candidates from early hits through to IND-enabling studies.

3. Collaborative Leadership
  • Lead multidisciplinary project teams, serving as the technical bridge between Peptide Therapeutics, Research Biology, Drug Discovery, and Therapeutic Areas.
  • Supervise and mentor junior scientists directly at the bench, fostering a culture of technical excellence and scientific innovation.

Who You Are
  • Education: Ph.D. in Organic or Medicinal Chemistry (or related field) with 3+ years of relevant postdoctoral or industry experience.
  • Synthetic Expert: Proven mastery of both SPPS (manual and automated) and complex solution-phase organic synthesis.
  • Design Savvy: Deep knowledge of macrocyclic peptides, various routes of administration (IV, SC, PO), and library-based screening (e.g., mRNA display, AS/MS, OBOC).
  • Computationally Proficient: Experienced in using software (Schrödinger, MOE, Maestro) for molecular dynamics, conformational sampling, and AI/ML-driven sequence optimization.
  • Effective Communicator: Ability to present complex technical data and strategic roadmaps to global cross-functional stakeholders.

Relocation benefits are available for this posting.
The expected salary range for this position based on the primary location of California is $143,200 to $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

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About Genentech

Sourced by ZipRecruiter

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Industry

Scientific research and development services

Company size

10,000+ Employees

Headquarters location

South San Francisco, CA, US

Year founded

1976

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