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Phage Display Jobs (NOW HIRING)

Systimmune

Director, Protein Engineering

Redmond, WA · On-site

$180K - $240K/yr

Experience leading display campaigns alongside complementary discovery modalities (phage display, immunization-derived repertoires, in silico/AI-based design) is strongly preferred. * Excellent ...

SystImmune, Inc

Director, Protein Engineering

Redmond, WA · On-site

$180K - $240K/yr

Experience leading display campaigns alongside complementary discovery modalities (phage display, immunization-derived repertoires, in silico/AI-based design) is strongly preferred. * Excellent ...

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Phage Display information

What are the key skills and qualifications needed to thrive in the Phage Display position, and why are they important?

To thrive in a Phage Display role, you need a solid background in molecular biology, protein engineering, and laboratory techniques, often supported by a degree in biology, biochemistry, or a related field. Familiarity with tools such as PCR, ELISA, DNA sequencing, and bioinformatics software is typically required, and experience with phage libraries or related certifications can be advantageous. Strong analytical thinking, meticulous attention to detail, and effective teamwork and communication skills help candidates excel in this position. These competencies are vital for designing experiments, troubleshooting complex protocols, and collaborating on scientific research projects.

What are some typical day-to-day responsibilities for someone working in Phage Display?

Professionals in Phage Display spend much of their day designing, conducting, and troubleshooting experiments involving the selection and screening of phage-displayed peptide or antibody libraries. This often includes molecular cloning, bacterial culture, protein expression and purification, and data analysis. Collaboration with multidisciplinary teams—such as bioinformaticians, chemists, and project managers—is common, as is documenting results and preparing reports or presentations. The role may also involve adapting protocols for new targets, contributing to scientific publications, and maintaining meticulous laboratory records.

What is a Phage Display job?

A Phage Display job typically involves working with bacteriophage-based techniques to screen peptides, proteins, or antibodies for binding to specific targets. Scientists in this field use phage libraries to identify high-affinity binders for drug discovery, diagnostics, or therapeutic development. Responsibilities may include library construction, screening, sequencing, and data analysis. The role is often found in biotech or pharmaceutical companies, as well as academic research labs.

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Phage Display jobs near you
Associate Scientist, Display Technologies

Associate Scientist, Display Technologies

BigHat Biosciences

San Mateo, CA

$120K - $135K/yr

Full-time

Medical, Dental, Vision, Retirement

Posted 19 days ago

Key responsibilities

  • Support R&D projects advancing display technologies to expand antibody discovery capabilities and feed machine learning models.

  • Lead in the construction and quality control of phage and yeast display libraries using standard molecular biology techniques.

  • Execute phage and yeast display selections and analyze results to discover and engineer antibodies with desired therapeutic properties.

Job description

Description
The role: BigHat Biosciences is seeking a curious and motivated Associate Scientist to join the Display Technologies team. This individual will contribute to BigHat’s antibody discovery and engineering efforts and help generate high-quality data to improve BigHat’s machine learning models using display technologies, working closely with senior scientists and cross-functional teams.
*At BigHat we believe in titles that commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate. 

Key Responsibilities
  • Support R&D projects advancing display technologies at BigHat that expands BigHat's antibody discovery capabilities and feed its ML models.
  • Lead in the construction and QC of phage and yeast display libraries across diverse antibody formats (VHH, scFv, Fab) using standard molecular biology techniques (PCR, molecular cloning, electroporation).
  • Execute phage and yeast display selections using naive and affinity and stability maturation libraries to discover and engineer antibodies with desired therapeutic properties.
  • Express, purify, and characterize display-derived molecules using assays including ELISA, flow cytometry, BLI/SPR, CE-SDS, and others.
  • Analyze selection results and contribute to discussions on next steps and future experimental design.
  • Collaborate with BigHat’s Data Science and Machine Learning teams to inform library design and interpret selection data for model training.
  • Present experimental plans and results during regular meetings with manager and science teams.
  • Maintain thorough records using LIMS and electronic notebooks.

Skills Knowledge and Expertise
  • BS or MS in Biochemistry, Molecular Biology, Bioengineering, or a related field.
  • 4+ years of hands-on laboratory experience (academic or industry); relevant internship or research experience welcome.
  • Familiarity with general molecular biology techniques (PCR, molecular cloning, gel electrophoresis).
  • Exposure to antibody biology, display technologies (phage or yeast), and protein expression.
  • Demonstrated ability to follow protocols carefully, troubleshoot experiments, and maintain detailed lab records.
  • Effective time management and clear written and verbal communication skills.
  • Collaborative, team-oriented mindset with an eagerness to learn in a fast-paced startup environment.
  • Nice-to-haves include experience with flow cytometry, ELISA, or other binding assays, and familiarity with NGS or automation platforms.

Total Rewards
The salary estimated for this position is $120,000 - $135,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
What BigHat Offers:
  • Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
  • Dental, and vision coverage through Guardian
  • Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
  • 401(k) with company match 
  • DTO, two weeks of company-wide shutdown, and 12 company holidays
  • Paid parental leave