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Microglia Research Jobs (NOW HIRING)

Duke University

POSTDOCTORAL ASSOCIATE

Durham, NC · On-site

Composed of more than 2,600 faculty physicians and researchers, nearly 2,000 students, and more ... and even microglia. Building on this work, we seek to harness the power of this new tool to ...

Mount Sinai Hospital

Postdoctoral Fellow-MSH

Manhattan, NY · On-site

$53K - $73K/yr

Mindur will perform research at the Cardiovascular Research Center. The project will primarily ... microglia/macrophages and through driving the differentiation of monocytes into monocyte-derived ...

Retro

Lead Histotechnologist

Redwood City, CA · On-site

$110K - $135K/yr

You'll be the primary histologist supporting multiple scientific programs - including our Microglia ... Biotech, pharmaceutical, or academic research histology core environments * Image analysis or ...

Retro

Lead Histotechnologist

Redwood City, CA

$110K - $135K/yr

You'll be the primary histologist supporting multiple scientific programs - including our Microglia ... Biotech, pharmaceutical, or academic research histology core environments * Image analysis or ...

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Microglia Research information

What are some typical challenges faced when conducting microglia research in a laboratory setting?

One common challenge in microglia research is maintaining the viability and purity of microglial cultures, as these cells are highly sensitive and can be easily activated by external stimuli. Researchers often need to troubleshoot protocols frequently and adjust to variability in cell responses. Additionally, distinguishing microglia from other glial cells in mixed cultures or tissue samples can require advanced techniques such as flow cytometry or immunostaining. Collaboration with neuroscientists, immunologists, and bioinformaticians is also essential to interpret complex data and advance projects efficiently.

What is microglia research?

Microglia research is the scientific study of microglia, which are specialized immune cells found in the central nervous system. Researchers in this field investigate how microglia function in both healthy and diseased brains, including their roles in neuroinflammation, brain development, and neurodegenerative diseases like Alzheimer's. The aim is to better understand how microglia contribute to brain health and to identify potential therapeutic targets for neurological conditions.

What are the key skills and qualifications needed to thrive in Microglia Research, and why are they important?

To thrive in Microglia Research, you need a strong background in neuroscience, cellular/molecular biology, and experimental design, typically with a PhD or relevant advanced degree. Familiarity with technical tools such as immunohistochemistry, flow cytometry, imaging techniques (e.g., confocal microscopy), and data analysis software (e.g., ImageJ, GraphPad Prism) is crucial. Strong analytical thinking, attention to detail, and collaborative communication skills are essential soft skills in this role. These competencies ensure rigorous experimental work, insightful data interpretation, and effective teamwork in advancing understanding of microglial function and pathology.
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Infographic showing various Microglia Research job openings in the United States as of July 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution.
Postdoctoral Scientist - Neuropsychiatry

Postdoctoral Scientist - Neuropsychiatry

Eli Lilly and Company

Boston, MA • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 16 days ago

Eli Lilly and Company rating

8.8

Company rating: 8.8 out of 10

Based on 63 frontline employees who took The Breakroom Quiz

8th of 74 rated pharmaceutical

Job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work-but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.
Are you looking to make a significant difference by advancing our understanding of psychiatric diseases such as schizophrenia and major depressive disorder? If so, this might be the right role for you. We are seeking an ambitious postdoctoral scientist with strong research and communication skills to contribute to a high-visibility research program at the intersection of human iPSC biology, neuroscience, and functional genomics.
Your work will contribute to establishing a cutting-edge human iPSC-derived co-culture platform to study neuron-astrocyte interactions in psychiatric conditions - a powerful approach to uncovering disease mechanisms and identifying novel therapeutic targets. In this role, you will:
  • Develop and characterize human iPSC-derived tri- and quad-culture models containing excitatory neurons, inhibitory neurons, astrocytes, and potentially microglia to study neuron-glia interactions in psychiatry-relevant contexts.
  • Apply multielectrode array (MEA) electrophysiology and automated patch-clamp (autopatcher) to assess network dynamics and single-cell excitability in iPSC co-culture models.
  • Utilize mRNA lipid nanoparticle (LNP) delivery for transient gene overexpression and perturbation (including CRISPR knockout/interference) in iPSC cultures - a novel approach in this field.
  • Investigate functional consequences of psychiatric risk gene variants on astrocyte function and neuron-astrocyte signaling.
  • Perform single-cell or single-nucleus RNA-Seq from co-culture models and apply pathway analysis to identify disease-associated gene modules and hub genes.
  • Integrate multi-modal datasets (electrophysiological, morphological, transcriptomic) to establish mechanistic links between genetic perturbations and neuronal network dysfunction.
  • Design and execute rescue experiments using pharmacological and genetic strategies to validate therapeutic hypotheses.
  • Collaborate with cross-functional teams including computational biology, bioinformatics, medicinal chemistry, and external academic partners.
  • Present findings at major scientific conferences (e.g., Society for Neuroscience, ACNP) and publish in high-impact peer-reviewed journals as first author.
  • Maintain external awareness and learning to benefit the organization. Identify areas of key need to champion creative solutions.

Basic Qualifications
  • PhD in Neuroscience, Cell Biology, Molecular Biology, or a closely related field.
  • Demonstrated experience with at least one of the following: human iPSC culture and directed differentiation, primary neuronal culture, electrophysiology (patch-clamp or MEA), or neuron-glia biology.
  • Strong publication record demonstrating scientific productivity and independence.
  • Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.

Additional Information
  • This position is not permanent and requires US citizenship or permanent resident status. It is for a fixed duration of two years with potential to extend to three years and for a maximum of up to four years. You will have opportunities to apply for full-time positions after your duration is complete.
  • Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Additional Skills/Preferences
  • Self-directed and highly motivated individual who wants to learn new techniques while continually pursuing research and publication goals.
  • Excellent communicator (oral and written) with presentation experience, along with a strong publication record.
  • Interest in psychiatric disease mechanisms and translational neuroscience research.
  • Experience with human iPSC culture, neural differentiation protocols, and co-culture system development.
  • Experienced with electrophysiology platforms including multielectrode array (MEA) and/or automated patch-clamp systems.
  • Experience with mRNA or lipid nanoparticle (LNP) delivery systems is a plus.
  • Familiarity with CRISPR-based gene editing tools (knockout, CRISPRi/a, base editing).
  • Proficiency in high-content imaging, immunofluorescence, and automated image analysis.
  • Experience with single-cell RNA-Seq data acquisition, bioinformatics analysis, and pathway enrichment tools.
  • Strong analytical skills and ability to integrate multi-modal datasets.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women's Initiative for Leading at Lilly (WILL).
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$58,000 - $123,200
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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About Eli Lilly

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Eli Lilly, based in Indianapolis, IN, US, is one of the pioneers in the pharmaceutical industry with a rich history dating back to 1876. This global pharmaceutical company focuses on discovering, developing, manufacturing and selling pharmaceutical products in approximately 120 countries. The company's product categories include endocrinology, oncology, cardiovascular, neuroscience, and immunology. Having invested over $9 billion in research and development in the past decade, Eli Lilly is also committed to creating high-quality medicines that meet real needs. As a recipient of several awards and recognitions, Eli Lilly is known for its focus on life-saving research and drug development. Their mission is to make medicines that help people live longer, healthier, and more active lives.

Industry

Pharmaceutical product wholesalers

Company size

10,000+ Employees

Headquarters location

Indianapolis, IN, US

Year founded

1876

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