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Microglia Research Jobs (NOW HIRING)

WuXi AppTec

Scientist II

San Diego, CA

$80K - $104K/yr

... as other research and development services. We are seeking a highly motivated and versatile ... microglia, neuron-astrocyte, multi-lineage systems) to study disease mechanisms. • Support ...

WuXi AppTec

Scientist II

San Diego, CA

$80K - $104K/yr

... as other research and development services. We are seeking a highly motivated and versatile ... microglia, neuron-astrocyte, multi-lineage systems) to study disease mechanisms. • Support ...

WuXi AppTec

Scientist II

San Diego, CA · On-site

$80K - $104K/yr

... as other research and development services. We are seeking a highly motivated and versatile ... microglia, neuron-astrocyte, multi-lineage systems) to study disease mechanisms. • Support ...

Mount Sinai Hospital

Postdoctoral Fellow-MSH

Manhattan, NY · On-site

$72K - $80K/yr

Mindur will perform research at the Cardiovascular Research Center. The project will primarily ... microglia/macrophages and through driving the differentiation of monocytes into monocyte-derived ...

University of California, Irvine

Lab Asst. 1

Irvine, CA · On-site

$25.75/hr

... microglia in the CNS. Another significant emphasis has been on translational research and therapy development, with programs aimed at gene silencing of dominant disease protein expression (as ...

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What are some typical challenges faced when conducting microglia research in a laboratory setting?

One common challenge in microglia research is maintaining the viability and purity of microglial cultures, as these cells are highly sensitive and can be easily activated by external stimuli. Researchers often need to troubleshoot protocols frequently and adjust to variability in cell responses. Additionally, distinguishing microglia from other glial cells in mixed cultures or tissue samples can require advanced techniques such as flow cytometry or immunostaining. Collaboration with neuroscientists, immunologists, and bioinformaticians is also essential to interpret complex data and advance projects efficiently.

What is microglia research?

Microglia research is the scientific study of microglia, which are specialized immune cells found in the central nervous system. Researchers in this field investigate how microglia function in both healthy and diseased brains, including their roles in neuroinflammation, brain development, and neurodegenerative diseases like Alzheimer's. The aim is to better understand how microglia contribute to brain health and to identify potential therapeutic targets for neurological conditions.

What are the key skills and qualifications needed to thrive in Microglia Research, and why are they important?

To thrive in Microglia Research, you need a strong background in neuroscience, cellular/molecular biology, and experimental design, typically with a PhD or relevant advanced degree. Familiarity with technical tools such as immunohistochemistry, flow cytometry, imaging techniques (e.g., confocal microscopy), and data analysis software (e.g., ImageJ, GraphPad Prism) is crucial. Strong analytical thinking, attention to detail, and collaborative communication skills are essential soft skills in this role. These competencies ensure rigorous experimental work, insightful data interpretation, and effective teamwork in advancing understanding of microglial function and pathology.
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Microglia Research jobs near you
Infographic showing various Microglia Research job openings in the United States as of May 2026, with employment types broken down into 7% As Needed, 86% Part Time, and 7% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution.

Postdoctoral Fellow, Hahn Lab - Brain Aging

Calico

South San Francisco, CA • On-site

$95K/yr

Full-time

Posted 19 days ago

Job description

Who We Are
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
The Calico Postdoctoral Fellowship Program
We are seeking ambitious early career scientists to join us in our mission to increase our understanding of the biology that controls human aging. This is a unique opportunity for individuals to distinguish themselves in aging research, deepen scientific training, and develop research independence.
The Postdoctoral Fellowship is a fixed-term educational assignment (three years with a potential fourth year extension) with rolling start dates. Postdoctoral Fellows are fully integrated into Calico's labs and community.
The program is designed to train individuals to become independent investigators in an academic or industry setting upon successful completion of the assignment. Fellows will receive regular feedback and guidance from their mentor(s) and participate in a formal annual review process to review project progress and individual performance and provide career coaching.
Responsibilities
  • Lead Independent Research: Focus on their own project(s), which should pursue new research directions with dedicated resources for innovative and potentially high-risk/high-reward research
  • Contribute to Calico's Core Mission: Contribute to furthering an understanding of aging and age-related diseases
  • Drive Scientific Progress: Execute experiments meticulously, analyze data (including computational analysis if applicable) and troubleshoot procedures as needed
  • Publish Work: Generate work that is expected to be submitted for publication in a timely fashion upon completion of the assignment
  • Collaborate and Communicate: Actively collaborate across Calico's diverse teams and scientific community, including presenting progress and results to diverse audiences of computational scientists, lab scientists, and engineers
  • Professional Development: Engage with a community of other Postdoctoral Fellows and senior leadership through professional and career development opportunities, such as the annual Postdoc Summit, research-in-progress presentations, senior leader lunch sessions, and skill-building workshops

Position Requirements
The successful candidate will demonstrate characteristics valued across Calico's programs, including being a self-motivated team player, detail-oriented, extremely organized, and comfortable working on complex problems.
  • Education: Must have recently completed a PhD degree in a relevant scientific or computational field
    • Current PhD student applicants should be within 12 months of completing their PhD
    • Applicants who have already graduated must have completed their PhD within the past 3 years and not have been employed as a postdoc at more than one other lab/company since graduation
  • Experience: Must have made important contributions to science in their area, ideally demonstrated by having had a meaningful first author paper accepted for publication
  • Technical Versatility (General): While specific technical skills are project-dependent, proficiency in core scientific methodologies, analytical skills, and quantitative problem-solving is essential
  • Communication: Strong teamwork and communication skills are required
  • Adaptability: Must be flexible and able to respond quickly to shifting priorities, demonstrating a "can-do" attitude
  • Onsite Availability: Must be willing to work onsite five days per week

Application Requirements
The Postdoctoral Fellowship has four application components:
  • Research proposal (a 1-2 page creative and original research proposal on what you'd like to investigate in the Hahn Lab during your fellowship - note that project goals may evolve during the training period)
  • Updated CV with a full list of publications
  • Cover letter
  • List of 2-3 references that we may contact, including your PhD thesis advisor and any postdoctoral advisors (if applicable)

The estimated base salary for this role is $95,000. More information on our postdoctoral fellowship program can be found here.
About the Hahn Lab
We investigate why specific cells in the brain, such as the resident immune cells, microglia, are among the earliest and most vulnerable sites of aging, and how this vulnerability contributes to neurodegeneration. Our central mission is to decode and ultimately reprogram the brain's immune system to dampen or reverse age-related neuroinflammation.
The group has established a rich arsenal of novel in vitro and in vivo discovery platforms. These include scalable heterochronic myeloid cell replacement paradigms that swap native microglia with CRISPR-ready donor cells across young and old brains, and a new protocol for generating neuroimmune cells in vitro at a very large scale. These novel approaches are complemented by world-class CNS research equipment including custom FACS instruments, bespoke electrophysiology setups and 2 Photon in vivo imaging suites. We welcome proposals that aim to decode altered cell-cell signaling in the CNS through scalable in vitro or ex vivo experimentation. The ideal candidate is a highly motivated innovator with a strong collaborative streak and a drive to take discoveries from cellular models to whole organisms.
Publications from the group include:
  • Full Google Scholar
  • Gizowski & Popova et al., Heterochronic myeloid cell replacement reveals the local brain environment as key driver of microglia aging (2025) BioRxiv
  • Hahn et al., Atlas of the aging mouse brain reveals white matter as vulnerable foci (2023) Cell
  • Schaum & Lehallier & Hahn et al., Ageing hallmarks exhibit organ-specific temporal signatures (2020) Nature

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