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Duke University

POSTDOCTORAL ASSOCIATE

Durham, NC · On-site

Composed of more than 2,600 faculty physicians and researchers, nearly 2,000 students, and more ... and even microglia. Building on this work, we seek to harness the power of this new tool to ...

Duke University

POSTDOCTORAL ASSOCIATE

Durham, NC

Composed of more than 2,600 faculty physicians and researchers, nearly 2,000 students, and more ... and even microglia. Building on this work, we seek to harness the power of this new tool to ...

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What are some typical challenges faced when conducting microglia research in a laboratory setting?

One common challenge in microglia research is maintaining the viability and purity of microglial cultures, as these cells are highly sensitive and can be easily activated by external stimuli. Researchers often need to troubleshoot protocols frequently and adjust to variability in cell responses. Additionally, distinguishing microglia from other glial cells in mixed cultures or tissue samples can require advanced techniques such as flow cytometry or immunostaining. Collaboration with neuroscientists, immunologists, and bioinformaticians is also essential to interpret complex data and advance projects efficiently.

What is microglia research?

Microglia research is the scientific study of microglia, which are specialized immune cells found in the central nervous system. Researchers in this field investigate how microglia function in both healthy and diseased brains, including their roles in neuroinflammation, brain development, and neurodegenerative diseases like Alzheimer's. The aim is to better understand how microglia contribute to brain health and to identify potential therapeutic targets for neurological conditions.

What are the key skills and qualifications needed to thrive in Microglia Research, and why are they important?

To thrive in Microglia Research, you need a strong background in neuroscience, cellular/molecular biology, and experimental design, typically with a PhD or relevant advanced degree. Familiarity with technical tools such as immunohistochemistry, flow cytometry, imaging techniques (e.g., confocal microscopy), and data analysis software (e.g., ImageJ, GraphPad Prism) is crucial. Strong analytical thinking, attention to detail, and collaborative communication skills are essential soft skills in this role. These competencies ensure rigorous experimental work, insightful data interpretation, and effective teamwork in advancing understanding of microglial function and pathology.
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Infographic showing various Microglia Research job openings in the United States as of May 2026, with employment types broken down into 7% As Needed, 86% Part Time, and 7% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution.

Senior Research Associate/Associate Scientist, Cell Process Development & Manufacturing

Retro

Redwood City, CA

$115K - $140K/yr

Full-time

Medical, Dental, Vision, Retirement

Posted 25 days ago

Job description

Retro develops therapies for diseases driven by the biology of aging. We focus on cellular reprogramming and autophagy to broadly improve tissue function by targeting mechanisms of aging with the ultimate aim of adding 10 years to healthy human lifespan.

We're building a mission-driven team of accomplished and kind individuals who embrace our startup culture of rapid iteration, transparency, and versatility.

We are hiring a new member of the Microglia Therapeutics team* who will help us ramp toward manufacturing readiness. In the near term, this role will focus on hands-on execution of cell culture and manufacturing-related activities in support of GMP readiness and production. Over time, as manufacturing operations become established, this person may also contribute more broadly to process development activities. 

About you:

You are a thoughtful, hands-on team member who likes making complicated things work in the real world. You bring strong experience with iPSC-derived cell types and understand the care, consistency, and discipline required to work with live cell products. You move fast, sweat the details, and do not see speed and rigor as opposites. You are comfortable with repetitive, SOP-driven work and take pride in doing it with consistency and care, while also staying curious, noticing when something is off, and looking for ways to help the team and process work better. You are organized, collaborative, and low-ego, and you are willing to jump in where needed to help the team succeed. You communicate clearly, take ownership of your work, and are excited to help move the mission forward.

In this role you will:

  • Perform culture of mammalian cells, mainly iPSCs using aseptic technique.

  • Differentiate iPSCs to brain cell types like microglia in a bioreactor.

  • Formulate media and reagents for PD and manufacturing activities. 

  • Follow SOPs and perform work in a GMP facility. 

  • Work collaboratively across Retro teams such as Manufacturing, Assay Development, Quality Control, Automation, etc.

  • Analyze and present experimental data to our internal teams and collaborators.

  • Maintain highly organized and detailed notes in an electronic lab notebook and contribute to supporting documents.

  • Perform regular lab organization activities and ordering.

You might thrive in this role if you:

  • Have a B.S. in Biology or a related field and at least 5 years of relevant experience, or an M.S. with at least 3 years of post-degree research experience.

  • Have hands-on experience with mammalian cell culture, including work with bioreactors and process development activities.

  • Are willing to do hands-on manufacturing work and can execute consistently in structured, SOP-driven environments.

  • Work well in a collaborative, fast-moving environment and maintain detailed, high-quality documentation.

It's a bonus if you:

  • Have experience with iPSCs or microglia culture.

  • Have worked in a GMP manufacturing facility.

$115,000 - $140,000 a year

*At Retro, we don't use titles. New hires join as a "Member of X Team". The expectations for this role are generally aligned to levels ranging from Senior RA or Associate Scientist. 

Total compensation also includes generous equity and benefits including:

- Medical, dental, and vision insurance for you and your family

- 401(k) plan with 4% matching

- Flexible time off and 10 company holidays per year

- Paid parental leave

- Annual learning & development stipend

- Monthly Longevity stipend

- Daily Retro-sponsored lunch and snacks

We take pride in cultivating an environment that fosters collaboration, open communication, and authenticity. We believe that great results are best delivered by a highly creative team working in concert. We are an equal opportunity employer; we do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. We are diverse in background and singular in mission.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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