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Method Development Jobs in Massachusetts (NOW HIRING)

ICONMA

Sr. Development Quality Engineer

Westford, MA · On-site

$92K - $124K/yr

... method development and lead test method validation activities • Support manufacturing process development & qualification for new product and design changes • Support the establishment of ...

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All JobsMethod Development JobsMethod Development Jobs in Massachusetts

Method Development information

See Massachusetts salary details

$31.7K

$58.3K

$88.5K

How much do method development jobs pay per year?

As of Jun 19, 2026, the average yearly pay for method development in Massachusetts is $58,339.00, according to ZipRecruiter salary data. Most workers in this role earn between $46,400.00 and $65,500.00 per year, depending on experience, location, and employer.

What are some common challenges encountered in a Method Development role, and how are they typically addressed?

Professionals in Method Development often face challenges such as optimizing analytical techniques for complex samples, ensuring methods are robust and reproducible, and meeting stringent regulatory requirements. Addressing these challenges involves a systematic approach, including thorough literature review, iterative experimentation, and close collaboration with cross-functional teams (such as Quality Assurance and R&D) to validate and troubleshoot methods. Staying updated on industry best practices and regulatory guidelines is also crucial for success in this role.

What is the difference between Method Development vs Analytical Chemist?

AspectMethod DevelopmentAnalytical Chemist
Primary FocusDesigning and optimizing new analytical methodsPerforming analysis using established methods
Work EnvironmentResearch labs, R&D departmentsQuality control labs, manufacturing facilities
Required CredentialsBachelor's or higher in Chemistry or related field; experience in method developmentBachelor's or higher in Chemistry; experience in analytical techniques

Method Development specialists focus on creating and refining new analytical procedures, while Analytical Chemists primarily perform routine analysis using existing methods. Both roles require strong chemistry knowledge, but Method Development involves more innovation and method optimization, often in research settings, whereas Analytical Chemists focus on quality control and routine testing in production environments.

What are the key skills and qualifications needed to thrive in Method Development, and why are they important?

To excel in Method Development, you need a strong background in analytical chemistry, laboratory techniques, and scientific problem-solving, often supported by a degree in chemistry or a related field. Familiarity with analytical instruments such as HPLC, GC, and mass spectrometry, as well as knowledge of relevant regulatory guidelines and software for data analysis, is typically required. Attention to detail, critical thinking, and effective communication are crucial soft skills for designing robust methods and collaborating with cross-functional teams. These capabilities ensure the development of accurate, reliable methods that support research, quality control, and regulatory compliance.

What is method development in a laboratory setting?

Method development refers to the process of creating, optimizing, and validating analytical procedures or techniques used to identify, quantify, and analyze substances in various samples. This is crucial in industries like pharmaceuticals, environmental testing, and food safety to ensure accurate and reliable results. The process involves selecting appropriate instruments, developing sample preparation steps, and validating the method to meet regulatory and quality standards. Skilled professionals in method development help ensure that tests are robust, reproducible, and suitable for their intended purposes.
What are popular job titles related to Method Development jobs in Massachusetts? For Method Development jobs in Massachusetts, the most frequently searched job titles are:
What job categories do people searching Method Development jobs in Massachusetts look for? The top searched job categories for Method Development jobs in Massachusetts are:
Method Development jobs near you
Infographic showing various Method Development job openings in Massachusetts as of June 2026, with employment types broken down into 97% Full Time, 1% Part Time, and 2% Contract. Highlights an 94% Physical, 1% Hybrid, and 5% Remote job distribution, with an average salary of $58,339 per year, or $28 per hour.
Director, Analytical Development

Director, Analytical Development

Sarepta Therapeutics, Inc.

Bedford, MA • On-site

$185K - $232K/yr

Full-time

Posted 18 days ago

Job description

Why Sarepta? Why Now?
The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.
We're looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta Offers
At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
  • Physical and Emotional Wellness
  • Financial Wellness
  • Support for Caregivers

For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
The Importance of the Role
The Director of Analytical Development will spearhead the advancement of analytical methods and control strategies critical to our siRNA and antisense oligonucleotides portfolio. The role will represent Analytical Development on CMC teams and provide leadership that will be crucial from R&D transition to commercialization, ensuring robust support throughout the product lifecycle. The individual will have demonstratable expertise in managing analytical activities at external drug substance and drug product manufacturing sites, and providing chemistry expertise for RNA therapeutics. In addition, the individual will offer comprehensive experience in product characterization and comparability assessments. Additionally, the Director will lead the writing and compilation of regulatory documents to support product development and registration.
The Opportunity to Make a Difference
  • Provide leadership and mentorship to a team of scientists and analysts
  • Characterize new products to support regulatory submissions and lifecycle comparability.
  • Ensure process for documenting and transferring analytical methods to Quality Control and external facilities are in place.
  • Drive innovation in analytical method development for oligonucleotide therapeutics
  • Collaborate with cross-functional teams including process development, MS&T, QC, QA and regulatory affairs.
  • Manage relationships with CDMOs, CTLs, and other external partners.
  • Oversee critical sections of IND and NDA submissions and respond to health authority inquiries.

More about You
  • PhD in Chemistry, Chemical Engineering, Pharmaceutical Engineering, or a related field preferred.
  • Minimum of 7 years of experience in pharmaceutical/biopharmaceutical analytical development.
  • Minimum of 5 years of experience in a managerial capacity.
  • Extensive expertise in analytical method development and control strategy for RNA-based therapeutics.
  • In-depth knowledge of analytical techniques and regulatory requirements.
  • Strong analytical and problem-solving abilities.
  • Proven track record in preparing Module 3 sections for regulatory submissions.
  • Demonstrated ability in leading cross-functional teams and projects.
  • Strong collaboration and teamwork skills, with the ability to support cross-functional peers and maintain a safe, efficient, and compliant laboratory environment.
  • Capability to foster innovation and integrate new technologies into analytical development practices.
  • Experience working with contract laboratories and external vendors (CROs/CMOs) is highly desirable.

What Now?
We're always looking for solution-oriented, critical thinkers.
So, if you're comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
#LI-Hybrid
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This position is hybrid, you will be expected to work on site at one of Sarepta's facilities in the United States and/or attend Company-sponsored in-person events from time to time.
The targeted salary range for this position is $185,600 - $232,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta's compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.
Candidates must be authorized to work in the U.S.
Sarepta Therapeutics offers a competitive compensation and benefit package.
Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.

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