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Method Development Jobs in Massachusetts (NOW HIRING)

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R&D Mechanical Engineer

Marlborough, MA · On-site

$65 - $70/hr

Design Verification test method development and validation * Essential Design Output identification; System/Subsystem/Component requirements tracing; and Design FMEA * Providing input to project ...

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Amgen

Process Development Senior Scientist

Cambridge, MA · On-site

$100K - $136K/yr

Define analytical control strategies and implement methodologies to support the development of late-phase clinical programs, with a strong ability to articulate the challenges and complexities ...

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All JobsMethod Development JobsMethod Development Jobs in Massachusetts

Method Development information

See Massachusetts salary details

$31.7K

$58.3K

$88.5K

How much do method development jobs pay per year?

As of Sep 10, 2026, the average yearly pay for method development in Massachusetts is $58,339.00, according to ZipRecruiter salary data. Most workers in this role earn between $46,400.00 and $65,500.00 per year, depending on experience, location, and employer.

What is method development?

Method development refers to the process of creating, optimizing, and validating analytical procedures or techniques used to identify, quantify, and analyze substances in various samples. This is crucial in industries like pharmaceuticals, environmental testing, and food safety to ensure accurate and reliable results. The process involves selecting appropriate instruments, developing sample preparation steps, and validating the method to meet regulatory and quality standards. Skilled professionals in method development help ensure that tests are robust, reproducible, and suitable for their intended purposes.

What are the key skills and qualifications needed to thrive in method development?

To excel in Method Development, you need a strong background in analytical chemistry, laboratory techniques, and scientific problem-solving, often supported by a degree in chemistry or a related field. Familiarity with analytical instruments such as HPLC, GC, and mass spectrometry, as well as knowledge of relevant regulatory guidelines and software for data analysis, is typically required. Attention to detail, critical thinking, and effective communication are crucial soft skills for designing robust methods and collaborating with cross-functional teams. These capabilities ensure the development of accurate, reliable methods that support research, quality control, and regulatory compliance.

What are some common challenges encountered in a method development role, and how are they typically addressed?

Professionals in Method Development often face challenges such as optimizing analytical techniques for complex samples, ensuring methods are robust and reproducible, and meeting stringent regulatory requirements. Addressing these challenges involves a systematic approach, including thorough literature review, iterative experimentation, and close collaboration with cross-functional teams (such as Quality Assurance and R&D) to validate and troubleshoot methods. Staying updated on industry best practices and regulatory guidelines is also crucial for success in this role.

What is the difference between Method Development vs Analytical Chemist?

AspectMethod DevelopmentAnalytical Chemist
Primary FocusDesigning and optimizing new analytical methodsPerforming analysis using established methods
Work EnvironmentResearch labs, R&D departmentsQuality control labs, manufacturing facilities
Required CredentialsBachelor's or higher in Chemistry or related field; experience in method developmentBachelor's or higher in Chemistry; experience in analytical techniques

Method Development specialists focus on creating and refining new analytical procedures, while Analytical Chemists primarily perform routine analysis using existing methods. Both roles require strong chemistry knowledge, but Method Development involves more innovation and method optimization, often in research settings, whereas Analytical Chemists focus on quality control and routine testing in production environments.

What are popular job titles related to Method Development jobs in Massachusetts?

For Method Development jobs in Massachusetts, the most frequently searched job titles are:

What job categories do people searching Method Development jobs in Massachusetts look for?

The top searched job categories for Method Development jobs in Massachusetts are:

Method Development jobs near you
Infographic showing various Method Development job openings in Massachusetts as of August 2026, with employment types broken down into 1% As Needed, 86% Full Time, 11% Part Time, and 2% Contract. Highlights an 89% Physical, 3% Hybrid, and 8% Remote job distribution, with an average salary of $58,339 per year, or $28 per hour.

Senior / Principal Scientist Analytical Method Development Lead

Woburn, MA • On-site

Terrestrial Bio, Inc.
See more jobs at Terrestrial Bio, Inc.external

$125K - $180K/yr

Other

Posted 2 days ago

New

Job description

Terrestrial Bio

Location: Allston, MA and Woburn, MA

About Terrestrial Bio, Inc.

Terrestrial is transforming the delivery of next-generation therapies, starting with GLP-1.

Terrestrial's proprietary Tacterraâ„¢ microarray patch (MAP) and applicator platform consists of a patch resembling an adhesive bandage, which is applied with a preloaded applicator and removed after a few minutes. Once applied, each patch delivers bioactive tips into the skin, which dissolve quickly into the body, rapidly releasing their therapeutic payload. Designed for self-administration, the temperature-stable Tacterraâ„¢ platform enables precise, controlled delivery of a wide range of therapeutics without medical sharps or refrigeration.

Terrestrial has generated strong clinical and in-vivo proof of concept across multiple molecules. For more information, visit www.terrestrialbio.com.

Why this role

We are seeking an Analytical Method Development (AMD) Lead to drive the analytical method development, qualification, and validation strategy for the microneedle array patch (MAP) program. This individual will lead the development of release and characterization methods including HPLC/UPLC, LC-MS, and functional assays and own the analytical method lifecycle from Phase 2 through Phase 3 IND and commercialization.

This is a senior technical leadership role for a scientist with deep peptide/biologic analytical expertise and a track record of building robust, regulatory-compliant methods.

What you'll do

  • Lead analytical method development for release and characterization assays including RP-HPLC/UPLC purity, content, SEC, and impurity characterization by LC-MS.

  • Define and execute the analytical method validation strategy per ICH Q2(R2) and Q14.

  • Develop the Validation Master Plan (VMP) governing method qualification, validation, transfer, and lifecycle management.

  • Establish the impurity characterization strategy for GLP-1 peptide, including oxidation, deamidation, and related substances.

  • Lead method transfers to QC and to/from external CROs.

  • Define the analytical control strategy and specifications for Phase 2 Tox and Phase 3 clinical lots.

  • Support characterization of reference standards and establishment of bridging strategies.

  • Author analytical sections of regulatory submissions (IND, CMC) and serve as analytical SME during inspections.

  • Guide the development of the potency/functional assay strategy in collaboration with pre-clinical and formulation teams.

  • Mentor and develop method development scientists; provide technical leadership across the AMD function.

Who you are

  • Ph.D. in Analytical Chemistry, Biochemistry, or related field with 6+ years relevant experience, OR M.S. with 8+ years in pharmaceutical/biotech analytical method development.

  • Deep expertise in HPLC/UPLC method development for peptides or biologics.

  • Hands-on experience with LC-MS for impurity characterization and structural analysis.

  • Demonstrated experience leading method validation under ICH Q2(R2)/Q14.

  • Experience developing analytical control strategies and specifications for clinical-stage products.

  • Strong knowledge of ICH Q6A, Q3A/B/C/D, and FDA/EMA CMC expectations.

Preferred Qualifications

  • Experience with GLP-1 peptides or semaglutide analytical methods.

  • Experience with microneedle/transdermal or drug-device combination products.

  • Prior experience defining potency or cell-based functional assay strategies.

  • Experience supporting IND/BLA filings and regulatory interactions.

  • Experience building and scaling an analytical method development function.

Key Competencies

  • Deep technical expertise combined with strategic program thinking.

  • Strong leadership and mentoring capability.

  • Excellent scientific writing and regulatory communication.

  • Ability to balance scientific rigor with program timelines in a fast-paced environment.

Compensation:

The anticipated base salary range for this position is $125,000 - $180,000. Actual compensation will be determined based on a variety of factors including experience, qualifications, and internal equity.

Onsite expectations:

The majority of our roles at Terrestrial are either onsite or hybrid, which allows us to meet both business and team needs. Candidates applying must be willing to be onsite 4-5 days per week.

Location:

Woburn, MA and our new, custom facility in Allston MA planned for Q4 of 2026.

At Terrestrial, we’re bringing together exceptional talent to drive our product development forward. We value collaboration, curiosity, and a dynamic work environment. We aim to recruit, employ, train, compensate and promote regardless of race, religion, color, national origin, sex, gender identity or expression, sexual orientation, disability, age, or veteran status.

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