Metabolomics Jobs (NOW HIRING)

Job Description
The Integrated Data Science Laboratory for Metabolomics and Exposomics (IDSL-ME) is seeking a highly skilled Senior Scientist to manage and lead high-impact research initiatives in metabolomics and exposomics. The IDSL-ME laboratory is at the forefront of biomedical research, focusing on the development of next-generation knowledgebases and computational approaches to study environmental exposures (exposomics) and their impact on human health.
In this pivotal role, the Senior Scientist will lead the granular analysis of complex metabolomics and exposomics datasets derived from large-scale patient cohorts, with a specific research focus on Cancer, Neurodevelopment, and Alzheimer's disease. The position requires deep expertise in metabolic network analysis, employing reaction-based and pathway-based algorithms to interpret multi-omics data. The Senior Scientist will act as a strategic technical lead, architecting analytical frameworks that bridge internal research at Mount Sinai with data from external consortia across the USA and abroad. The Senior Scientist will also play a key role in securing extramural funding, mentoring junior staff, and disseminating findings through peer-reviewed publications.
Responsibilities
Large-Scale Exposomics & Metabolomics in Disease Cohorts (25%): The Senior Scientist will lead the computational analysis of high-dimensional metabolomics and exposomics data from large-scale human cohorts. This involves designing and implementing statistical and machine learning workflows to identify environmental and metabolic biomarkers associated with Cancer, Neurodevelopmental disorders, and Alzheimer's disease. The Scientist will be responsible for processing raw mass spectrometry data and translating it into biological insights that elucidate the mechanisms of disease progression in these specific pathologies.
Metabolic Network Analysis & Multi-Omics Integration (20%) The Senior Scientist will perform advanced Metabolic Network Analysis, utilizing reactions, metabolic pathways, and gene-protein-reaction associations to model cellular metabolism. This includes 1) Developing and deploying pipelines for the integration of multi-omics data (transcriptomics, proteomics, and metabolomics). 2) Mapping experimental data onto genome-scale metabolic networks to simulate flux and pathway activity. 3) Identifying dysregulated metabolic reactions that are dysregulated and environmental exposures and may also serve as potential therapeutic targets for immune and neurodegenerative conditions.
Strategic Collaboration & External Partnerships (15%) The Senior Scientist will serve as a primary liaison for collaborative research initiatives. This includes facilitating data sharing and joint analysis with internal departments at the Icahn School of Medicine at Mount Sinai and external research organizations and consortia within the USA and abroad. The Scientist will harmonize disparate datasets across institutions to ensure interoperability and robust statistical power for large cohort studies.
Implementation of AI-Agents & Large Language Models (15%) Leveraging state-of-the-art Artificial Intelligence, the Senior Scientist will oversee the development of AI-Agents using Large Language Models to accelerate literature mining and hypothesis generation. These agents will be deployed to extract structured information (chemical structures, reaction pathways, disease associations) from scientific literature, supporting the lab's focus on drug repurposing and mechanism discovery.
Mass Spectrometry Informatics & Knowledge Graph Construction (15%) The Senior Scientist will manage the architecture of scientific databases that house critical metabolomics and exposomics datasets. Responsibilities include designing schemas for structured and non-structured databases and applying chemometric principles to annotate unknown compounds. The Scientist will utilize spectral similarity algorithms to enhance the identification of metabolites in complex biological matrices.
Leadership, Mentorship, and Funding (10%) The Senior Scientist will take a lead role in securing research funding by conceptualizing and writing grant proposals (e.g., NIH, NSF). The Scientist will provide technical mentorship to postdoctoral fellows and graduate students, ensuring best practices in software engineering and data stewardship (FAIR principles). Additionally, the Scientist will serve as a lead author on peer-reviewed manuscripts.
Qualifications

• Ph.D in sciences or related field
• Minimum five years of experience with scientific investigation.
• Must have demonstrated outstanding achievement in a field of research
• Must have contributed to a number of peer-reviewed publications, inventions or the like, at least some of which have had a major impact on advancing the field or discipline.
• Prior experience successfully securing external grant funding is highly desirable.

Preferred Skills

• Education: Ph.D. in Biotechnology, Computational Biology, Systems Biology, Bioinformatics, or a closely related technical field.
• Experience: A minimum of five (5) to six (6) years of postdoctoral or specialized research experience following the completion of the Ph.D..
• Technical Expertise: Proven expertise in modeling metabolic networks using reactions, pathways, and constraint-based modeling techniques and metabolic network analysis using Cytoscape. Demonstrated experience developing pipelines to integrate metabolomics with transcriptomics or proteomics data.
• Disease-specific application: Experience applying systems biology approaches to complex diseases such as Cancer, Immune disorders, or infectious diseases, with transferable skills to Neurodevelopment/Alzheimer's.
• Programming: Proficiency in Python and R for large-scale data analysis and visualization.
• Publication Record: Strong record of first or corresponding author publications in peer-reviewed journals.

, 822 - Environmental Medicine - ISM, Icahn School of Medicine
Compensation Statement
The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $58,661.00 - $125,008.22 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.
About Us
Strength through Unity and Inclusion
The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai's unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.
At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.
About the Mount Sinai Health System:
Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients' medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's "Best Children's Hospitals" ranks Mount Sinai Kravis Children's Hospital among the country's best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's "The World's Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.
Equal Opportunity Employer
The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.