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Manager Principal Scientist Jobs (NOW HIRING)

MSD Malaysia

Principal Scientist/Director, Biologics Drug Substance Commercialization Join Our Company ... Preferred qualifications include people management skills, hands-on experience with advanced ...

Merck & Co.

Principal Scientist/Director, Biologics Drug Substance CommercializationJoin Our Company ... Preferred qualifications include people management skills, hands-on experience with advanced ...

Tribonet

Sr. Principal Scientist

Denver, CO · On-site

The Sr. Principal Scientist translates scientific insights into commercial value through strategic ... in the knowledge management system, and ensure adherence to all safety and quality standards

Tribonet

The Sr. Principal Scientist translates scientific insights into commercial value through strategic ... in the knowledge management system, and ensure adherence to all safety and quality standards

Ardent Mills

Sr. Principal Scientist

Denver, CO · On-site

Join Us Today The Sr. Principal Scientist serves as a scientific leader and recognized subject ... in the knowledge management system, and ensure adherence to all safety and quality standards

Ardent Mills

Sr. Principal Scientist

Denver, CO · On-site

The Sr. Principal Scientist serves as a scientific leader and recognized subject matter expert in ... in the knowledge management system, and ensure adherence to all safety and quality standards

Ardent Mills

Sr. Principal Scientist

Denver, CO · On-site

The Sr. Principal Scientist serves as a scientific leader and recognized subject matter expert in ... in the knowledge management system, and ensure adherence to all safety and quality standards

Keurig Dr Pepper

Principal Scientist

Frisco, TX · On-site

$96K - $133K/yr

The R&D Principal Scientist, Analytical Chemistry serves as the organization's senior technical ... Manage, coach, mentor, and develop laboratory technicians and junior scientists through clear work ...

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Manager Principal Scientist information

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How much do manager principal scientist jobs pay per year?

As of Sep 14, 2026, the average yearly pay for manager principal scientist in the United States is $144,009.00, according to ZipRecruiter salary data. Most workers in this role earn between $117,500.00 and $169,000.00 per year, depending on experience, location, and employer.

What is a manager principal scientist?

Manager Principal Scientists are experienced researchers who lead scientific teams and projects, often within industries like pharmaceuticals, biotechnology, or environmental science. They combine deep scientific expertise with leadership responsibilities, overseeing research activities, mentoring staff, and ensuring project goals align with organizational strategy. In addition to conducting high-level research, they manage budgets, collaborate across departments, and contribute to setting the scientific direction of their organization.

What are the key skills and qualifications needed to thrive as a manager principal scientist?

To thrive as a Manager Principal Scientist, you need advanced scientific expertise, typically a PhD in a relevant field, and substantial experience in research and project leadership. Proficiency with specialized laboratory equipment, data analysis software, and familiarity with regulatory compliance systems are commonly required. Outstanding leadership, mentoring abilities, and cross-functional communication skills help distinguish top performers in this role. These competencies are crucial for driving innovative research, ensuring project success, and effectively leading scientific teams.

How does a manager principal scientist typically balance leadership responsibilities with hands-on scientific research?

A Manager Principal Scientist is often expected to split their time between leading a team and contributing directly to research projects. This means overseeing the scientific direction, mentoring junior scientists, and ensuring project milestones are met, while also designing experiments and analyzing data themselves. Balancing these responsibilities can be challenging, but strong organizational skills and effective delegation are crucial. Collaborating with other departments, such as regulatory, clinical, or product development teams, is also a key part of the role, ensuring scientific objectives align with broader organizational goals.

What is the difference between Manager Principal Scientist vs Principal Scientist?

AspectManager Principal ScientistPrincipal Scientist
CredentialsAdvanced degrees (PhD), leadership experience, often managerial certificationsAdvanced degrees (PhD), deep technical expertise, research-focused
Work EnvironmentLeads teams, manages projects, strategic planningConducts independent research, develops scientific innovations
Employer & Industry UsageCommon in biotech, pharma, and R&D firms with team managementFound in similar industries, focusing on technical expertise

The main difference is that a Manager Principal Scientist combines scientific expertise with team leadership and project management, whereas a Principal Scientist primarily focuses on advanced research and technical contributions without managerial duties.

What cities are hiring for Manager Principal Scientist jobs?

Cities with the most Manager Principal Scientist job openings:

What are the most commonly searched types of Principal Scientist jobs?

The most popular types of Principal Scientist jobs are:

What states have the most Manager Principal Scientist jobs?

States with the most job openings for Manager Principal Scientist jobs include:

What are popular job titles related to Manager Principal Scientist jobs?

For Manager Principal Scientist jobs, the most frequently searched job titles are:

Manager Principal Scientist jobs near you

Principal Scientist, Toxicology

Bridgewater, NJ • On-site

Ptc Therapeutics, Inc.
Manufacturing • 501 - 1,000 employees
Learn more about Ptc Therapeutics, Inc.external

$165K - $185K/yr

Full-time

Medical, Dental, Vision, Retirement

Re-posted 5 days ago

Key responsibilities

  • Designs and oversees nonclinical safety studies to support the development program for candidate compounds.

  • Develops protocols, monitors studies, and reviews, revises, and issues reports required for the nonclinical program.

  • Prepares regulatory documents including Toxicology sections of briefing books, INDs, and investigator brochures.

Job description

PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life's moments for children and adults living with a rare disease.

At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging.

Visit our website to learn more about our company and culture!
Site: www.ptcbio.com

Job Description Summary: The Principal Scientist, Toxicology is responsible for the design and oversight of nonclinical safety studies of development candidates. The Principal Scientist works independently to plan, execute and interpret nonclinical safety studies. He/she will interact within the organization to communicate relevant safety information and act as a toxicology representative in interactions with Project teams, Collaborators, and Contract Research Organizations (CROs).
The incumbent works cross-functionally with internal departments and external resources on nonclinical safety-related issues.
The Principal Scientist, Toxicology has a thorough knowledge of and ensures adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate.Job Description:

ESSENTIAL FUNCTIONS

Primary duties/responsibilities:

  • Designs and oversees studies in support of the nonclinical development program for development candidate compounds.
  • Develops protocols and monitors studies, as well as reviews, revises, and issues reports required for the nonclinical program.
  • Writes/Prepares regulatory documents including Toxicology sections of briefing books, investigational new drug applications (INDs), and investigator brochures (IBs).
  • Acts as a toxicology representative in interactions with collaborators and contract research organizations.
  • Performs other tasks and assignments as needed and specified by management.

KNOWLEDGE/SKILLS/ABILITIES REQUIRED

Minimum level of education and years of relevant work experience:

  • Ph.D. in Toxicology or other related discipline and a minimum of 7 years experience with progressively increasing responsibilities in a pharmaceutical, biotechnology or related environment.

Special knowledge or skills needed and/or licenses or certificates required:

  • Hands on experience with nonclinical safety studies.
  • Experience in the conduct of studies in compliance with Good Laboratory Practices (GLP).
  • Demonstrated and applied knowledge of US and international regulatory requirements for the conduct and design of nonclinical safety studies.
  • Demonstrated ability to write scientific documents and reports. These include, but may not be limited to, protocols, reports, and regulatory documents/submissions.
  • Proficiency with Microsoft Office.
  • Excellent verbal and written communication skills.
  • Ability to work independently and collaboratively, as required, in a fast-paced, matrixed, team environment consisting of internal and external team members.
  • Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.
  • Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects.

Special knowledge or skills and/or licenses or certificates preferred:

  • Diplomate of the American Board of Toxicology (DABT)
  • Experience with orphan diseases.

Travel requirements:

  • 10-25%

Expected Base Salary Range

$165,000 - $185,000. The base salary offered will be contingent on assessment of candidate education level, background, and experience relative to the requirements of the position they are being considered for, as well as review of internal equity.

In addition to base salary, PTC employees are also eligible for short- and long-term incentives.All eligible employees may also enroll in PTC's medical, dental, vision, and retirement savings plans.

EEO Statement:

PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.

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