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Internship Downstream Process Development Scientist Jobs

Legend Biotech USA, Inc.

Role OverviewThe Principal Engineer, Lentivirus Downstream Process Development, will be a key ... The successful candidate will drive scientific excellence in scaling automation capabilities from ...

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How much do internship downstream process development scientist jobs pay per hour?

As of Sep 10, 2026, the average hourly pay for internship downstream process development scientist in the United States is $38.66, according to ZipRecruiter salary data. Most workers in this role earn between $28.37 and $46.15 per hour, depending on experience, location, and employer.

What does an internship downstream process development scientist do?

An Internship Downstream Process Development Scientist works in the biopharmaceutical industry, assisting with the development and optimization of processes that purify biological products such as proteins, antibodies, or vaccines after they are produced by cells. Their role often involves supporting laboratory experiments, analyzing samples, and documenting results to improve the efficiency and scalability of downstream processes like filtration and chromatography. Interns in this position gain hands-on experience with cutting-edge technologies and learn about regulatory requirements and industry standards. This role helps prepare students or recent graduates for a career in process development or biomanufacturing.

What types of projects and responsibilities can an internship downstream process development scientist expect to work on?

As an Internship Downstream Process Development Scientist, you can expect to be involved in hands-on laboratory work focusing on the purification and characterization of biopharmaceutical products. Typical responsibilities include preparing buffer solutions, operating chromatography and filtration systems, analyzing samples using various analytical techniques, and documenting experimental results. Interns often collaborate with experienced scientists and engineers, contributing to process optimization and troubleshooting. The role provides valuable exposure to industry-standard procedures and the opportunity to develop technical skills in a team-oriented environment.

What are the key skills and qualifications needed to thrive as an internship downstream process development scientist, and why are they important?

To thrive as an Internship Downstream Process Development Scientist, you need foundational knowledge in biochemistry, molecular biology, or chemical engineering, often supported by ongoing or recent enrollment in a relevant degree program. Familiarity with laboratory techniques such as chromatography, filtration, and analytical instruments, as well as experience with lab management software, is typically expected. Attention to detail, problem-solving abilities, and effective teamwork are standout soft skills in this role. These skills and qualifications are crucial for conducting reliable experiments, analyzing data, and contributing to the optimization of bioprocesses in a collaborative research environment.
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Internship Downstream Process Development Scientist jobs near you
Infographic showing various Internship Downstream Process Development Scientist job openings in the United States as of September 2026, with employment types broken down into 1% Internship, 1% As Needed, 82% Full Time, 14% Part Time, and 2% Contract. Highlights an 87% Physical, 2% Hybrid, and 11% Remote job distribution, with an average salary of $80,420 per year, or $38.7 per hour.

Principal Engineer, Lentivirus Downstream Process Development

Somerset, NJ • On-site

Legend Biotech US
See more jobs at Legend Biotech USexternal

Full-time

Re-posted 11 days ago

Key responsibilities

  • Design, optimize, and scale purification processes for lentiviral vectors including clarification, chromatography, and TFF.

  • Build and apply mechanistic, hybrid, and in silico process models using engineering principles and data analytics to improve downstream processing.

  • Lead the translation of bench-scale processes to GMP manufacturing, ensuring seamless technology transfer and troubleshooting during clinical production.

Job description

Legend Biotech is seeking a Principal Engineer, Lentivirus Downstream Process Development as part of the Technical Development team based in Somerset, NJ.

Role Overview

The Principal Engineer, Lentivirus Downstream Process Development, will be a key technical leader responsible for designing, optimizing, and scaling purification processes for lentiviral vectors (LVV) within our
innovative pipeline. This role focuses on delivering high-quality vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will drive scientific excellence in scaling automation capabilities from concept to operation, integrating analytics, and modeling into downstream workflows, and translating microscale insights into robust, scalable processes-ensuring processes are robust, scalable, and phase-appropriate for GMP manufacturing.

Key Responsibilities

  • Build state-of-the-art mechanistic and hybrid models that directly influence the development of LVV downstream processing, build operational efficiency by model-first and AI-enabled development strategies.
  • Apply core engineering concepts including mass transfer, fluid mechanics, and thermodynamics to build robust in silico process models.
  • Perform data analytics using ML algorithms for modelling and clustering to generate process insights.
  • Working closely with team to implement development and optimization of downstream processes including and not limited to: clarification (depth filtration, centrifugation), chromatography (AEX, SEC, HIC), and Tangential Flow Filtration (TFF) for concentration and diafiltration.
  • Direct the translation of bench-scale processes to GMP manufacturing by simulation plus wet lab, ensuring seamless technology transfer and providing troubleshooting support during clinical production runs.
  • Design/ Implement different Advanced Process Control (APC) strategy (e.g., MPC, State Estimators) to optimise process performance.
  • Communicate the potential for issues and delays along with solutions and mitigation approaches.
  • In collaboration with the Senior Leaders, CMC Project Manager, Project Leader, and other technical leads identify project acceleration opportunities.
  • Leverage advanced science and technology to maximize vector recovery, purity, and potency, identifying creative solutions to define unknowns in the viral vector field.
  • Guide a team of scientists in the execution of project-specific activities, fostering a culture of transparency, scientific rigor, and continuous improvement.
  • Author and serve as a primary reviewer for technical documents, including development reports, SOPs, and CMC sections for regulatory submissions (IND/IMPD).
  • Work closely with Upstream Process Development and Analytical Development teams to ensure integrated and holistic process outcomes.
  • Tech transfer process to/from other Legend sites or CDMOs
  • Resolve conflict and proactively identify/address performance issues.
  • Ensure compliance with regulatory requirements.

Requirements

  • Advanced degree (PhD preferred, or MS) in Chemical Engineering, Biomedical Engineering, bioprocessing engineering or a related field.
  • 8+ years (PhD) or 10+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting.
  • Strong engineering knowledge of the bioprocessing modeling/simulation and the interaction of biomolecules, materials and machinery.
  • Experience with modeling software and programming language such as Python and MATLAB.
  • Deep technical experience in purification, chromatography, and TFF. 
  • Strong understanding of GMP manufacturing requirements and CMC strategies for early-phase and late phase clinical trials. 
  • Deep knowledge in lentiviral vector technologies within the current emerging field
  • Excellent leadership, emotional intelligence, and communication skills; ability to maintain composure and strategic focus during challenging development timelines.
  • Creative, strategic thinking
  • Strong troubleshooting skills
  • Preferred experience in developing vector processes tailored for in vivo CAR-T generation and systemic delivery
  • Preferred experience in large scale(>50L) purification process
  • Language(s): English. Mandarin is a plus

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