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Internship Downstream Process Development Scientist Jobs in Worcester, MA

Repligen Corporation

Scientist II

Waltham, MA · On-site

• The Scientist II, Downstream Processing will independently design, execute, and interpret ... Collaborate with product development, product management and field teams to support product ...

Repligen

Scientist II

Waltham, MA

The Scientist II, Downstream Processing will independently design, execute, and interpret studies ... Collaborate with product development, product management and field teams to support product ...

Danaher

Scientist / Engineer I, R&D

Marlborough, MA · On-site

$75K - $90K/yr

The Engineer/Scientist I is responsible for bioprocess development of new purification technologies ... Relevant industrial and/or research experience in downstream processing. Filtration experience ...

Danaher

Scientist / Engineer I, R&D

Marlborough, MA · On-site

$75K - $90K/yr

The Engineer/Scientist I is responsible for bioprocess development of new purification technologies ... Relevant industrial and/or research experience in downstream processing. Filtration experience ...

Repligen

Sr. Associate Scientist

Marlborough, MA · On-site

The Sr. Associate Scientist is a hands-on R&D role focused on the development and evaluation of membrane-based separation technologies for downstream bio-processing, with an emphasis on ...

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All JobsDownstream Process Development Scientist JobsInternship Downstream Process Development Scientist JobsInternship Downstream Process Development Scientist Jobs in Worcester, MA

Internship Downstream Process Development Scientist information

See Worcester, MA salary details

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How much do internship downstream process development scientist jobs pay per hour?

As of Aug 8, 2026, the average hourly pay for internship downstream process development scientist in Worcester, MA is $38.58, according to ZipRecruiter salary data. Most workers in this role earn between $28.32 and $46.06 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an internship downstream process development scientist, and why are they important?

To thrive as an Internship Downstream Process Development Scientist, you need foundational knowledge in biochemistry, molecular biology, or chemical engineering, often supported by ongoing or recent enrollment in a relevant degree program. Familiarity with laboratory techniques such as chromatography, filtration, and analytical instruments, as well as experience with lab management software, is typically expected. Attention to detail, problem-solving abilities, and effective teamwork are standout soft skills in this role. These skills and qualifications are crucial for conducting reliable experiments, analyzing data, and contributing to the optimization of bioprocesses in a collaborative research environment.

What does an internship downstream process development scientist do?

An Internship Downstream Process Development Scientist works in the biopharmaceutical industry, assisting with the development and optimization of processes that purify biological products such as proteins, antibodies, or vaccines after they are produced by cells. Their role often involves supporting laboratory experiments, analyzing samples, and documenting results to improve the efficiency and scalability of downstream processes like filtration and chromatography. Interns in this position gain hands-on experience with cutting-edge technologies and learn about regulatory requirements and industry standards. This role helps prepare students or recent graduates for a career in process development or biomanufacturing.

What types of projects and responsibilities can an internship downstream process development scientist expect to work on?

As an Internship Downstream Process Development Scientist, you can expect to be involved in hands-on laboratory work focusing on the purification and characterization of biopharmaceutical products. Typical responsibilities include preparing buffer solutions, operating chromatography and filtration systems, analyzing samples using various analytical techniques, and documenting experimental results. Interns often collaborate with experienced scientists and engineers, contributing to process optimization and troubleshooting. The role provides valuable exposure to industry-standard procedures and the opportunity to develop technical skills in a team-oriented environment.
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Internship Downstream Process Development Scientist jobs near you
Infographic showing various Internship Downstream Process Development Scientist job openings in Worcester, MA as of July 2026, with employment types broken down into 1% As Needed, 80% Full Time, 15% Part Time, and 4% Contract. Highlights an 91% Physical, 2% Hybrid, and 7% Remote job distribution, with an average salary of $80,245 per year, or $38.6 per hour.

Senior Scientist, LNP, Process Development & Manufacturing

ElevateBio

Waltham, MA • On-site

$98K - $134K/yr

Full-time

Posted 16 days ago

Job description

ElevateBio is a technology-driven company powering the industry forward by helping partners realize the potential of their therapies from design to commercialization. We have integrated a differentiated set of technologies, end-to-end services, and industry-leading manufacturing expertise to develop advanced therapies faster and more efficiently.
The Role:
We are seeking a highly skilled LNP Senior Scientist to join our process development team at ElevateBio. The ideal candidate will have hands-on experience in LNP formulation, targeted LNP (tLNP) engineering through bioconjugation, and a complete understanding of LNP-based processes. As an LNP Scientist, you will be responsible for designing and executing LNP formulation studies while also working closely with cross-functional teams and external clients for the manufacturing of LNP-based therapeutics. Your work will be critical in advancing the translation of LNP therapeutics from development through large-scale manufacturing at ElevateBio.
Here's What You'll Do:
  • Lead the execution for LNP formulation studies to support process characterization, technology transfer, and manufacturing readiness for LNP-based drug products.
  • Work closely with cross-functional teams, including MSAT, AD, Quality, Manufacturing, and external clients, to support process development, scale-up and technology transfers.
  • Characterize LNP and tLNP formulations using analytical techniques to evaluate size, PDI, zeta potential, encapsulation efficiency, lipid quantification, ligand density, conjugation efficiency, and formulation stability.
  • Analyze and interpret experimental data, identify process improvement opportunities, and communicate technical findings, project updates, and recommendations to internal stakeholders and external clients.
  • Provide strong support to the commercial team by evaluating work packages and proposals to attract potential clients looking to manufacture LNP-based drug products

Requirements:
Education Requirements
  • Ph.D. in Pharmaceutical Sciences, Bioengineering, Biochemistry, Chemical Engineering, Biotechnology, Biomedical Engineering or a related discipline with 5+ years of industry experience in lipid nanoparticle (LNP) development or drug delivery, or a BS/MS degree in a related field with 12+ years of relevant industry experience. Minimum of 6 years working with LNP-based products in a process development or manufacturing setting.

Experience Requirements
  • Familiarity with GMP regulations, regulatory expectations, and preparation of technical documentation supporting CMC activities, technology transfer, and regulatory filings for LNP-based formulated products
  • Proven record of manufacturing LNP-based products through either process development work or tech transfer activities
  • Strong understanding and practical experience with LNP formulation, process development, including scale-up into GMP manufacturing with demonstrated expertise in LNP formulation development & optimization, tLNP development, and LNP purification.
  • Ability to analyze and interpret data linking receptor engagement, ligand density, nanoparticle properties, cellular uptake, and delivery performance to guide tLNP optimization.
  • Experience with LNP analytical and biophysical characterization techniques such as dynamic light scattering (DLS), zeta potential, encapsulation efficiency assays (e.g., RiboGreen), lipid quantification, and stability assessments.
  • Experience operating automated LNP manufacturing and process development systems (e.g., PNI/Cytiva, Knauer) and filtration systems, including tangential flow filtration (TFF) platforms (e.g., Repligen)
  • Ability to analyze complex experimental data, troubleshoot process challenges, and collaborate cross-functionally with MSAT, analytical development, manufacturing, and external partners.

Preferred Qualifications
  • Experience with targeted LNP development, including ligand conjugation strategies, functionalization approaches, and characterization of targeted delivery systems.
  • Experience developing analytical methods for LNP characterization and release testing, including UPLC/HPLC-CAD for lipid analysis, payload quantification, and related analytical techniques.
  • Working knowledge of mRNA process development unit operations including in-vitro transcription (IVT), chromatography (Affinity, RP, IEX), and integration with LNP formulation processes.
  • Proficiency with statistical analysis software(e.g., JMP) and experience applying Design of Experiments (DoE) approaches and data-driven approaches to LNP formulation and process development.

The budgeted range for this position is $150,000 - $200,000. This range is a good faith estimate of the expected salary range for this position, based on a wide range of factors including qualifications, experience and training, operational and business needs and other considerations permitted by law.
ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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