Infrastructure Operations Manager Jobs in Pittsburgh, PA

Reporting directly to the COO, the Manager, Strategic Operations serves as a force multiplier for the leadership team, ensuring priorities translate into disciplined execution. This role is responsible for maintaining work management platforms, operational playbooks, financial and IT systems. The Manager, Strategic Operations will help build and sustain the operational backbone of the company. You will also work closely with the COO on internal communications, board and investor materials and core organizational workflows. This role requires exceptional attention to detail, strong judgment, and a commitment to high professional standards.

The most consequential decisions in public health, life sciences, insurance, and enterprise strategy share a common problem: they involve human behavior, network effects, and downstream effects that cannot be safely tested before action is taken. Traditional analytical techniques built on historical data were not built for this. Epistemix was.

We build simulation and data-driven modeling tools that let leaders visualize how strategies will unfold across populations and systems before they commit resources. By clarifying which variables drive outcomes, where leverage exists, and how they interact, we help organizations move from uncertainty to conviction. Getting these decisions right means faster interventions, better-allocated resources, and measurable improvements in human and economic outcomes. We exist to make that possible.

Our platform gives organizations access to realistic, high-resolution population data and the modeling infrastructure to run scenario planning at scale. Together, these capabilities let decision-makers stress-test strategies in a controlled environment before deploying them in the real world across healthcare, consumer industries, insurance, and government. We are approaching our Series B and actively building the team that will define what comes next.

Operational Infrastructure

• Organizational Systems: Support the COO in designing and maintaining internal systems that enable the organization to operate effectively. This includes shaping the structure of internal resources, playbooks, and working frameworks so that teams have clear guidance, consistent information, and easy access to the tools they need to execute.

• Institutional Knowledge: Maintain key internal resources so critical information, decisions, and processes remain visible, searchable, and easy for teams to navigate as the company grows.

• Execution & Change Management: Partner with the COO to lead internal initiatives, introducing improved ways of working, and supporting teams as new systems or operational practices are implemented. Review and refine internal resources, documentation, and operational frameworks to ensure they are consistent, practical, and aligned with the organization’s evolving needs.

Technology Operations

• Technology Operations: Oversee the day-to-day operational management of company technology systems, including employee access, licensing, and basic infrastructure coordination. This role will ensure team members have the tools and access they need to work effectively while maintaining appropriate controls as individuals join, transition within, or exit the organization.

• IT Vendor Management: Manage vendor relationships, prioritize requests, and ensure timely resolution of technology issues while maintaining high standards for responsiveness, reliability, and service quality.

• Technology Stewardship: Help ensure the organization maintains reliable and well-managed technology systems by coordinating data protection practices, backups, and continuity safeguards. This role will help ensure the company’s information assets remain secure, organized, and protected.

Financial Operations

• Financial Alignment: Serve as a key operational partner to the COO in maintaining financial visibility across the organization. Coordinate closely with the accounting team to track priorities, monitor open items, and ensure financial processes and operational decisions remain aligned.

• Budget Discipline: Assist the COO in supporting the organization’s commitment to disciplined financial management by monitoring spending across teams and ensuring financial practices remain consistent with company priorities.

• Expense & Travel Oversight: Oversee the company’s expense and travel processes to ensure they operate smoothly and in line with company standards. Maintain clear records, coordinate approvals where appropriate, and help ensure spending remains transparent, organized, and aligned with company expectations.

Leadership Operations & Strategic Coordination

• Board Meeting Coordination: Support the COO in coordinating the operational rhythm of the enterprise, leadership team and board engagement cycles. Help ensure materials, updates, and deliverables are organized, timely, and aligned with company priorities. Respond to inquiries from board members and investors in a timely and professional manner.

• Leadership Time Prioritization: Help maintain focus by supporting the coordination of leadership priorities and schedules. Ensure leadership time is directed toward the most important work, while maintaining clarity around competing demands and commitments.

• Events & Organizational Milestones: Coordinate the planning and execution of key company moments including leadership offsites, company gatherings, and industry events. Ensure events are thoughtfully organized and aligned with the company’s broader strategic and cultural objectives.

• Special Projects: Support high-priority initiatives led by the COO and leadership team by stepping in to advance urgent or complex workstreams, gathering information across teams, and ensuring important initiatives continue to move forward.

• Bachelors Degree or equivalent experience

• 5+ years of experience in Strategic Operations, Business Ops, or a high-level operational support role in a high-growth startup preferred.

• Demonstrated ability to lead complex projects and drive team adoption.

• Experience in software implementations and organizational change management.

• Comfort managing hardware logistics, software licenses, and basic troubleshooting.

• 2+ years of experience within a Series A or Series B stage company preferred.

• Deep experience in building complex databases, interconnected wikis, and project management hubs in Notion or similar software.

• Comfortable with accounting, budget tracking, and platforms like Ramp.

By joining Epistemix, you will become part of a collaborative and rapidly growing team that values curiosity and creativity. We are fully remote, with team members in the United States and Europe. Benefits include:

• Equity & Incentives – Participation in our stock option program.

• Flexible Time Off – Autonomy to manage your schedule and work-life balance.

• Health, Welfare and 401(k) Programs – Eligibility for benefits (for U.S. employees).

• Meaningful Impact – Apply your creative talents to revolutionize data-driven decision-making and make a real-world difference.

This is a remote position open to applicants located in the United States. Candidates must possess the legal right to work in their intended work location, as we are currently unable to sponsor or transfer employment visas for any country, including the United States.