Infrastructure Operations Manager Jobs in California

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

This is the operating leader for IT infrastructure and operations at Nurix, reporting to the SVP of Information Technology. You will own the function end to end: infrastructure, cybersecurity operations, end user services, and IT service management as one integrated scope. You partner with a fractional CISO on security strategy and policy while owning the operational execution. You work closely with the IT business partner leaders who own the application portfolios and partner directly with R&D and the broader scientific organization on their infrastructure needs.

You lead a team that spans enterprise architecture, system administration, and cybersecurity operations, with the service desk delivered through a mix of staff and managed service providers. You will manage both individual contributors and managers from day one. You set the standards and delegate delivery across this hybrid team of internal staff and managed service providers, empowering the people below you rather than running their queues, to support a fast-moving enterprise.

In your first year you will:

• Consolidate the managed service provider portfolio across infrastructure, security, and the help desk into a smaller, more accountable set of partners.
• Build a cybersecurity operations function from current contractor and MDR coverage.
• Establish a governance model with research and scientific computing, and bring research infrastructure into IT alignment. Working with the enterprise architect, inventory and remediate AWS systems: ParallelCluster and other HPC, container platforms (EKS, ECS), SageMaker, and identity bridges.
• Own a formal identity and access management program, including clean handoffs to IT operations and the business partner teams.
• Refresh the service experience end to end and raise vendor management discipline as scope grows.

• 12+ years of progressive technology services leadership, including 5+ years at the Director or Senior Director level.
• Direct experience leading multi-function technology services (infrastructure, cyber operations, and ITSM) as one integrated scope rather than separate towers.
• Comfort partnering with a CISO or fractional CISO on policy while owning operational execution. We are looking for an operator who builds security in partnership, not someone who pushes controls through operations.
• Deep experience across AWS plus the Microsoft Entra and Microsoft 365 stack.
• Familiarity with the infrastructure behind scientific and ML computing, AWS ParallelCluster and HPC, SageMaker, EKS and ECS, and DevOps and infrastructure-as-code practices, at a level sufficient to set standards and partner credibly with the scientific organization.
• A measurable track record managing a managed service provider portfolio, including real consolidation or vendor transitions with accountability for outcomes.
• Experience building out infrastructure in fast-moving, resource-constrained environments.
• Experience in a regulated industry (biotech, pharma, medical device, healthcare, financial services, or comparable).
• Bachelor's degree or equivalent practical experience.

• Biotech or pharmaceutical industry experience.
• Support for an FDA Pre-Approval Inspection or BIMO inspection in an IT or security capacity.
• Experience standing up a security operations function from contractor or MSP coverage.
• Partnership with a separate scientific computing organization (informatics, bioinformatics, cheminformatics, machine learning).
• Hands-on with an MDR provider such as RedCanary, Kroll, or Arctic Wolf.
• Jira Service Management or ServiceNow at scale.
• Public company SOX IT general controls experience.

• Strong team orientation; highly collaborative
• Ability to function in a dynamic environment
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range: $ 260K – $300K plus bonus and equity

Location: Brisbane, CA - Onsite

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