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From Home Variant Scientist Jobs (NOW HIRING)

Ambry Genetics

$110K - $114K/yr

The Clinical Genomic Scientist II is highly proficient in variant classification guidelines and in ... D. in Molecular Biology, Genetics, or related scientific field or MS in Genetic Counseling from an ...

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How much do from home variant scientist jobs pay per year?

As of Jul 5, 2026, the average yearly pay for from home variant scientist in the United States is $122,738.00, according to ZipRecruiter salary data. Most workers in this role earn between $98,500.00 and $136,000.00 per year, depending on experience, location, and employer.

What is the difference between From Home Variant Scientist vs From Home Data Analyst?

AspectFrom Home Variant ScientistFrom Home Data Analyst
Required CredentialsTypically a degree in chemistry, biology, or related field; often requires specialized certificationsUsually a degree in statistics, mathematics, or related field; certifications like CAP or Microsoft Power BI are common
Work EnvironmentLaboratory settings with remote data analysis; some roles are fully remotePrimarily remote, working with datasets, reports, and visualization tools
Industry UsagePharmaceuticals, biotech, research institutionsBusiness, finance, healthcare, marketing

From Home Variant Scientists focus on experimental research and data interpretation in scientific fields, often requiring lab experience, while From Home Data Analysts analyze datasets remotely to support business decisions. Both roles can be performed remotely but serve different industry needs and require distinct skill sets.

More about From Home Variant Scientist jobs
What cities are hiring for From Home Variant Scientist jobs? Cities with the most From Home Variant Scientist job openings:
What are the most commonly searched types of Variant Scientist jobs? The most popular types of Variant Scientist jobs are:
What states have the most From Home Variant Scientist jobs? States with the most job openings for From Home Variant Scientist jobs include:
What job categories do people searching From Home Variant Scientist jobs look for? The top searched job categories for From Home Variant Scientist jobs are:
From Home Variant Scientist jobs near you
Infographic showing various From Home Variant Scientist job openings in the United States as of June 2026, with employment types broken down into 17% As Needed, and 83% Contract. Highlights an 77% Physical, 1% Hybrid, and 22% Remote job distribution, with an average salary of $122,738 per year, or $59 per hour.
Principal Scientist, Bioinformatics Human Genetics

Principal Scientist, Bioinformatics Human Genetics

Genentech, Inc.

South San Francisco, CA • On-site

Full-time

Posted 16 days ago

Genentech rating

8.8

Company rating: 8.8 out of 10

Based on 22 frontline employees who took The Breakroom Quiz

10th of 73 rated pharmaceutical

Job description

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech.
Genentech's Department of Human Genetics sits at the center of our precision medicine strategy. We combine large-scale human genetic evidence with rich molecular, cellular, and clinical data to uncover causal disease biology and translate it into actionable targets, biomarkers, and patient stratification strategies.
THE OPPORTUNITY
We are seeking a Principal Scientist (Bioinformatics track) to lead cutting-edge statistical genetics and AI/ML-enabled "sequence-to-phenotype" research that directly accelerates target discovery and translation-particularly in Neuroscience (e.g., Multiple Sclerosis, Parkinson's disease, ALS). This is a methods-forward role for a scientist who thrives at the interface of human genetics, multimodal genomics, and machine learning, and who wants to see their work influence real therapeutic decisions.
In this role, you will:
  • Lead end-to-end human genetics analyses across array and sequencing cohorts, including rigorous QC, GWAS, fine-mapping, colocalization, gene prioritization, and rare-variant association (e.g., gene-based burden and variance-component approaches), with attention to multi-ancestry and bias/robustness.
  • Integrate genetics with functional and multimodal genomics, including single-cell and multiome (RNA/ATAC), molecular QTLs, and perturbation datasets to identify causal genes, implicated cell types/states, and mechanistic hypotheses.
  • Advance and operationalize AI/ML for genomics by evaluating and adapting modern sequence-to-function approaches for coding and noncoding variation-and critically, establishing reliability gating (calibration, uncertainty quantification, and robust benchmarking) so model outputs are decision-ready rather than purely exploratory.
  • Translate model outputs into genetics-ready quantities (e.g., fine-mapping priors, rare-variant weights, mechanism-linked scores) that improve discovery power and interpretability while enabling systematic, repeatable locus-to-biology workflows.
  • Anchor evaluation in experimental and real-world evidence, leveraging perturbation ground truth (e.g., reporter assays, CRISPR/base-editing studies, multiplex functional assays) and genetics/omics benchmarks to assess generalizability across cell states and datasets.
  • Build scalable, reusable software and workflows that make advanced genetics and AI methods broadly accessible-prioritizing reproducibility, documentation, and production-quality standards.
  • Provide scientific leadership and mentorship, partnering closely with cross-functional computational and experimental teams to shape strategy, communicate results clearly, and drive high-impact deliverables that inform research and development decisions.
  • Maintain scientific excellence through publications, conference presentations, and contributions to strategic external collaborations.

Example focus areas you may lead include:
  • Building a neuroscience-focused variant interpretation capability that links coding and noncoding variants to molecular function and disease-relevant phenotypes, with confidence scoring and integration into downstream genetics workflows.
  • Multiomic-first locus interpretation from fine-mapped signals to causal genes, cell states, and regulatory mechanisms
  • Structure-guided rare-variant discovery and interpretation frameworks
  • Genetics-informed patient stratification and biomarker development using deep phenotyping and clinically relevant outcomes

WHO YOU ARE
  • PhD in Statistical Genetics, Computational Biology, Bioinformatics, Biostatistics, Machine Learning, Computer Science, or a related quantitative field, followed by postdoctoral experience
  • Demonstrated scientific impact through high-quality peer-reviewed publications and conference presentations, with evidence of intellectual leadership (e.g., first/corresponding author)
  • Deep expertise in human/statistical genetics spanning common- and rare-variant methods, study design, and rigorous inference
  • Strong statistical and programming skills (e.g., Python and/or R) and commitment to reproducible science (version control, testing, workflow management, documentation)
  • Experience working with large-scale genomics datasets and modern compute environments (cloud and/or HPC)
  • Proven ability to lead complex, ambiguous scientific problems end-to-end and deliver robust solutions
  • Excellent communication and collaboration skills with the ability to influence across disciplines

PREFERRED
  • Demonstrated track record developing and/or scaling reusable analytics pipelines, platforms, or libraries used by multiple teams
  • Strong experience integrating genetics with single-cell/multiome data, molecular QTLs, functional genomics, and perturbation evidence
  • Applied experience with ML for genomics, including benchmarking, calibration/uncertainty, model reliability, and transfer/generalization assessment
  • Interest or prior experience in neuroscience, neuroimmunology, or neurodegeneration (helpful but not required)

Relocation benefits are available for this job posting.
The expected salary range for this position based on the primary location of California is $150,700 to $279,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

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About Genentech

Sourced by ZipRecruiter

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Industry

Scientific research and development services

Company size

10,000+ Employees

Headquarters location

South San Francisco, CA, US

Year founded

1976

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