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Role Location: Waltham, MA
The Company
We are Alloy Therapeutics - a biotechnology ecosystem and Product Development Organization (PDO) empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. May the Best Drug Win.
Alloy has evolved from a startup into a global product development organization operating 11 divisions across 5 research sites in 4 countries on 3 continents. Our model - Integrated Independence - combines centralized capabilities with entrepreneurial operating divisions. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.
At Alloy, we have an ethos of "Mentorship-By-Apprenticeship" in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day. We ask our people who have more flexible accommodations to appreciate their colleagues who have less flexibility. We are all one team!
About the Role at Alloy Therapeutics
As Head of Cell Line Development, you will lead technology evaluation, development, and strategy for stable cell line technologies. This is a senior leadership role responsible for shaping the scientific and technical direction of our cell line development capabilities, ensuring we remain at the forefront of innovation in stable transfection, clone selection, and cell line engineering.
This role will report directly to the CEO of the Antibody Powered Division in Waltham, MA, with autonomy owning various stakeholders, projects, and tasks in a dynamic start-up environment while keeping up the pace of Alloy.
How You'll Drive Impact

• Drive: Scientific direction and execution of cell line technology development projects.
• Innovate: Ensure the application of cutting-edge technologies and methodologies in cell line engineering.
• Collaborate: Integrate cell line development product offerings and engage with external collaborators in preparation of manufacturing of biologics.
• Deliver: Efficient execution of partner projects balancing quality, timelines, and costs, while ensuring successful completion of cell line producution that meet our partners' objectives.
• Lead: Marshall, inspire, and mentor a cross-functional team of scientists. Lead by example by going the extra mile to ensure we are successful delivering on projects.
• Communicate: Communicate effectively with key stakeholders externally and internally, fostering productive interactions both upward and downward, and across teams at different sites.

Key Responsibilities

• Lead technology evaluation and development strategy for stable cell line platforms, including host cell engineering, vector design, transfection methods, and clone screening/selection technologies
• Identify, assess, and implement next-generation technologies for stable transfection and cell line generation to improve titer, stability, product quality, and speed to clinic
• Set scientific strategy and roadmap for cell line development capabilities in alignment with broader organizational goals
• Stay current on emerging trends in stable cell line technologies (e.g., targeted integration, site-specific recombination, novel selection systems, high-throughput single-cell cloning, and next-gen expression platforms) and evaluate their applicability
• Represent the organization's cell line development capabilities in interactions with clients, partners, and at scientific conferences
• Develop and oversee IP strategy related to proprietary cell line technologies
• Ensure development activities meet relevant regulatory expectations (e.g., ICH Q5D) and support regulatory filings as needed
• Manage budgets, timelines, and resource allocation for cell line development programs

Required Qualifications

• Ph.D. in Cell Biology, Molecular Biology, Biochemical Engineering, or a related field
• 10+ years of hands-on experience in cell line development within a CDMO or pharmaceutical/biotech company setting
• Demonstrated proven track record of successfully developing and advancing stable mammalian cell lines (e.g., CHO) for biologics production
• Deep familiarity with current and emerging technologies for stable transfection and cell line generation (e.g., electroporation, lipofection, viral-mediated delivery, targeted integration systems, novel selection markers, high-throughput clone screening platforms)
• Strong understanding of clone selection, cell banking, stability testing, and characterization requirements (including regulatory expectations such as ICH Q5D)
• Experience leading teams and managing complex, multi-stakeholder technical programs
• Excellent communication skills, with experience presenting to internal leadership, clients, and/or regulatory bodies

Preferred Qualifications

• Prior experience evaluating or implementing novel cell line development platforms (e.g., targeted integration systems, next-generation expression vectors, single-cell dispensing/imaging technologies)
• Experience with GMP-regulated environments and technology transfer to manufacturing
• Track record of publications, patents, or conference presentations in cell line development
• Experience in a client-facing CDMO environment

Taking Care of Our People
We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you're single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.
Compensation

• Competitive base and equity compensation commensurate with level of experience and independence
• 401(k) company match

Health & Family

• Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
• Company-paid disability (STD, LTD) and life insurance
• Paid parental leave
• Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)

Unique Perks

• Unlimited PTO (paid time off) and flexible schedules
• Annual stipend for continuing education with commitment to your career through individualized professional development plan
• Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness

Pay Transparency
At Alloy Therapeutics, we believe in fostering trust and open communication. For this role, the estimated range is $150,000 - $215,000, with the final offer based on factors like your experience, skills, and alignment with our needs.
Additionally, this role is eligible for equity compensation, reflecting our commitment to shared success as we work together to make better medicines.
We are proud to offer competitive compensation and benefits, aiming to support our team's professional and personal well-being. If you have any questions about pay or benefits, we're here to help.
Alloy Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status. If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at [email protected]. We will make every effort to respond to your request for disability assistance as soon as possible.