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Enzyme Purification Jobs (NOW HIRING)

Princeton University

Research Specialist I

Princeton, NJ · On-site

$41K - $60K/yr

... purification of plasmid and genomic DNA from different organisms, restriction enzyme digests and gel electrophoresis of nucleic acids and recombinant DNA techniques, protein purification, and SDS gel ...

Princeton University

Research Specialist I

Princeton, NJ

$41K - $60K/yr

... purification of plasmid and genomic DNA from different organisms, restriction enzyme digests and gel electrophoresis of nucleic acids and recombinant DNA techniques, protein purification, and SDS gel ...

Uw

Research Scientist/Engr 1

Seattle, WA

$58K/yr

Protein production: bacterial expression, affinity purification, chromatography/FPLC workflows, and protein QC. Biochemical assays: experience with enzyme assays, transcription assays, fluorescence ...

Princeton University

Research Specialist I

Princeton, NJ · On-site

$41K - $60K/yr

... purification of plasmid and genomic DNA from different organisms, restriction enzyme digests and gel electrophoresis of nucleic acids and recombinant DNA techniques, protein purification, and SDS gel ...

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Enzyme Purification information

What is the difference between Enzyme Purification vs Protein Purification?

AspectEnzyme PurificationProtein Purification
CredentialsBiochemist, Molecular BiologistBiochemist, Molecular Biologist
Work EnvironmentLaboratories, biotech companiesLaboratories, biotech companies
Industry UsageEnzyme isolation for research and industrial useGeneral protein isolation for various applications
FocusIsolating and characterizing specific enzymesIsolating and analyzing diverse proteins

Enzyme Purification specifically involves isolating enzymes for research or industrial purposes, focusing on their activity and function. Protein Purification covers a broader range of proteins, including enzymes, structural proteins, and antibodies. While both roles require similar skills and work environments, enzyme purification emphasizes enzyme activity assays, whereas protein purification involves diverse techniques for different protein types.

What are some common challenges faced in enzyme purification roles, and how can they be addressed?

Professionals in enzyme purification often encounter challenges such as maintaining enzyme stability during extraction and purification, optimizing yield without compromising activity, and troubleshooting issues like protein aggregation or contamination. These challenges can be addressed by staying current with the latest techniques, regularly calibrating equipment, and collaborating closely with analytical and upstream processing teams. Effective communication and documentation are also crucial for resolving issues quickly and ensuring reproducibility in large-scale or GMP environments.

What is enzyme purification?

Enzyme purification is the process of isolating a specific enzyme from a complex mixture, such as a cell extract, to obtain it in a highly pure form. This typically involves a series of steps like centrifugation, filtration, precipitation, and chromatography to separate the enzyme from other proteins and contaminants. Purified enzymes are essential for research, industrial applications, and the development of diagnostic or therapeutic products.

What are the key skills and qualifications needed to thrive as an Enzyme Purification Specialist, and why are they important?

To thrive as an Enzyme Purification Specialist, you need a solid background in biochemistry or molecular biology, experience with protein purification techniques, and often a relevant bachelor's or advanced degree. Familiarity with chromatography systems (such as HPLC or FPLC), spectrophotometers, and analytical software is typically required. Attention to detail, problem-solving abilities, and effective communication are soft skills that help ensure accuracy and collaboration. These skills are crucial for producing high-purity enzymes efficiently, ensuring reproducible results, and supporting research or manufacturing objectives.
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Infographic showing various Enzyme Purification job openings in the United States as of July 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution.
Principal Process Engineer, ECO Synthesis

Principal Process Engineer, ECO Synthesis

Codexis

Redwood City, CA • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 6 days ago

Job description

We are seeking a highly experienced and innovative Process Engineer to support process development activities for Codexis' Enzyme Catalyzed Oligonucleotide (ECO) Synthesis manufacturing platform, driving innovation and scalability from bench to GMP production. This role is pivotal in advancing sustainable oligonucleotide manufacturing technologies that disrupt traditional chemical synthesis methods and meet stringent quality and regulatory standards.
If any of the below describes you, we would love to meet you!
  • Possess a passion for being part of the therapeutic community helping bring cutting edge treatments to patients in need. 
  • Enjoys collaboration across different functional groups to get a holistic understanding of process development along with aligning data with internal stakeholders.
  • Enjoys problem solving by implementing engineering and analytical solutions. 
  • Providing technical leadership in handson process development, applying advanced engineering principles to drive the design, buildout, and maturation of the ECO Synthesis platform in close partnership with crossfunctional development teams
  • Leading the scaleup strategy for the ECO Synthesis platform, ensuring process is robust, wellcharacterized, and ready for transition into a cGMP manufacturing environment.
  • Championing laboratory safety, maintaining a clean and compliant workspace, conducting process hazard analyses and risk assessments, and ensuring safe working environment for all team members.
  • Overseeing documentation quality, ensuring batch records, SOPs, and development reports meet GDP standards; providing mentorship and guidance to earlycareer engineers and scientists on documentation and experimental/statistical rigor.
  • Leading the development and delivery of key technical work, including internal and external presentations, detailed technical reports, and comprehensive technology transfer packages for siRNA manufacturing processes.
  • Owning the creation of engineering design tools, including mass and energy balances, process flow diagrams (PFDs), equipment specifications, and cost models to support scaleup, facility integration, and longterm platform deployment.
  • Serving as primary technical liaison with external vendors, driving equipment selection, qualification, and support activities essential for effective process development and scaleup.

Bachelor's degree in Chemical Engineering, Biochemical Engineering, or related field with 10+ years of relevant industrial experience, or M.S. with 8+ years.
Expertise in flow chemistry, biocatalysis, or oligonucleotide synthesis technologies (e.g., SPOS, enzymatic platforms).
Demonstrated leadership in scaleup activities, including tech transfer of biocatalytic or nucleic acid-based processes from laboratory to pilot or commercial manufacturing environments.
Proficiency in process modeling and simulation tools such as Aspen Plus, SuperPro Designer, COMSOL, or DynoChem; and proficient with data analytics or scripting tools (e.g., R, JMP, Python).
Strong leadership, communication skills, with the ability to collaborate effectively across cross-functional teams including R&D, Operations, Quality, and Engineering.
Additional experience that would be valuable for this role includes:
Prior experience managing early career engineers, scientist, or research associates.
Expertise in purification technologies, such as chromatography, filtration, or enzyme/oligonucleotide purification workflows.
Experience with facility design or equipment specification, for nucleic acid manufacturing.
Deep understanding of quality systems and regulatory expectations, including ISO-based quality frameworks and GMP principles.

  • Medical, Dental and Vision Insurance 
  • Basic Life, AD&D, Short- and Long-Term Disability Insurance 
  • 401k with Company Match up to 4% 
  • Company Equity 
  • Generous Paid Time Off including 18 Company Holidays (with a summer and winter shutdown), Vacation, and Wellness Time 
  • Annual Lifestyle Account for reimbursement of fitness programs, equipment and more 
  • Employee Stock Purchase Program (ESPP) 
  • Flexible Spending Accounts (Commuter/Parking, Dependent Care & Healthcare)
  • Student Debt Program (Company Contribution to Loans)
  • Mental Health Wellness Program
  • Subsidized onsite lunch program
  • Onsite Gym Facilities
  • Paid Parental Leave
And More!

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