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Enzyme Purification Jobs (NOW HIRING)

Fortive

Staff Scientist

Irvine, CA · On-site

Collaborate on the studies for enzyme purification and activity control with biochemistry SME * Execute product and test method development and validation, in support of production commercialization ...

Fortive

Staff Scientist

Irvine, CA · On-site

Collaborate on the studies for enzyme purification and activity control with biochemistry SME * Execute product and test method development and validation, in support of production commercialization ...

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Enzyme Purification information

What is the difference between Enzyme Purification vs Protein Purification?

AspectEnzyme PurificationProtein Purification
CredentialsBiochemist, Molecular BiologistBiochemist, Molecular Biologist
Work EnvironmentLaboratories, biotech companiesLaboratories, biotech companies
Industry UsageEnzyme isolation for research and industrial useGeneral protein isolation for various applications
FocusIsolating and characterizing specific enzymesIsolating and analyzing diverse proteins

Enzyme Purification specifically involves isolating enzymes for research or industrial purposes, focusing on their activity and function. Protein Purification covers a broader range of proteins, including enzymes, structural proteins, and antibodies. While both roles require similar skills and work environments, enzyme purification emphasizes enzyme activity assays, whereas protein purification involves diverse techniques for different protein types.

What are some common challenges faced in enzyme purification roles, and how can they be addressed?

Professionals in enzyme purification often encounter challenges such as maintaining enzyme stability during extraction and purification, optimizing yield without compromising activity, and troubleshooting issues like protein aggregation or contamination. These challenges can be addressed by staying current with the latest techniques, regularly calibrating equipment, and collaborating closely with analytical and upstream processing teams. Effective communication and documentation are also crucial for resolving issues quickly and ensuring reproducibility in large-scale or GMP environments.

What is enzyme purification?

Enzyme purification is the process of isolating a specific enzyme from a complex mixture, such as a cell extract, to obtain it in a highly pure form. This typically involves a series of steps like centrifugation, filtration, precipitation, and chromatography to separate the enzyme from other proteins and contaminants. Purified enzymes are essential for research, industrial applications, and the development of diagnostic or therapeutic products.

What are the key skills and qualifications needed to thrive as an Enzyme Purification Specialist, and why are they important?

To thrive as an Enzyme Purification Specialist, you need a solid background in biochemistry or molecular biology, experience with protein purification techniques, and often a relevant bachelor's or advanced degree. Familiarity with chromatography systems (such as HPLC or FPLC), spectrophotometers, and analytical software is typically required. Attention to detail, problem-solving abilities, and effective communication are soft skills that help ensure accuracy and collaboration. These skills are crucial for producing high-purity enzymes efficiently, ensuring reproducible results, and supporting research or manufacturing objectives.
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Enzyme Purification jobs near you
Infographic showing various Enzyme Purification job openings in the United States as of June 2026, with employment types broken down into 48% Full Time, 40% Part Time, 4% Temporary, and 8% Contract. Highlights an 60% Physical, 1% Hybrid, and 39% Remote job distribution.

Bioprocess Development Scientist

Syntis Bio

Boston, MA

Full-time

Medical, Dental, Vision, Life, Retirement

Posted 5 days ago

Job description

Syntis Bio is a clinical-stage biopharmaceutical company developing oral therapies that harness the small intestine’s unique biology to provide more accessible, effective and sustainable solutions across the healthcare spectrum, from rare genetic disorders to the world’s most prevalent conditions. Syntis is rapidly advancing a pipeline of oral therapies engineered for optimization in the small intestine, the body’s nexus for metabolic control, digestion and drug absorption. The company’s lead program, SYNT-101, is a once-daily oral pill for the treatment of obesity that mimics the effects of gastric bypass surgery. SYNT-101 leverages the power of SYNT™ (SYN thetic T issue-li ning), an oral technology developed by Syntis founders that delivers a safe, transient polymer coating to the duodenum that controls nutrient uptake, as well as enhances both gut-restricted enzyme efficacy and systemic drug absorption for up to 24 hours. The company is also developing a portfolio of enzyme replacement therapies to treat orphan metabolic and broad digestive disorders. Syntis is headquartered in Boston and has raised >$50 million to date from leading life sciences and strategic investors, as well as non-dilutive grant funding. For more information, please visit www.syntis.bio and follow us on LinkedIn.

Your Impact at Syntis: We are developing therapeutic enzymes for metabolic disorders for delivery with a novel drug delivery technology, SYNT.SYNT is a mucoadhesive polymer formed in vivo in the gastrointestinal tract that can be used to increase the intestinal residence time allowing improved efficacy of orally delivered enzymes. Syntis Bio is seeking a scientist to lead the upstream and downstream process development of the enzymes to be delivered with this technology. This role will be essential in driving advancement of multiple programs into early phase clinical studies. In addition, the scientist will work with the regulatory, nonclinical, formulation development, and clinical teams, as well as external partners. The role is on-site and located in Dorchester in Boston, MA.

The Responsibilities:

  • Lead the implementation of upstream processes for microbial fermentation and downstream processes for harvesting, cell lysis, and enzyme purification at CDMOs.
  • Management of CDMOs for tech transfer, process development, analytical development, and GMP manufacturing.
  • Implementation of analytical methods for establishing purity and activity of enzymes and execution of methods to support formulation development of the enzymes incorporated into the SYNT technology.
  • Support CMC Drug Substance sections of regulatory filings including INDs, BLAs, and NDAs.
  • Interpret, analyze, present, and properly record data.
  • Prepare documents and presentations that encompass project progression.

The Ideal Skills:

  • PhD (with 1-3 years work experience) or B.S./M.S. (with 8+ years of work experience) in chemical/biological engineering, biochemistry, or related discipline (level will be commensurate with experience).
  • Experience with management of CDMOs through process development, analytical development, and GMP manufacturing.
  • Experience with microbial fermentation including process scaleup.
  • Experience with cell lysis and purification operations such as homogenization, flocculation, depth filtration, tangential flow filtration, and chromatography including process scaleup.
  • Experience with a wide range of analytical techniques for characterization of enzymes including RP-HPLC and SE-HPLC.
  • Scientifically driven to overcome complex technical challenges during process development and scaleup.
  • Strong record of deliberate mentorship or management of junior level staff.
  • Proven ability to lead the scientific direction of a project.
  • Strong written and oral communication skills for technical and non-technical audiences.
  • Conscientious team member with experience taking and giving constructive feedback.

Syntis Bio is pleased to offer:

  • Medical, Dental, and Vision health plans.
  • Flexible time off.
  • Bonus and Equity plans.
  • Flexible Spending Account plan.
  • 401(k) retirement plan.
  • Short-Term Disability (STD), Long-Term Disability (LTD), and Life Insurance Plans

We are an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind based on race, color, sex, religion, age, sexual orientation, gender identity, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by applicable laws.

Syntis Bio uses E-Verify to confirm the identity and employment eligibility of all new hires.

Seniority level
  • Mid-Senior level
Employment type
  • Full-time
Job function
  • Research, Analyst, and Information Technology

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