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Enzyme Purification Jobs (NOW HIRING)

TALENT Software Services

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Sr Research Associate

San Rafael, CA · On-site

$35 - $43.75/hr

Independently perform purification of recombinant enzymes and other therapeutic biologics, including proteins, antibodies, and peptides, using ÄKTA Pure and ÄKTA Avant chromatography systems.

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Enzyme Purification information

What is the difference between Enzyme Purification vs Protein Purification?

AspectEnzyme PurificationProtein Purification
CredentialsBiochemist, Molecular BiologistBiochemist, Molecular Biologist
Work EnvironmentLaboratories, biotech companiesLaboratories, biotech companies
Industry UsageEnzyme isolation for research and industrial useGeneral protein isolation for various applications
FocusIsolating and characterizing specific enzymesIsolating and analyzing diverse proteins

Enzyme Purification specifically involves isolating enzymes for research or industrial purposes, focusing on their activity and function. Protein Purification covers a broader range of proteins, including enzymes, structural proteins, and antibodies. While both roles require similar skills and work environments, enzyme purification emphasizes enzyme activity assays, whereas protein purification involves diverse techniques for different protein types.

What are some common challenges faced in enzyme purification roles, and how can they be addressed?

Professionals in enzyme purification often encounter challenges such as maintaining enzyme stability during extraction and purification, optimizing yield without compromising activity, and troubleshooting issues like protein aggregation or contamination. These challenges can be addressed by staying current with the latest techniques, regularly calibrating equipment, and collaborating closely with analytical and upstream processing teams. Effective communication and documentation are also crucial for resolving issues quickly and ensuring reproducibility in large-scale or GMP environments.

What is enzyme purification?

Enzyme purification is the process of isolating a specific enzyme from a complex mixture, such as a cell extract, to obtain it in a highly pure form. This typically involves a series of steps like centrifugation, filtration, precipitation, and chromatography to separate the enzyme from other proteins and contaminants. Purified enzymes are essential for research, industrial applications, and the development of diagnostic or therapeutic products.

What are the key skills and qualifications needed to thrive as an Enzyme Purification Specialist, and why are they important?

To thrive as an Enzyme Purification Specialist, you need a solid background in biochemistry or molecular biology, experience with protein purification techniques, and often a relevant bachelor's or advanced degree. Familiarity with chromatography systems (such as HPLC or FPLC), spectrophotometers, and analytical software is typically required. Attention to detail, problem-solving abilities, and effective communication are soft skills that help ensure accuracy and collaboration. These skills are crucial for producing high-purity enzymes efficiently, ensuring reproducible results, and supporting research or manufacturing objectives.
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Enzyme Purification jobs near you
Infographic showing various Enzyme Purification job openings in the United States as of July 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution.
Scientist II, Protein Expression and Purification

Scientist II, Protein Expression and Purification

Foresite Labs

San Diego, CA • On-site

$110K - $120K/yr

Full-time

Posted 10 days ago

Job description

Scientist II, Protein Expression and Purification
Location: San Diego, CA
Job Type: Full-Time
Compensation: $110,000 to $120,000
About Us
We are a venture-backed, stealth-stage biotechnology company based in San Diego, focused on developing novel technologies that will redefine how disease is detected, characterized, and managed with a novel approach to clinical genomics. Our mission is to fundamentally transform healthcare through a convergence of innovation across multiple scientific disciplines.
Founded by industry veterans with decades of experience in life sciences tools and diagnostics, our leadership team brings a proven track record of translating scientific insight into successful commercial products. Our investors include some of the most respected names in healthcare and deep tech.
Position Overview
We are seeking a Scientist II, Enzyme Assay & Characterization to play a key role in developing and executing biochemical assays that support the company's multi-omics platform development. This individual will optimize and implement assays.
The Scientist II will contribute directly to enzyme evaluation. This role offers opportunities for broad technical growth, including assay development, molecular biology, protein engineering and integration.
The candidate must be detail-oriented, analytical, and collaborative, thriving in a dynamic environment that values innovation, cross-disciplinary interaction, and scientific rigor.
Key Responsibilities
• Clone, express, and screen protein constructs in bacterial expression systems.
• Optimize bacterial expression conditions.
• Execute purification workflows.
• Characterize protein quality.
• Optimize and implement biochemical assays.
• Develop, optimize, and validate spectroscopic and fluorescence-based assays.
• Troubleshoot and refine assays for reproducibility, sensitivity, and throughput.
• Collaborate closely with protein expression/purification, enzymology, protein engineering, and molecular biology teams.
• Document methods, maintain rigorous records, contribute to SOPs and prepare data summaries and reports.
• Support lab organization, maintain equipment, and ensure compliance with safety and reproducibility practices.
Qualifications
Required
• B.S. in Biochemistry, Molecular Biology, Enzymology, or related field with 4-6 years
of relevant experience, OR M.S. with 2-4 years of relevant experience.
• Demonstrated experience optimizing and implementing biochemical assays.
• Hands-on experience with spectroscopic and fluorescence-based assays.
• Hands-on experience with gel electrophoresis and gel-based assays.
• Strong experience with data visualization software.
• Excellent organizational, problem-solving, and communication skills.
• Ability to work independently and collaboratively in cross-functional teams.
Why Join Us
• Influence the foundational technologies and strategies of a company poised to shape the future of clinical genomics and healthcare.
• Work in a dynamic, collaborative environment where innovation and scientific rigor are deeply valued.
• Join a seasoned and multidisciplinary team tackling high-impact problems at the intersection of science and engineering.
• Competitive compensation and equity package, comprehensive benefits, and flexibility to support work-life integration.
We are an equal opportunity employer. We thrive on diversity and collaboration.

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