ZipRecruiter

Log In

1

Downstream Process Jobs in New York (NOW HIRING)

Neion Bio

Head of Biologics Development & CMC

Manhattan, NY · On-site

$170K - $230K/yr

This person will own Neion Bio's protein development and CMC strategy, spanning downstream process development, analytical development, product characterization, and regulatory CMC. This is a role ...

Neion Bio

Head of Biologics Development & CMC

New York, NY · On-site

$170K - $230K/yr

This person will own Neion Bio's protein development and CMC strategy, spanning downstream process development, analytical development, product characterization, and regulatory CMC. This is a role ...

Neion Bio

Head of Biologics Development & CMC

Manhattan, NY · On-site

$170K - $230K/yr

This person will own Neion Bio's protein development and CMC strategy, spanning downstream process development, analytical development, product characterization, and regulatory CMC. This is a role ...

MSD

Manager, Process Operations

Rahway, NJ

Lead a team executing upstream and downstream production operations. * Assign daily work and ensure effective execution, accountability, and compliance. * Drive cGMP and EHS compliance and promote a ...

Merck & Co.

Manager, Process Operations

Rahway, NJ · On-site

The Biologics Process Research & Development organization within our Company Research Labs is ... Lead a team executing upstream and downstream production operations.Assign daily work and ensure ...

next page

Showing results 1-20

All JobsDownstream Process JobsDownstream Process Jobs in New York

Downstream Process information

See New York salary details

$14

$26

$38

How much do downstream process jobs pay per hour?

As of Aug 2, 2026, the average hourly pay for downstream process in New York is $26.99, according to ZipRecruiter salary data. Most workers in this role earn between $21.59 and $30.77 per hour, depending on experience, location, and employer.

What are some common challenges faced by professionals working in downstream process roles within biomanufacturing?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a Downstream Process in biotechnology?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.
What are popular job titles related to Downstream Process jobs in New York? For Downstream Process jobs in New York, the most frequently searched job titles are:
What job categories do people searching Downstream Process jobs in New York look for? The top searched job categories for Downstream Process jobs in New York are:
What cities in New York are hiring for Downstream Process jobs? Cities in New York with the most Downstream Process job openings:
Downstream Process jobs near you
Infographic showing various Downstream Process job openings in New York as of July 2026, with employment types broken down into 18% Locum Tenens, 74% Full Time, 4% Part Time, 3% Contract, and 1% Summer. Highlights an 87% Physical, 3% Hybrid, and 10% Remote job distribution, with an average salary of $56,144 per year, or $27 per hour.

Principal Engineer, Lentivirus Downstream Process Development

Legend Biotech US

Somerset, NJ

Other

Posted 3 days ago

New

Job description

Legend Biotech is seeking a Principal Engineer, Lentivirus Downstream Process Development as part of the Technical Development team based in Somerset, NJ. 

Role Overview

The Principal Engineer, Lentivirus Downstream Process Development, will be a key technical leader responsible for designing, optimizing, and scaling purification processes for lentiviral vectors (LVV) within our
innovative pipeline. This role focuses on delivering high-quality vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will drive scientific excellence in downstream processing (DSP)-including clarification, chromatography, TFF, sterile filtration and fill/finish-ensuring processes are robust, scalable, and phase-appropriate for GMP manufacturing. This position demands a blend of hands-on technical mastery and strategic thinking to accelerate timelines while maintaining a patient-focused approach.

Key Responsibilities

  • Design and execute highly efficient purification strategies for lentiviral vectors, specifically optimized for CAR-T applications.
  • Direct the development and optimization of downstream processes including and not limited to: clarification (depth filtration, centrifugation), chromatography (AEX, SEC, HIC), and Tangential Flow Filtration (TFF) for concentration and diafiltration.
  • Provide hands-on training as needed.
  • Direct the translation of bench-scale processes to GMP manufacturing, ensuring seamless technology transfer and providing troubleshooting support during clinical production runs.
  • Lead the execution of study protocols to define operating parameters and performance limits; implement state-of-the-art knowledge management for DSP data.
  • Communicate the potential for issues and delays along with solutions and mitigation approaches.
  • In collaboration with the Senior Leaders, CMC Project Manager, Project Leader, and other technical leads identify project acceleration opportunities.
  • Leverage advanced science and technology to maximize vector recovery, purity, and potency, identifying creative solutions to define unknowns in the viral vector field.
  • Guide a team of scientists in the execution of project-specific activities, fostering a culture of transparency, scientific rigor, and continuous improvement.
  • Author and serve as a primary reviewer for technical documents, including development reports, SOPs, and CMC sections for regulatory submissions (IND/IMPD).
  • Work closely with Upstream Process Development and Analytical Development teams to ensure integrated and holistic process outcomes.
  • Tech transfer process to/from other Legend sites or CDMOs.
  • Resolve conflict and proactively identify/address performance issues.
  • Ensure compliance with regulatory requirements.

Requirements

  • Advanced degree (PhD preferred, or MS) in Chemical Engineering, Biomedical Engineering, bioprocessing engineering or a related field.
  • 8+ years (PhD) or 10+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting.
  • Strong engineering knowledge of the principles of scaledown model and the interaction of biomolecules, materials and machinery.
  • Deep technical hands-on experience in purification, chromatography, and TFF specifically for viral vectors (Lentivirus preferred).
  • Strong understanding of GMP manufacturing requirements and CMC strategies for early-phase clinical trials.
  • Deep knowledge and hands-on experiences in cell and lentiviral vector technologies within the current emerging field.
  • Ability to implement closed-system processes and maximize cost effectiveness.
  • Excellent leadership, emotional intelligence, and communication skills; ability to maintain composure and strategic focus during challenging development timelines.
  • Creative, strategic thinking.
  • Strong troubleshooting skills.
  • Preferred experience in developing vector processes tailored for in vivo CAR-T generation and systemic delivery.
  • Preferred experience in handling large scale(>50L) purification process.

#Li-JR1

#Li-Onsite

Apply