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Downstream Process Jobs in New York (NOW HIRING)

Head of Biologics

Manhattan, NY ยท On-site

$170K - $230K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

Lead Neion Bio's protein development function, including downstream process development, analytical development, product characterization, and regulatory strategy and interactions * Define product ...

Head of Biologics

New York, NY

$170K - $230K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

Lead Neion Bio's protein development function, including downstream process development, analytical development, product characterization, and regulatory strategy and interactions * Define product ...

Head of Biologics

Manhattan, NY ยท On-site

$170K - $230K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

Lead Neion Bio's protein development function, including downstream process development, analytical development, product characterization, and regulatory strategy and interactions * Define product ...

Director, CMC - Biologics & ADC

New York, NY ยท On-site

$210K - $250K/yr

This individual will own upstream and downstream process development, analytical development, and ADC conjugation/manufacturing - from early clinical supply through late-stage development - ensuring ...

This individual will own upstream and downstream process development, analytical development, and ADC conjugation/manufacturing -- from early clinical supply through late-stage development ...

Manager, Process Operations

Rahway, NJ

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Lead a team executing upstream and downstream production operations. * Assign daily work and ensure effective execution, accountability, and compliance. * Drive cGMP and EHS compliance and promote a ...

Manager, Process Operations

Rahway, NJ ยท On-site

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Lead a team executing upstream and downstream production operations. * Assign daily work and ensure effective execution, accountability, and compliance. * Drive cGMP and EHS compliance and promote a ...

Manager, Process Operations

Rahway, NJ ยท On-site

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Biologics Process Research & Development organization within our Company Research Labs is ... Lead a team executing upstream and downstream production operations.Assign daily work and ensure ...

Showing results 21-40

Downstream Process information

See New York salary details

$14

$26

$38

How much do downstream process jobs pay per hour?

As of Aug 20, 2026, the average hourly pay for downstream process in New York is $26.99, according to ZipRecruiter salary data. Most workers in this role earn between $21.59 and $30.77 per hour, depending on experience, location, and employer.

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What cities in New York are hiring for Downstream Process jobs?

Cities in New York with the most Downstream Process job openings:

Infographic showing various Downstream Process job openings in New York as of August 2026, with employment types broken down into 1% As Needed, 78% Full Time, 17% Part Time, 3% Contract, and 1% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $56,144 per year, or $27 per hour.

Biologics Process Research & Development, Associate Scientist

MSD

Rahway, NJ โ€ข On-site

Full-time

Medical, Dental, Vision, Retirement, PTO

This job post hasย expired today.ย Applications are no longer accepted.


Job description

Job Description

Biologics Process Research & Development (BPR&D) within our Company's Research Laboratories is on a mission to rapidly deliver biotherapeutics to patients by efficiently developing innovative, robust manufacturing processes and technologies. To achieve this, we work closely with colleagues in Discovery, Pre-clinical, Early Development, Analytical, Formulation, and Commercial Manufacturing while providing an inclusive environment for all. Beyond process development for pipeline biologics, we innovate and build next generation biomanufacturing technologies. Examples include investments for development of continuous manufacturing, green and sustainable processes, and proprietary technology platforms. We actively publish and engage with the scientific community to influence the field.

Biologics Process Research & Development (BPR&D) includes three lab-facing technical functional areas: Process Cell Sciences (PCS), Upstream and Downstream Process Development & Engineering. The latter two together form our Biologics' Process Development (BPD) group. This job posting covers opportunities for the BPD group. We are actively looking for highly motivated people with a passion for innovation and interest in contributing to upstream and/or downstream bioprocessing.

As an Associate Scientist in Biologics' Process Development(BPD) you will work with a highly collaborative team of scientists and engineers to design, develop and execute robust processes in support of early- to late-stage biological products. You will apply rigorous scientific principles to solve challenging problems focused on developing the best processes to deliver life-changing medicines to patients worldwide. You will also have an opportunity to contribute to additional areas of interest such as biophysical, process, economic and/or multivariate modeling as we are committed to leveraging digital ways of working to enhance our ability to design robust processes.

Responsibilities include but are not limited to:

Contribute to the development of innovative and disruptive technologies for next-generation biologic manufacturing processes

Develop and characterize robust clinical processes capable of delivering multi-kilogram quantities of drug substance

Independently design and conduct experiments for individual unit operations using relevant operational parameters and analytical inputs

Integrate unit operations both physically and with relevant process control and monitoring platforms for concurrent operations

Collaborate across the department, process analytics, and other functional teams in both Research & Development and manufacturing to advance the biologics pipeline

Conduct laboratory-scale and/or pilot-scale studies to support scale-up and tech transfer of processes

Contribute to a safe and compliant laboratory work environment

MINIMUM EDUCATION REQUIREMENTS:

Education:

BS (or expected completion within 6 months of application) in Chemical/Biochemical/Biomedical Engineering, Biotechnology, Biochemistry, Microbiology, Structural biology, or related fields

REQUIRED EXPERIENCE AND SKILLS:

Scientific understanding of the engineering principles for recombinant protein production unit operations.

Knowledge with aseptic technique, protein biophysical properties, and general protein laboratory practices

Strong passion and commitment to integrate science and innovation into biologics' process development

PREFERRED EXPERIENCE AND SKILLS:

Experience with molecular biology, protein expression, mammalian cell culture, protein purification, biochemical engineering, or protein analytical technologies

Knowledge of statistical data analysis tools such as the design of experiments and multivariate data analysis

#BPRD #PRD

Required Skills:

Bioprocesses, Biotechnology, Cell Cultures, Centrifugation, Chromatographic Techniques, Cross-Functional Teamwork, Data Analysis, Downstream Process Development, Evaluating New Technologies, Experimentation, Innovation, Laboratory Scales, Mammalian Cell, Mammalian Cell Culture, Membrane Filtration Systems, Microbiology, Molecular Microbiology, Process Scale Up, Protein Biochemistry, Protein Expression, Protein Purifications, Scientific Methods, Structural Biology, Technology Transfer

Preferred Skills:

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

The salary range for this role is

$71,900.00 - $113,200.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

No

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

N/A

Job Posting End Date:

09/1/2026

*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.