Director Variant Analyst Jobs (NOW HIRING)

We are seeking an exceptional senior leader with deep expertise in cancer genetics and genomics to join our team at the Regeneron Genetics Center. This Director-level role carries full accountability for the strategy and execution of cancer genetic product development - from aligning the vision with senior leadership and translating it into an actionable operational plan, through overseeing product development and setting the strategy for commercialization. The ideal candidate will bring a demonstrated track record of independence and impact, and will serve as the driving force for bringing cancer risk genomics into clinical and commercial reality.

In this role, a typical day might include the following:

Develop and deliver on cancer genetics testing opportunities, including germline testing partnerships, serving as the senior leader accountable for clinical cancer test development.

Define and own the end-to-end strategy for germline genetic cancer risk product development, translating organizational vision - aligned with senior leadership - into a clear, actionable operational roadmap with measurable milestones.

Develop and execute a comprehensive somatic genetics strategy for Regeneron's oncology portfolio, identifying new opportunities for somatic profiling studies across tumor types and leveraging existing cancer genomics databases.

Lead and execute large-scale somatic cancer sequencing analyses, including whole-exome and whole-genome sequencing of tumor samples, RNA-seq, and integrative multi-OMICS studies to identify driver mutations, therapeutic vulnerabilities, and mechanisms of resistance.

Design and contribute to cancer molecular profiling and clinical correlation analyses that integrate germline and somatic mutational profiles with multi-modal transcriptomic, epigenetic, and proteomic data to support target discovery, indication selection, and patient stratification strategies.

Oversee all phases of product development for cancer risk genomics programs, ensuring scientific rigor, cross-functional alignment, and on-time delivery against strategic objectives.

Develop and execute the commercialization strategy for RGC cancer products, identifying market opportunities, go-to-market pathways, and partnerships that maximize clinical and commercial impact.

Collaborate with and lead a multidisciplinary genetics team consisting of human genetics scientists, bioinformaticians, and statistical geneticists to design, execute, and interpret genetics studies related to cancer risk, somatic evolution, mechanisms, and therapeutic outcomes.

This job might be for you if you:

Have a demonstrated ability to independently own and drive strategic programs in cancer risk genomics or oncology product development from conception through commercialization.

Bring innovative thinking and hands-on leadership to large-scale somatic cancer sequencing studies and integrative genomic analyses.

Have deep expertise in analyzing tumor sequencing data, including variant calling, mutational signature analysis, clonal evolution, copy number alterations, and structural variant detection.

Have experience in developing or contributing to germline diagnostic tests for cancer predisposition, risk assessment, or clinical decision-making.

Are a motivated senior leader with a desire to pursue genetic discovery in a fast-paced multidisciplinary environment and can effectively guide teams and align stakeholders toward strategic goals.

Have demonstrated experience in quantitative problem solving, statistical analyses, and translating somatic and germline genetic findings into clinical applications.

To be considered for this role, you must have an MD or MD/PhD with a strong background in quantitative biology applied to cancer genetics and genomics, and a proven ability to design and lead large-scale human cancer genomic programs delivering medically- and commercially-relevant outcomes.

A minimum of 12 years of research experience in cancer genetics, genomics, or oncology product development is required, with a commensurate level of independence, seniority, and demonstrated responsibility for program strategy and execution.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed onsite. Please speak with your recruiter and hiring manager for more information about onsite expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)