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Contract Dmpk Jobs (NOW HIRING)

Actalent

Manager Bioanalytical

Cambridge, MA · Hybrid

$77 - $90/hr

... DMPK, TK, and PK/PD data evaluations across nonclinical and clinical development Ensure all ... Contract position based out of Cambridge, MA. Pay and Benefits The pay range for this position is ...

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Calibr

SENIOR DIRECTOR, TOXICOLOGY

San Diego, CA · On-site

Partner cross-functionally with Chemistry, Biology, DMPK, CMC, Regulatory, and Clinical teams to ... Oversee and manage multiple contract research organizations (CROs) supporting outsourced toxicology ...

Calibr

SENIOR DIRECTOR, TOXICOLOGY

San Diego, CA · On-site

Partner cross-functionally with Chemistry, Biology, DMPK, CMC, Regulatory, and Clinical teams to ... Oversee and manage multiple contract research organizations (CROs) supporting outsourced toxicology ...

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$106K

$139K

How much do contract dmpk jobs pay per year?

As of Jul 4, 2026, the average yearly pay for contract dmpk in the United States is $106,034.00, according to ZipRecruiter salary data. Most workers in this role earn between $89,000.00 and $119,000.00 per year, depending on experience, location, and employer.

What are some common challenges faced by Contract DMPK scientists when managing multiple client projects simultaneously?

Contract DMPK (Drug Metabolism and Pharmacokinetics) scientists often juggle several client projects at once, each with distinct timelines and requirements. Balancing priorities and maintaining clear communication with clients and internal teams is essential to ensure data integrity and meet deadlines. Additionally, adapting to varied study designs and regulatory expectations across projects can be demanding, requiring strong organizational skills and attention to detail. Effective project management and proactive problem-solving are key to thriving in this dynamic environment.

What are Contract DMPK positions?

Contract DMPK (Drug Metabolism and Pharmacokinetics) positions are temporary or project-based roles focused on studying how drugs are absorbed, distributed, metabolized, and excreted in the body. Professionals in these positions support pharmaceutical and biotechnology companies by conducting laboratory experiments, analyzing data, and helping optimize drug candidates. Contract roles may be full-time or part-time, and they often involve working with interdisciplinary teams to advance drug discovery and development projects.

What are the key skills and qualifications needed to thrive as a Contract DMPK (Drug Metabolism and Pharmacokinetics) Scientist, and why are they important?

To thrive as a Contract DMPK Scientist, you need a solid background in pharmacokinetics, drug metabolism, and analytical chemistry, typically supported by a degree in pharmaceutical sciences or a related field. Experience with laboratory instrumentation such as LC-MS/MS, data analysis software, and familiarity with regulatory guidelines (e.g., GLP, FDA) is essential. Strong problem-solving, attention to detail, and clear communication skills set top performers apart in this role. These skills ensure accurate data generation, compliance, and effective collaboration, all of which are critical for advancing drug development projects.

What is the difference between Contract Dmpk vs Contract Pharmacologist?

AspectContract DmpkContract Pharmacologist
Required CredentialsBachelor's or Master's in Pharmacology, DMPK-specific trainingBachelor's or Master's in Pharmacology or related field
Work EnvironmentLaboratories, research facilities, contract research organizations (CROs)Laboratories, research institutions, CROs
Industry UsageDrug development, pharmacokinetics studiesDrug development, pharmacodynamics, safety assessments
Common Search/ComparisonYesNo

Contract Dmpk specialists focus on pharmacokinetics and drug metabolism, while Contract Pharmacologists often work on drug effects and safety. Both roles are essential in drug development and share similar environments and credentials, but they differ in their specific focus areas within pharmacology.

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Contract Dmpk jobs near you
Principal Scientist, Medicinal Chemistry

Principal Scientist, Medicinal Chemistry

C4 Therapeutics Inc

Watertown, MA • On-site

$181K - $200K/yr

Full-time

Posted 23 days ago

Be an early applicant

Job description

About C4 Therapeutics:

C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases. C4T’s degrader medicines are designed to harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. For more information, please visit www.c4therapeutics.com.

Job Summary

We are seeking a motivated and innovative medicinal chemist to join a fast-paced, multidisciplinary team working on the development of targeted protein degradation therapeutics. In this role, you will provide medicinal chemistry leadership on small molecule heterobivalent and monovalent (glue) degrader projects. Your in-depth knowledge of medicinal chemistry and proven track record of problem solving, follow-through, and project completion. will be key to driving success in projects that advance small molecules across stage gates, from Hit Identification through clinical candidate nomination.


Your Role

  • Enables expeditious advancement of Structure Activity Relationships (SAR) through creative contributions to medicinal chemistry design, including effective collaboration with Biological Sciences, Computational Chemistry and Structural Biology colleagues.
  • Independently leads medicinal chemistry efforts on heterobivalent and/or monovalent degrader projects.
  • Manages external chemistry efforts at CROs (Contract Research Organizations).
  • Critically analyzes data and communicates findings effectively to multidisciplinary team members and leadership.
  • Communicates clear, focused, and transparent updates to project teams, internal departments, and senior leadership.
  • Makes broad scientific contributions that have a positive impact on the research direction of the company.
  • Contributes to and/or authors patents, scientific presentations, and publications.

Your Background

Required:

  • A PhD in organic and/or medicinal chemistry with a minimum of eight years of relevant biopharmaceutical or pharmaceutical experience in medicinal chemistry roles, with experience solving challenging problems in drug discovery through medicinal chemistry optimization.
  • Demonstrated expertise in synthetic organic chemistry, including methodologies, transformations, and mechanisms
  • Proven scientific track record of advancing small molecules through stage gate milestones, from Hit ID through candidate selection, including optimizing degraders, including ligand optimization in the presence (and/or absence) of structural data
  • Experience managing CRO chemistry efforts to ensure appropriate use of resources and timely delivery of compounds
  • Experience closely working with Drug Metabolism and Pharmacokinetic (DMPK) colleagues on the in vitro and in vivo optimization of DMPK parameters to progress compounds

Preferred:

  • Experience in working across multiple drug modalities, including ADC / DACs
  • Hands-on experience utilizing and implementing computational tools (Maestro, MOE, or similar) to the design of compounds and integration of computational data into a continual design-synthesize-test-data analysis cycle

Compensation

The base pay range for this position at commencement of employment is expected to be between $181,012.05 and $200,066.00 annually; however, base pay offered may vary depending on multiple individualized factors, including job-related knowledge, skills, and experience.


C4 Therapeutics is an Equal Opportunity Employer.