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Computer System Validation Manager Jobs in Pennsylvania

Compli

CSV Lead/ Computer System Validation Lead

Marietta, PA · On-site

$96K - $127K/yr

CSV Lead/ Computer System Validation Lead Location : Marietta, PA Compli, LLC was founded in 2001 to provide Commissioning, Validation and Regulatory Support Services to the Life Sciences industry.

GSK

Senior Validation Engineer

King Of Prussia, PA · On-site

Development of procedures, practices, and policies related to computer system validation. Monitor and update the Validation Master Plan to ensure that it complies with appropriate regulatory ...

Novocure

Digital Systems Validation Lead

Wayne, PA · On-site

$116K - $130K/yr

Master's degree preferred * 8+ years of experience in computer system validation within regulated ... Leadership experience managing and developing validation teams, governance frameworks, and scalable ...

Novocure Inc

Digital Systems Validation Lead

Wayne, PA · On-site

$116K - $130K/yr

Master's degree preferred * 8+ years of experience in computer system validation within regulated ... Leadership experience managing and developing validation teams, governance frameworks, and scalable ...

Novocure

Digital Systems Validation Lead

Wayne, PA · Hybrid

$116K - $130K/yr

Master's degree preferred * 8+ years of experience in computer system validation within regulated ... Leadership experience managing and developing validation teams, governance frameworks, and scalable ...

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All JobsComputer System Validation JobsComputer System Validation Manager JobsComputer System Validation Manager Jobs in Pennsylvania

Computer System Validation Manager information

See Pennsylvania salary details

$47.6K

$105.7K

$160.9K

How much do computer system validation manager jobs pay per year?

As of Jul 15, 2026, the average yearly pay for computer system validation manager in Pennsylvania is $105,668.00, according to ZipRecruiter salary data. Most workers in this role earn between $74,700.00 and $132,300.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Computer System Validation Manager, and why are they important?

To thrive as a Computer System Validation Manager, you need expertise in computer system validation regulations (such as GxP, FDA 21 CFR Part 11), strong project management skills, and a background in life sciences or IT. Familiarity with validation lifecycle documentation tools, quality management systems (QMS), and compliance software is often required, along with relevant certifications like PMP or CSV-related credentials. Exceptional attention to detail, analytical thinking, and effective communication are crucial soft skills for coordinating cross-functional teams and ensuring regulatory compliance. These skills and qualifications are vital to ensure validated systems meet regulatory standards, minimize compliance risks, and support organizational quality objectives.

What are some common challenges a Computer System Validation Manager faces during system implementation projects?

A Computer System Validation Manager often encounters challenges such as aligning validation activities with evolving regulatory requirements, managing tight project timelines, and coordinating between multiple stakeholders like IT, Quality Assurance, and business users. Ensuring thorough documentation and traceability, while adapting to technology updates or scope changes, can also be demanding. Proactive communication and strong project management skills are essential to mitigate risks and ensure successful, compliant system implementations.

What does a Computer System Validation Manager do?

A Computer System Validation Manager is responsible for ensuring that computer systems used in regulated industries, such as pharmaceuticals or biotechnology, meet all required compliance standards. They oversee the planning, execution, and documentation of validation activities to ensure systems are reliable, accurate, and secure. Their duties include managing validation projects, writing protocols, coordinating with IT and quality assurance teams, and ensuring adherence to regulations like FDA 21 CFR Part 11. This role is critical for maintaining product quality and regulatory compliance.

What is the difference between Computer System Validation Manager vs Computer System Validation Specialist?

AspectComputer System Validation ManagerComputer System Validation Specialist
CertificationsGAMP, CQE, CSQEGAMP, CQE, CSQE
Work EnvironmentManagement, oversight, strategic planningExecution, testing, documentation
Industry UsagePharmaceutical, biotech, regulated industriesPharmaceutical, biotech, regulated industries
Primary FocusLeading validation projects, team coordinationPerforming validation activities, testing

The main difference between a Computer System Validation Manager and a Computer System Validation Specialist lies in their roles. The manager oversees validation projects, manages teams, and ensures compliance, while the specialist executes validation tasks and documents testing procedures. Both roles require similar certifications and are vital in regulated industries like pharmaceuticals and biotech.

What are the most commonly searched types of Computer System Validation jobs in Pennsylvania? The most popular types of Computer System Validation jobs in Pennsylvania are:
What are popular job titles related to Computer System Validation Manager jobs in Pennsylvania? For Computer System Validation Manager jobs in Pennsylvania, the most frequently searched job titles are:
What job categories do people searching Computer System Validation Manager jobs in Pennsylvania look for? The top searched job categories for Computer System Validation Manager jobs in Pennsylvania are:
What cities in Pennsylvania are hiring for Computer System Validation Manager jobs? Cities in Pennsylvania with the most Computer System Validation Manager job openings:
Computer System Validation Manager jobs near you
Infographic showing various Computer System Validation Manager job openings in Pennsylvania as of July 2026, with employment types broken down into 1% As Needed, 77% Full Time, 17% Part Time, 1% Temporary, 3% Contract, and 1% Nights. Highlights an 78% Physical, 5% Hybrid, and 17% Remote job distribution, with an average salary of $105,668 per year, or $50.8 per hour.
Computer System Validation (CSV) Lead

Computer System Validation (CSV) Lead

Intellectt INC

Lancaster, PA • On-site

Contractor

Posted 25 days ago

Job description

Hello,

I hope you're doing well.

My name is Mahalakshmi, and I’m reaching out from Intellectt Inc. regarding an exciting contract opportunity for a Computer System Validation (CSV) Lead based in Lancaster, PA with one of our prestigious clients.
I would love to connect and discuss this opportunity in more detail. Please feel free to share your updated resume at mahalakshmi.n@intellectt.com  OR +1 (732) 737 8381

Job Title: Computer System Validation (CSV) Lead
Location: Lancaster, PA

Position Summary

We are seeking an experienced Computer System Validation (CSV) Lead to support validation activities for a newly constructed Sterile Drug Product Clinical Manufacturing Facility. This role will lead CSV strategy, execution, and compliance activities for GMP computerized systems and automation platforms in a fast-paced project environment.

Key Responsibilities

  • Lead CSV strategy and execution for GMP computerized systems and automation platforms.
  • Author and execute CSV lifecycle documents including Validation Plans, URS, Risk Assessments, IQ/OQ/PQ protocols, Traceability Matrices, and Summary Reports.
  • Support commissioning, qualification, and validation activities for manufacturing and automation systems.
  • Collaborate with Automation, Engineering, Quality, Manufacturing, and IT teams.
  • Lead deviation investigations, troubleshooting, and validation issue resolution.
  • Ensure compliance with GAMP5, 21 CFR Part 11, Data Integrity, and company validation standards.
  • Support testing and validation of control systems, SCADA/HMI platforms, instrumentation, OT infrastructure, and manufacturing equipment.

Required Qualifications

  • Bachelor’s degree in Engineering, Computer Science, Automation, Life Sciences, or related field.
  • 10–15 years of CSV, Automation, or Validation Engineering experience in pharmaceutical or biotech industries.
  • Strong experience in GMP manufacturing environments, preferably sterile or aseptic processing facilities.
  • Hands-on experience with CSV documentation, protocol execution, and validation lifecycle management.
  • Strong knowledge of GAMP5, 21 CFR Part 11, CSA/CSV methodologies, and Data Integrity principles.
  • Excellent technical writing, troubleshooting, and communication skills.

Preferred Technical Experience

  • AVEVA System Platform, Allen Bradley PLC, Siemens PLC, PI Historian, SCADA/HMI systems.
  • OT networks, instrumentation, industrial communications, and field I/O testing.
  • Experience with robotic isolators, filling lines, lyophilizers, autoclaves, and wash systems.
  • Kneat validation platform experience preferred.

Thanks & Regards,
Mahalakshmi
Junior Recruiter
Intellectt Inc 
mahalakshmi.n@intellectt.com
Direct: +1 (732) 737 8381