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Computer System Validation Manager Jobs in Philadelphia, PA

GenScript/ProBio

(Sr.) Validation Engineer

Pennington, NJ · On-site

$80K - $120K/yr

The position reports to the Sr. Validation Manager and is responsible for supporting commissioning ... Support facility, utility, equipment, process, cleaning, and computer system validation (CSV ...

Novocure

Digital Systems Validation Lead

Wayne, PA · On-site

$116K - $130K/yr

Master's degree preferred * 8+ years of experience in computer system validation within regulated ... Leadership experience managing and developing validation teams, governance frameworks, and scalable ...

Novocure

Digital Systems Validation Lead

Wayne, PA · Hybrid

$116K - $130K/yr

Master's degree preferred * 8+ years of experience in computer system validation within regulated ... Leadership experience managing and developing validation teams, governance frameworks, and scalable ...

Novocure Inc

Digital Systems Validation Lead

Wayne, PA · On-site

$116K - $130K/yr

Master's degree preferred * 8+ years of experience in computer system validation within regulated ... Leadership experience managing and developing validation teams, governance frameworks, and scalable ...

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All JobsComputer System Validation JobsComputer System Validation Manager JobsComputer System Validation Manager Jobs in Philadelphia, PA

Computer System Validation Manager information

See Philadelphia, PA salary details

$47.9K

$106.4K

$162K

How much do computer system validation manager jobs pay per year?

As of Aug 4, 2026, the average yearly pay for computer system validation manager in Philadelphia, PA is $106,373.00, according to ZipRecruiter salary data. Most workers in this role earn between $75,200.00 and $133,200.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a computer system validation manager, and why are they important?

To thrive as a Computer System Validation Manager, you need expertise in computer system validation regulations (such as GxP, FDA 21 CFR Part 11), strong project management skills, and a background in life sciences or IT. Familiarity with validation lifecycle documentation tools, quality management systems (QMS), and compliance software is often required, along with relevant certifications like PMP or CSV-related credentials. Exceptional attention to detail, analytical thinking, and effective communication are crucial soft skills for coordinating cross-functional teams and ensuring regulatory compliance. These skills and qualifications are vital to ensure validated systems meet regulatory standards, minimize compliance risks, and support organizational quality objectives.

What are some common challenges a computer system validation manager faces during system implementation projects?

A Computer System Validation Manager often encounters challenges such as aligning validation activities with evolving regulatory requirements, managing tight project timelines, and coordinating between multiple stakeholders like IT, Quality Assurance, and business users. Ensuring thorough documentation and traceability, while adapting to technology updates or scope changes, can also be demanding. Proactive communication and strong project management skills are essential to mitigate risks and ensure successful, compliant system implementations.

What does a computer system validation manager do?

A Computer System Validation Manager is responsible for ensuring that computer systems used in regulated industries, such as pharmaceuticals or biotechnology, meet all required compliance standards. They oversee the planning, execution, and documentation of validation activities to ensure systems are reliable, accurate, and secure. Their duties include managing validation projects, writing protocols, coordinating with IT and quality assurance teams, and ensuring adherence to regulations like FDA 21 CFR Part 11. This role is critical for maintaining product quality and regulatory compliance.

What is the difference between Computer System Validation Manager vs Computer System Validation Specialist?

AspectComputer System Validation ManagerComputer System Validation Specialist
CertificationsGAMP, CQE, CSQEGAMP, CQE, CSQE
Work EnvironmentManagement, oversight, strategic planningExecution, testing, documentation
Industry UsagePharmaceutical, biotech, regulated industriesPharmaceutical, biotech, regulated industries
Primary FocusLeading validation projects, team coordinationPerforming validation activities, testing

The main difference between a Computer System Validation Manager and a Computer System Validation Specialist lies in their roles. The manager oversees validation projects, manages teams, and ensures compliance, while the specialist executes validation tasks and documents testing procedures. Both roles require similar certifications and are vital in regulated industries like pharmaceuticals and biotech.

What are popular job titles related to Computer System Validation Manager jobs in Philadelphia, PA? For Computer System Validation Manager jobs in Philadelphia, PA, the most frequently searched job titles are:
What job categories do people searching Computer System Validation Manager jobs in Philadelphia, PA look for? The top searched job categories for Computer System Validation Manager jobs in Philadelphia, PA are:
What cities near Philadelphia, PA are hiring for Computer System Validation Manager jobs? Cities near Philadelphia, PA with the most Computer System Validation Manager job openings:
Computer System Validation Manager jobs near you
Infographic showing various Computer System Validation Manager job openings in Philadelphia, PA as of July 2026, with employment types broken down into 57% Full Time, and 43% Contract. Highlights an 100% In-person job distribution, with an average salary of $106,373 per year, or $51.1 per hour.

COMPUTER SYSTEM VALIDATION LEAD in Wilmington, DE

Northern Base

Wilmington, DE • On-site

Full-time

Posted 28 days ago

Job description

COMPUTER SYSTEM VALIDATION LEAD
Wilmington, DE
Fulltime
10+ years of experience
​
Must Have Technical/Functional Skill
•  8–10 years of experience in Computer System Validation (CSV) in regulated (GxP) environments (Pharma / Biotech / MedTech).
• Hands-on experience with validation deliverables: VMP/VP, URS/FS/DS, risk assessments, RTM, IQ/OQ/PQ protocols and reports.
• Strong knowledge of 21 CFR Part 11 and EU Annex 11; ALCOA+ data integrity principles.
• Experience validating SDLC/CSV across system types (e.g., LIMS, MES, QMS, ERP, DMS, Lab instruments, cloud/SaaS applications).
• Familiarity with GAMP 5 and risk-based validation approach.
• Ability to review vendor documentation, perform supplier assessments, and leverage vendor testing.
• Working knowledge of change control, deviation management, CAPA, and periodic review.
• Good documentation practices; strong stakeholder management and communication skills.
 
Roles & Responsibilities
•  Lead and execute end-to-end CSV activities across the validation lifecycle, ensuring compliance with applicable regulations and internal quality procedures.
• Perform system impact and risk assessments; define validation strategy, scope, and approach (risk-based).
• Author/review validation documentation (VP/VMP, URS, FS/DS, RA, RTM, protocols, reports) and ensure traceability from requirements to testing.
• Develop and execute IQ/OQ/PQ (or equivalent) test scripts; collect and review objective evidence; manage deviations and re-testing.
• Support system release and go-live readiness; ensure security, access control, audit trails, and electronic records/signature controls meet Part 11/Annex 11 expectations.
• Coordinate with IT, Quality, vendors, and business SMEs; review supplier documentation and leverage vendor testing where appropriate.
• Support change control activities (impact assessment, regression testing recommendations, validation closure) and periodic review/maintenance activities.
• Prepare for and support internal/external audits and inspections; respond to auditor queries and contribute to CAPA actions.
• Mentor junior CSV team members; contribute to process improvements, templates, and best practices.