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Clinical Operations Manager Jobs in Boston, MA (NOW HIRING)

Doist

Director, Clinical Operations

Boston, MA · On-site

$215 - $240/hr

Th is individual will manage trial budgets, vendor selection, and risk mitigation while ... Performs role of Clinical Operations trial lead for assigned trials and leads cross-functional ...

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Clinical Operations Manager information

See Boston, MA salary details

$38K

$106.5K

$202.6K

How much do clinical operations manager jobs pay per year?

As of Aug 21, 2026, the average yearly pay for clinical operations manager in Boston, MA is $106,508.00, according to ZipRecruiter salary data. Most workers in this role earn between $78,800.00 and $123,300.00 per year, depending on experience, location, and employer.

What is a clinical operations manager?

Clinical Operations Managers are professionals responsible for overseeing the day-to-day administrative and operational functions of clinical trials or healthcare facilities. They ensure that clinical protocols are followed, resources are efficiently allocated, and regulatory compliance is maintained. These managers coordinate between healthcare staff, researchers, and external partners to facilitate smooth clinical operations and high-quality patient care. Their role is essential in ensuring that clinical services or trials are delivered effectively, safely, and on schedule.

What does a clinical operations manager do?

A clinical operations manager or director is a health care professional who oversees the operations of a medical facility. Their duties include meeting regularly with department heads, reading assessments of employee productivity, and managing administrative tasks, such as budgeting and billing. Qualifications for a clinical operations manager include experience in medical administration, management skills, and organizational skills. An advanced degree in public health or health administration can significantly improve your job opportunities.

What are the key skills and qualifications needed to thrive as a clinical operations manager, and why are they important?

To thrive as a Clinical Operations Manager, you need expertise in clinical trial management, regulatory compliance, and healthcare operations, usually supported by a degree in a health-related field and relevant experience. Familiarity with clinical trial management systems (CTMS), electronic data capture (EDC) platforms, and certifications such as ACRP or SOCRA are commonly required. Strong leadership, problem-solving abilities, and effective communication are essential soft skills for this role. These skills ensure efficient trial execution, regulatory adherence, and successful coordination across teams and stakeholders.

What are the main challenges clinical operations managers face when overseeing multiple clinical trials simultaneously?

Clinical Operations Managers often juggle several clinical trials at once, which can present challenges such as maintaining consistent quality across studies, ensuring timely patient recruitment, and managing diverse teams. They must coordinate with cross-functional departments, address regulatory compliance, and troubleshoot unforeseen issues, all while staying on schedule and within budget. Effective organizational skills, proactive communication, and adaptability are essential for overcoming these challenges and ensuring successful trial outcomes.

What is the difference between Clinical Operations Manager vs Clinical Research Coordinator?

AspectClinical Operations ManagerClinical Research Coordinator
CredentialsBachelor's degree in health sciences, management experienceBachelor's degree in health or life sciences, research training
Work EnvironmentOversees multiple clinical trials, manages teamsAssists with daily trial activities, data collection
Employer & IndustryPharmaceutical companies, CROs, hospitalsResearch institutions, hospitals, clinical sites

The Clinical Operations Manager focuses on overseeing entire clinical trial operations, managing teams, and ensuring compliance. In contrast, the Clinical Research Coordinator handles the day-to-day activities at trial sites, such as patient recruitment and data collection. Both roles require related credentials and work within the clinical research industry, but their responsibilities and scope differ significantly.

More about Clinical Operations Manager jobs

What are the most commonly searched types of Clinical Operations jobs in Boston, MA?

The most popular types of Clinical Operations jobs in Boston, MA are:

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For Clinical Operations Manager jobs in Boston, MA, the most frequently searched job titles are:

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The top searched job categories for Clinical Operations Manager jobs in Boston, MA are:

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Clinical Operations Manager jobs near you
Infographic showing various Clinical Operations Manager job openings in Boston, MA as of August 2026, with employment types broken down into 1% As Needed, 82% Full Time, 12% Part Time, 1% Temporary, 3% Contract, and 1% Nights. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $106,508 per year, or $51.2 per hour.

Senior Clinical Operations Lead

Sarepta Therapeutics, Inc.

Cambridge, MA • On-site

Full-time

This job post has expired today. Applications are no longer accepted.

Job description

Why Sarepta? Why Now?
The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.
We're looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta Offers
At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
  • Physical and Emotional Wellness
  • Financial Wellness
  • Support for Caregivers

For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
The Importance of the Role
The Senior Clinical Operations Lead, Clinical Operations manages all aspects of assigned clinical trials as well as the study project plan, including timeline, budget, and vendors and is expected to conduct large studies of high complexity. The Sr. COL will provide leadership and potentially line management within Clinical Operations and guidance with regards to operational deliverables
The Opportunity to Make a Difference
• Oversees Clinical Research Organizations (CROs), vendors and consultants involved with the clinical trials
• Serves as the point of contact for protocol execution and leads the Clinical Trial Team (CTT)
• Mentors junior team members and ensures alignment with any supporting Clinical Operations
Leads (COLs) assigned to studies
• Establishes study timelines in line with company goals and ensures accurate tracking and reporting of study metrics and progress through completion of study dashboards
• Works cross-functionally to ensure clinical program timelines and goals are met and risks are appropriately escalated to the Clinical Operations Program Lead (COPL)
• Ensures trial adherence to ICH/GCP/Federal and local regulations and company specific SOPs
• Develops, reviews and/or consults on reports and clinical trial documents such as informed consent, clinical protocols, Investigator Brochure, yearly updates to the regulatory authorities and status updates
• Responsible for communication and escalation of study related issues to the COPL
• Provides enrollment forecasting to internal stakeholder, such as Clinical Supply, at agreed upon frequency
• Conducts routine completeness checks of the Trial Master File (TMF) to ensure compliance with ICH/GCP and company SOPs as well as ensuring all appropriate documents are filed
• Participates and responds to Quality Assurance and/or regulatory authority inspection audits
• In conjunction with CRO and appropriate internal stakeholders, facilitates the development of trial budgets and execution of clinical trial agreements and other relevant documents
• Manages the clinical trial budget and provides financial reporting and projections to Finance
• Leads creation of scope of work and budgets and escalates vendor performance issues to COPL and Procurement as necessary
• Participates in operational improvement initiatives (e.g., SOP development, training, etc.)
More about You
Desired Education and Skills:
• Experience in management of CROs, vendors and consultants
• Documented training, knowledge, and application of current FDA/EU Regulations, GCP and ICH guidelines for patient registries and studies
• Experience developing trial plans including site management, risk mitigation strategies, trial budgets and program-level budgets
• Proficient written and verbal communication skills
• Ability to collaborate effectively with the study team, cross-functional team members and external partners (including investigator and site staff) using collaborative negotiation skills
• Strong computer skills including knowledge of Excel, Word, PowerPoint, Outlook and MS Project
• Position may require some travel
• Bachelor's degree in health sciences or related field
• Minimum of 7+ years' experience in clinical research with at least 4 years' experience in study management with strong experience with study phases I-IV, global trials, and with complex trial designs. Rare disease study management is recommended.
What Now?
We're always looking for solution-oriented, critical thinkers.
So, if you're comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
#LI-Onsite
This position requires work on site at one of Sarepta's facilities in the United States.
The targeted salary range for this position is $152,400 - $190,500 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta's compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.
Candidates must be authorized to work in the U.S.
Sarepta Therapeutics offers a competitive compensation and benefit package.
Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.

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