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Antibody Discovery Jobs (NOW HIRING)

BigHat Biosciences

Director, Antibody Discovery

San Mateo, CA · On-site

$220K - $250K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

This individual will lead the company's antibody discovery and display function. They will be responsible for conceiving of and leading multi-year team and technology strategy as well as managing ...

BigHat Biosciences

Director, Antibody Discovery

San Mateo, CA · On-site

$220K - $250K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

Director, Antibody Discovery Department: Lab Science Employment Type: Full Time Location: San Mateo, CA Description The Role: BigHat is seeking an exceptional and highly experienced individual for a ...

BigHat Biosciences

Director, Antibody Discovery

San Mateo, CA

$220K - $250K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

This individual will lead the company's antibody discovery and display function. They will be responsible for conceiving of and leading multi-year team and technology strategy as well as managing ...

MSD

Senior Scientist, Antibody Discovery

South San Francisco, CA

$110K - $150K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Design, execute, and lead antibody discovery campaigns using single B-cell discovery workflows. * Identify and implement opportunities to reduce timelines, improve throughput, and increase ...

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Antibody Discovery information

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$46K

$81.7K

$131.5K

How much do antibody discovery jobs pay per year?

As of Aug 17, 2026, the average yearly pay for antibody discovery in the United States is $81,704.00, according to ZipRecruiter salary data. Most workers in this role earn between $62,500.00 and $92,000.00 per year, depending on experience, location, and employer.

What is an antibody discovery?

An Antibody Discovery job involves identifying and developing new therapeutic antibodies for medical applications, such as disease treatment or diagnostics. Scientists in this role use techniques like hybridoma technology, phage display, and single B-cell screening to discover novel antibodies. They collaborate with immunologists, molecular biologists, and bioinformaticians to optimize antibody properties like specificity and affinity. This role is critical in biotechnology and pharmaceutical industries, contributing to drug development and precision medicine.

What does an antibody discovery do?

In an Antibody Discovery position, you can expect to design and conduct experiments to identify and optimize novel antibodies, analyze large datasets, and troubleshoot protocols. Your daily work often involves hands-on laboratory research, documenting results, and regularly discussing findings with project teams and cross-functional colleagues such as bioinformaticians and protein engineers. Collaboration is key, as many projects require coordination across different scientific disciplines. Additionally, you may present research updates, contribute to patent applications, and keep abreast of new technologies in antibody engineering. This dynamic environment offers continuous learning and professional growth for scientists passionate about therapeutic innovation.

What are the key skills and qualifications needed to thrive in antibody discovery?

To excel in Antibody Discovery, a strong background in molecular biology, immunology, and protein engineering—often supported by an advanced degree (MSc or PhD)—is essential. Experience with lab techniques such as phage display, flow cytometry, and bioinformatics analysis software is commonly required, along with familiarity with data management systems. Strong analytical thinking, attention to detail, communication, and teamwork skills are highly valued in this role. These skills ensure precise experimental results, effective collaboration, and innovation in developing novel therapeutic antibodies.

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Antibody Discovery jobs near you
Infographic showing various Antibody Discovery job openings in the United States as of August 2026, with employment types broken down into 1% Internship, 88% Full Time, 9% Part Time, and 2% Contract. Highlights an 82% Physical, 5% Hybrid, and 13% Remote job distribution, with an average salary of $81,704 per year, or $39.3 per hour.

Director, Antibody Discovery

BigHat Biosciences

San Mateo, CA • On-site

$220K - $250K/yr

Full-time

Medical, Dental, Vision, Retirement

Posted 10 days ago

Job description

Description
The Role: BigHat is seeking an exceptional and highly experienced individual for a position as Director of Antibody Discovery. This individual will lead the company’s antibody discovery and display function. They will be responsible for conceiving of and leading multi-year team and technology strategy as well as managing routine operational execution for identification and maturation of high-quality antibodies across antigen types for both BigHat and BigHat-partnered therapeutic research programs.

Key Responsibilities
  • Lead BigHat’s antibody discovery and display functions, setting the scientific, technical, and strategic direction 
  • Oversee the routine execution of display-based selection campaigns to enhance and diversify affinity, developability, and function across diverse antibody formats and antigen types in support of BigHat and BigHat-partnered therapeutic programs
  • Manage and mentor a team of scientists responsible for antibody library design, generation, screening, selection, and early optimization
  • Shape and expand BigHat’s antibody discovery technologies and capabilities, including new display and selection methods, library design strategies, and technical approaches that leverage and enhance the company’s integrated experimental and computational platform
  • Provide scientific leadership across discovery and early optimization efforts, ensuring antibodies emerging from selections possess strong functional and developability characteristics
  • Work closely with leaders in Protein Sciences, Data Science/Machine Learning, Engineering, and Platform groups to ensure seamless progression from discovery through characterization and optimization
  • Collaborate with biology and therapeutic research leads to ensure display outputs align with and advance program objectives
  • Foster a collaborative and high-performance culture within the discovery organization

Skills Knowledge and Expertise
  • Ph.D. in molecular biology, biochemistry, protein engineering, or related discipline with 10+ years of experience in antibody discovery and engineering within academia, biotechnology, or pharmaceutical industries
  • 5+ years of managerial experience leading scientific teams
  • Strong expertise with protein display systems such as yeast, phage, mammalian, or mRNA display
  • Demonstrated experience with antibody library design, construction, screening, and selection analysis
  • Deep understanding of antibody structure-function relationships and mechanisms of antigen recognition
  • Experience integrating antibody discovery workflows with downstream characterization and developability assessment, including functional screening and biophysical evaluation of antibody candidates
  • Familiarity with computational or ML-enabled approaches to protein design and optimization
  • Experience advancing biologics from early discovery through lead optimization stages
  • Knowledge of diverse antibody modalities including multispecific antibodies, antibody fragments, and other advanced formats
  • Strong leadership skills with experience building and mentoring scientific teams
  • Strategic thinker capable of aligning discovery activities with broader company goals
  • Excellent communication and cross-functional collaboration skills
  • Self-motivated and comfortable working in a fast-paced startup environment
  • Must be willing to work onsite 5 days per week

Total Rewards
The salary estimated for this position is $220,000 - $250,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
What BigHat Offers:
  • Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
  • Dental, and vision coverage through Guardian
  • Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
  • 401(k) with company match 
  • DTO, two weeks of company-wide shutdown, and 12 company holidays
  • Paid parental leave