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Associate Scientist, Protein Sciences

San Jose, CA · On-site

$115K - $125K/yr

Perform purification using AKTA/HPLC systems and maintain equipment. * Conduct antibody characterization of antibodies including binding affinity and binding kinetics through Octet/Biacore, epitope ...

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How much do antibody purification jobs pay per year?

As of Aug 6, 2026, the average yearly pay for antibody purification in the United States is $211,935.00, according to ZipRecruiter salary data. Most workers in this role earn between $205,000.00 and $220,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in antibody purification?

To thrive in Antibody Purification, you need a solid background in biochemistry or molecular biology, laboratory experience, and often a relevant degree. Familiarity with chromatography systems (such as FPLC or HPLC), centrifugation, and protein quantification assays, as well as knowledge of GMP/GLP standards, is typically required. Attention to detail, problem-solving skills, and strong teamwork abilities distinguish top performers in this field. These skills and qualities ensure the accuracy, efficiency, and reproducibility of antibody production processes critical for research and therapeutic applications.

What is antibody purification?

Antibody purification is the process of isolating antibodies from complex biological mixtures such as blood serum, cell culture supernatants, or ascites fluid. This process typically involves techniques like affinity chromatography, protein A/G purification, or ion exchange chromatography to obtain highly pure antibodies for research, diagnostic, or therapeutic use. The goal is to remove contaminants and concentrate the antibody for downstream applications such as immunoassays, western blotting, or therapeutic development.

What are some common challenges faced in antibody purification roles, and how can they be addressed?

Professionals in antibody purification often encounter challenges such as ensuring high yield and purity, managing variability in sample quality, and troubleshooting equipment or process issues. Overcoming these challenges typically involves careful optimization of purification protocols, regular calibration and maintenance of chromatography systems, and close collaboration with upstream and downstream teams. Staying updated on the latest purification technologies and best practices can also help address these issues effectively, leading to more consistent and reliable results.
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Antibody Purification jobs near you
Infographic showing various Antibody Purification job openings in the United States as of August 2026, with employment types broken down into 65% Full Time, 30% Part Time, 1% Temporary, and 4% Contract. Highlights an 91% Physical, 1% Hybrid, and 8% Remote job distribution, with an average salary of $211,935 per year, or $101.9 per hour.

Supervisor- Antibody Purification Manufacturing

BioLegend

San Diego, CA

Full-time

Re-posted 29 days ago

Job description

BioLegend develops world-class, cutting-edge antibodies and reagents for biomedical research, manufactured in our state-of-the-art facility in San Diego, CA. Our mission is to accelerate research and discovery by providing the highest quality products at an outstanding value, along with superior customer service and technical support. Our product expertise covers a diverse set of research areas including Immunology, Neuroscience, Cancer, Stem cells, and Cell Biology. 

Job Summary

The Purification Supervisor is responsible for managing all essential functions related to antibody purification. Candidate must have extensive knowledge of all purification processes and be capable of extensive trouble shooting. Must be able to train new employees on all purification processes, as well as ISO standards and company policies. Must be able to collaborate with other departments and create assignments, reports, and other data. Must be able to manage, coach, and develop a large department.

Essential Functions

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

  • High Level understanding of IGG and IGM antibody protein structure and purification methods, antibody fragmentation, and antibody rework methods
  • Perform basic math calculations to calculate amount of antibodies
  • Prepare Buffers according to SOPs
  • Review SDS and IEF Gel electrophoresis
  • Expert with ERP system for management and manufacturing purposes
  • Expert in bulk order preparation
  • Train new employees on all purification processes
  • Extensive knowledge with troubleshooting issues in purification processes. Prepare data for weekly meetings. Responsible for opening and closing Non-conforming reports
  • Employee performance reviews and coaching and development
  • Recruiting new employees—resume review, interviews, selection
  • Create and edit SOPs and batch records
  • Ensure that department operates under ISO guidelines—train and enforce standards. Work with QA department to be trained and have complete understanding of ISO guidelines
  • Collaborate with multiple internal departments
  • Create weekly and monthly tasks to give to employees, as well as monthly reports to the manager
  • In charge of incoming raw materials from outside vendors—collaborate with Receiving Department to properly receive and manage OEM material 

Minimum Qualifications – Education and Experience

  • BS degree in Biochemistry, Chemistry, or Science
  • 4-5 years relevant lab experience with column chromatography, gel electrophoresis (SDS-PAGE, IEF gel) or knowledge of other analytical or detection methods. Supervisory experience preferred 

Preferred Qualifications – Education and Experience 

  • Strong organizational, documentation, and interpersonal skills are essential. Must take initiative, be flexible, highly motivated, and dependable.  Good computer skills are a plus. Must be extremely detail-oriented. Great time management and multi-tasking skills

Condition of Employment

Concerns regarding COVID-19 continue as positive cases are experienced in the communities in which we operate. Please be aware that, as a condition of employment, BioLegend requires proof of COVID vaccination for all U.S.-based employees (subject to limited exceptions) beginning January 18, 2022.

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