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Astrion is a reputable company in the industry, known for its commitment to innovation and customer satisfaction. The company's workplace is characterized by a collaborative environment, where employees can engage in creative problem-solving and work together to drive progress. Joining Astrion offers opportunities for professional growth and development, as well as the chance to contribute to meaningful projects and make a lasting impact.
Infographic showing various Senior Program Manager job openings at Astrion in the United States as of August 2026, with employment types broken down into 98% Full Time, 1% Part Time, and 1% Contract. Highlights an 97% Physical, and 3% Hybrid job distribution.

Director, Program Management

Artis BioSolutions

Watertown, MA

Full-time

Re-posted 14 days ago


Job description

We are seeking an experienced, driven, and collaborative Director of Program Management to lead the execution of complex, cross-functional client programs in the development and GMP manufacturing of cell and gene therapies. This leader will be responsible for driving program success across multiple client engagements and ensuring alignment with strategic and operational goals.

This role requires deep understanding of GMP operations, program and stakeholder management, and the ability to lead both internal teams and external clients with clarity, confidence, and accountability.

Responsibilities
  • Lead and oversee multiple complex, cross-functional client programs from contract award through closure, ensuring on-time, on-budget, and on-scope delivery.
  • Own the client relationship for assigned programs; serve as the main point of contact and ensure program health, transparency, and trust with both internal and external stakeholders.
  • Develop and maintain program documentation, including charters, timelines, risk registers, change orders, budgets, meeting minutes, and stakeholder reports.
  • Drive strategic alignment between program objectives and broader business goals; contribute to long-term planning, client development, and organizational strategy.
  • Collaborate cross-functionally with Process & Analytical Development, Quality, GMP Manufacturing, Supply Chain, Facilities, Engineering, Quality Control and Regulatory to deliver program milestones.
  • Identify and manage program risks through proactive mitigation planning and structured risk management frameworks.
  • Track and report on key performance indicators (KPIs), such as delivery timelines, client satisfaction, quality metrics, and budget adherence.
  • Lead program steering committees and governance forums; prepare executive-level presentations and reports for internal and client leadership.
  • Contribute to the development of scalable PMO tools and frameworks, including Smartsheet dashboards, process maps, and templates.
  • Champion process improvements, lead root-cause analyses for program deviations, and contribute to organizational learning and maturity.
Qualifications
  • BA/BS degree in a relevant field required; advanced degree (MS, MBA, PhD) is a plus.
  • 10+ years of program or project management experience in life sciences, with at least 5 years leading cross-functional programs in GMP manufacturing of cell, gene, or biologic therapies.
  • Proven ability to lead client-facing engagements, manage complex stakeholders, and resolve cross-functional conflicts.
  • 3+ years of people management experience, including direct reports and matrixed team leadership preferred.
  • Deep understanding of GMP principles and regulated development environments.
  • PMP certification or equivalent is preferred.
  • Strong knowledge of project management tools and systems, including Smartsheet, Microsoft Project, and PowerPoint.
  • Demonstrated financial acumen, including budget tracking and change order management.
  • Experience working in a matrixed, fast-paced, and early-stage environment is a plus.

Ideal Candidate Attributes:

  • Strategic thinker with excellent execution discipline
  • Exceptional communicator and relationship builder
  • High emotional intelligence and leadership presence
  • Comfortable with ambiguity, change, and problem-solving
  • Passionate about improving human health through scientific innovation
Landmark Bio is dedicated to translating cutting-edge research into life-changing therapies. The company provides CMC development and GMP manufacturing capabilities for cell and gene therapies and other novel modalities, and partners with academic, biotech, and industry collaborators to advance next-generation manufacturing technologies.

Landmark Bio is an Equal Opportunity, Affirmative Action employer. Minorities, women, veterans, and individuals with disabilities are encouraged to apply.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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