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Molecular Biologist / Scientist Duties: • Carry out standard operating procedures involving basic laboratory techniques, operation of laboratory equipment and record keeping necessary to a research ...
$32/hr
Full-time
Re-posted 3 days ago
Title: Scientist II - Assay development and compound profiling
Rate: $32/HR
Education Requirement:
• BS/BA degree in biochemistry, biophysics or a related discipline with a minimum of 3-5 years industry experience; or a MS degree in biochemistry, biophysics or a related discipline with 2 or more years of industry experience, preferably with a focus on assay development and compound profiling within a drug discovery environment.
Required Skills:
• Candidate should have basic knowledge of biochemistry, biophysics and molecular biology
• Candidate should have prior experience with basic biochemical and/or biophysical techniques
• Candidate should be highly motivated, driven, and willing to take the initiative to learn new scientific methodologies
• Candidate should be a strong team player
• Candidate should have excellent oral and written communication skills
• Candidate should be comfortable using a PC computer and proficient in Windows-based operating systems and basic applications, such as spreadsheets and databases
• Experience in the use of automated liquid handlers such as Echo, Bravo, Biomek, or Hamilton and data analysis and presentation software such as TIBCO Spotfire, Excel and PowerPoint.
Preferred Attributes:
• Proven ability to independently design, develop and implement biochemical and biophysical screening assays using detection modalities such as: TR-FRET, FP, LC-MS, radiochemical, surface plasmon resonance (BIAcore), fluorescence-based thermal shift (TdF), and/or isothermal titration calorimetry (ITC).
• Hands-on experience performing steady-state and transient-state kinetic experiments to study enzymes and inhibitors.
• Direct experience in recombinant protein expression using bacteria, insect (baculovirus) and/or mammalian cell-based systems and purification using automated chromatographic separation systems.
Responsibilities:
This is an exciting opportunity in the Biochemistry and Biophysics Group within the Department of Pharmacology at MRL-Boston. The successful candidate is expected to:
• Develop and/or run quantitative biochemical and biophysical assays to support identification, characterization, and optimization of small molecule ligands from high throughput screening campaigns and medicinal chemistry efforts.
• Conduct biochemical and biophysical studies to elucidate the modes of ligand interaction and mechanisms of action on target proteins.
If interested; kindly share your updated resume with answers:
Q1: How many years of exp in assay development and compound profiling within a drug discovery environment.
Q2: Did you independently design, develop and implement biochemical and biophysical screening assays using detection modalities such as: TR-FRET, FP, LC-MS, radiochemical, surface plasmon resonance (BIAcore), fluorescence-based thermal shift
Q3: Did you Hands-on experience performing steady-state and transient-state kinetic experiments to study enzymes and inhibitors.
Q4: How far you live from 33 Avenue Louis Pasteur, Boston, MA and how will you commute daily
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11 - 50 Employees
Sugar Land, TX, US