Xray Crystallography Jobs (NOW HIRING)

Job Family:

Biologist

Travel Required:

None

Clearance Required:

Ability to Obtain Public Trust

What You Will Do:

We are currently seeking a Structural Biologist to support the National Institute of Allergy and Infectious Diseases (NIAID). The ideal candidate brings strong expertise in structural biology methods, independent data analysis, and effective collaboration with multidisciplinary research teams. This is a full-time, on-site opportunity in Bethesda, MD.

• Process and analyze structural datasets, including but not limited to cryo-electron microscopy (cryo-EM) and X-ray crystallography data.
• Refine structural models and interpret structural findings.
• Apply antigen design and protein engineering tools to support scientific research projects.
• Conduct structure prediction and modeling to inform experimental design.
• Perform in vitro biochemical and biophysical assays to evaluate proteins and constructs.
• Analyze experimental data and identify biologically relevant findings.
• Identify, recommend, and implement new structure-related technologies to enhance VRC capabilities.
• Develop, implement, and document standard operating procedures (SOPs) for structural prediction, protein design, and data visualization.
• Collaborate with NIH investigators and multidisciplinary project teams to support ongoing research.
• Provide scientific input and technical feedback on experimental approaches.
• Prepare structural data and models for submission to public databases (e.g., Protein Data Bank, Electron Microscopy Data Bank).
• Contribute to preparation of manuscripts, presentations, and scientific communications.
• Collaborate with visualization teams to develop graphical or 3D representations of structural data for presentations and publications.

What You Will Need:

• Ph.D. in Structural Biology, Biochemistry, Biophysics, Computational Biology, or a closely related biomedical field; OR Master's degree with a minimum of FOUR (4) years of experience in structural biology, biochemistry, biophysics, or related scientific research is equivalent to a Ph.D.
• Demonstrated expertise in structural biology techniques, including cryo-electron microscopy (cryo-EM) and/or X-ray crystallography.
• Ability to independently process cryo-EM and/or X-ray crystallography datasets, refine structures, and interpret results.
• Experience applying antigen design and protein engineering tools.
• Experience developing and implementing advanced structural biology methods and protocols.
• Strong collaboration, communication, and organizational skills to support multidisciplinary teams.
• Proficiency with Microsoft Office Suite and scientific data tools.
• Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

What Would Be Nice To Have:

• Background working with viral glycoproteins and related structural analysis.
• Exposure to vaccine or infectious disease research programs.
• Familiarity with preparing and submitting data to public repositories such as PDB or EMDB.
• Ability to collaborate with visualization or computational modeling teams.

The annual salary range for this position is $85,000.00-$141,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance

• Personal and Family Sick Time & Company Paid Holidays

• Parental Leave

• 401(k) Retirement Plan

• Group Term Life and Travel Assistance

• Voluntary Life and AD&D Insurance

• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

• Transit and Parking Commuter Benefits

• Short-Term & Long-Term Disability

• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

• Employee Referral Program

• Corporate Sponsored Events & Community Outreach

• Care.com annual membership

• Employee Assistance Program

• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer-Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

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