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Upstream Scientist Fermentation Jobs (NOW HIRING)

Archer Daniels Midland

Communicate with upstream and downstream scientists to understand their constraints and provide ... Document fermentation run plan, log sheet, and summary in an electronic lab notebook * Contribute ...

Iff

Senior Scientist I

Union, SC · On-site

$97K - $139K/yr

Drive the development of sustainable flavor ingredients through microbial fermentation ... Design and execute laboratory-scale upstream process development programs to support new ingredient ...

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International Flavors & Fragrances Inc.

$97K - $139K/yr

... fermentation, biocatalysis, and natural product discovery ... Design and execute laboratory-scale upstream process development programs to support new ingredient ...

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Scientist II, Upstream Development for Protein Development and Manufacturing

San Carlos, CA

Vaxcyte
Biotechnology Research and Development • 51 - 200 employees
Learn more about Vaxcyteexternal

$146K - $171K/yr

Full-time

Re-posted 13 days ago

Key responsibilities

  • Contribute to the development and characterization of upstream fermentation processes.

  • Serve as a primary technical contributor to bioreactor setup, monitoring, harvest, and maintenance activities.

  • Develop, test, and implement recipe scripting for fed-batch fermentation feeding controls.

Job description

Summary:

Vaxcyte is seeking a talented and experienced Scientist II, to join the Upstream Process Development group within the Protein Development and CMC team. This is an exciting opportunity to join an outstanding team pursuing bacterial fermentation development at Vaxcyte.

The successful candidate will have the following skills and qualities:

  • A skilled upstream scientist with expertise in developing and characterizing bacterial fermentation processes for protein production.
  • Hands-on experience operating and maintaining bioreactors, including Ambr 250, at laboratory scale.
  • Experience with pilot scale fermentation and recovery equipment is a plus.
  • Skillful in analyzing and presenting data for process improvements, troubleshooting, and optimization.
  • An exceptional team player who works seamlessly with others, speaks up, and remains focused on achieving the best results to achieve company goals.
  • An experienced scientist who works with growing independence, collaborates across functional teams, and mentors junior colleagues.
  • Strong organizational and planning skills.
Essential Functions:
  • Contribute significantly to the development and characterization of upstream fermentation processes.
  • Serve as a primary technical contributor to operational activities related to bioreactor set-up, monitoring, harvest, and maintenance.
  • Develop, test, and implement recipe scripting for fed-batch fermentation feeding controls.
  • Provide engineering support for design, implementation, and qualification of scale-down models.
  • Author SOPs (standard operating procedure), process flow diagrams and batch records.
  • Analyze and present fermentation data at internal project meetings. Participate in upstream database management and documentation in electronic notebooks.
  • Collaborate with Downstream Process Development, Pilot Plant, MSAT, or Analytical Development as needed.
  • Provide guidance or mentorship to junior team members.
Requirements: 
  • PhD with 2-5 years, MS with 7 years, or BA/BS with a minimum of 10 years of relevant Pharma/Biotech industry experience. Other combinations of education and/or experience may be considered.
  • Strong scientific background and hands-on experience with fermentation and/or primary recovery unit operations.
  • Good understanding in fundamentals of bioreactor design, operation and controls.
  • Strong knowledge of aseptic techniques
  • Mechanical and technical knowledge of primary recovery unit operations such as homogenization, centrifugation, and depth filtration, is a plus
  • Understanding of fermentation scale up and development of scale down models
  • Familiarity with DoE (Design of Experiments) principles and software.
  • Familiarity with regulatory requirements of biotherapeutics. Late-stage process characterization experience is a plus.
Reports to: Senior Scientist, Upstream Development and Manufacturing
 
Location: San Carlos, CA
 
Work Arrangement (may be adjusted based on business needs, job responsibilities, or changes to company policy): 
Onsite (5 days per week onsite)
 
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
 
Salary Range: $146,000 - $171,000
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About Vaxcyte

Sourced by ZipRecruiter

Industry

Biotechnology research and development

Company size

51 - 200 Employees

Headquarters location

San Carlos, CA, US

Year founded

2013

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