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Upstream Engineering Jobs in Raleigh, NC (NOW HIRING)

Valspec

Process Validation Engineer

Raleigh, NC

$70 - $80/hr

... engineering support to production and startup activities across Drug Substance manufacturing, with a primary focus in one of the following areas depending on team assignment: Upstream (cell culture ...

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Upstream Engineering information

See Raleigh, NC salary details

$31.6K

$61.2K

$92.8K

How much do upstream engineering jobs pay per year?

As of Aug 17, 2026, the average yearly pay for upstream engineering in Raleigh, NC is $61,219.00, according to ZipRecruiter salary data. Most workers in this role earn between $45,700.00 and $70,000.00 per year, depending on experience, location, and employer.

What is upstream engineering?

Upstream engineering refers to the branch of engineering focused on the exploration and production of oil and natural gas. It involves locating oil and gas reserves, drilling wells, and designing the extraction processes needed to bring these resources to the surface. Upstream engineers work with geologists, drillers, and other professionals to ensure efficient and safe operations. This field is critical to the energy industry and requires expertise in geology, reservoir engineering, and drilling technologies.

What are the key skills and qualifications needed to thrive as an upstream engineer, and why are they important?

To thrive as an Upstream Engineer, you need a solid background in petroleum engineering, geoscience, or a related field, often supported by a relevant degree and industry certifications. Familiarity with reservoir modeling software, drilling technologies, and data analysis tools such as Petrel, Eclipse, or Python is typically required. Strong problem-solving skills, teamwork, and effective communication are essential soft skills in this role. These competencies are vital for optimizing resource extraction, ensuring operational safety, and maximizing project efficiency in the oil and gas industry.

What are some common challenges faced by upstream engineers when working on oil and gas exploration projects?

Upstream engineers often encounter challenges such as unpredictable geological formations, fluctuating commodity prices, and logistical complexities in remote locations. They must collaborate closely with geologists, drilling teams, and field personnel to adapt to changing conditions and ensure safe, efficient extraction. Managing project timelines while adhering to environmental and safety regulations is also a significant aspect of the role. Overcoming these challenges requires strong problem-solving skills, adaptability, and effective communication across multidisciplinary teams.

What is the difference between Upstream Engineering vs Reservoir Engineering?

AspectUpstream EngineeringReservoir Engineering
Required CredentialsBachelor's in Petroleum Engineering or related field; often requires professional engineering licenseBachelor's in Petroleum Engineering, Reservoir Engineering, or Geosciences; often requires similar certifications
Work EnvironmentField operations, drilling sites, and production facilitiesReservoir simulation labs, office-based analysis, and field data interpretation
Industry UsageExploration, drilling, and production of oil and gasReservoir performance analysis and recovery optimization

Upstream Engineering focuses on the exploration, drilling, and production of oil and gas, involving field operations and equipment. Reservoir Engineering specializes in analyzing subsurface reservoirs to maximize hydrocarbon recovery through simulation and modeling. While both roles require similar educational backgrounds and certifications, their work environments and primary responsibilities differ significantly.

What are common upstream engineering jobs?

Common upstream engineering jobs include roles such as reservoir engineers, drilling engineers, production engineers, and facilities engineers. These positions focus on exploration, drilling, extraction, and production of oil and gas, often requiring knowledge of geology, reservoir management, and the use of specialized software and tools.

What does an upstream engineer do?

An upstream engineer is responsible for exploring, developing, and producing oil and gas resources from underground reservoirs. They design and oversee drilling operations, manage reservoir performance, and ensure safety and efficiency using tools like seismic imaging and reservoir modeling. The role often requires technical skills, knowledge of industry regulations, and experience with specialized software.

What are popular job titles related to Upstream Engineering jobs in Raleigh, NC?

For Upstream Engineering jobs in Raleigh, NC, the most frequently searched job titles are:

What job categories do people searching Upstream Engineering jobs in Raleigh, NC look for?

The top searched job categories for Upstream Engineering jobs in Raleigh, NC are:

Upstream Engineering jobs near you
Infographic showing various Upstream Engineering job openings in Raleigh, NC as of August 2026, with employment types broken down into 86% Full Time, 9% Part Time, 4% Contract, and 1% Nights. Highlights an 85% Physical, 5% Hybrid, and 10% Remote job distribution, with an average salary of $61,219 per year, or $29.4 per hour.

Specialist Manufacturing - Process Owner - Upstream / Downstream / Services

Amgen, Inc.

Holly Springs, NC • On-site

$63K - $84K/yr

Full-time

Re-posted 7 days ago

Job description

Career Category
Manufacturing
Job Description
HOW MIGHT YOU DEFY IMAGINATION?
You've worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience, and passion to work toward your goals? At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.
Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the Amgen FleX Batch facility will combine the latest in disposable technologies with traditional stainless-steel equipment to allow for maximum flexibility in operations. The FleX Batch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.
Specialist Manufacturing - Process Owner - Upstream / Downstream / Services (Multiple Positions)
Live
What You Will Do
In this vital role, you will serve as a Process Owner within the Manufacturing Support organization at Amgen North Carolina (ANC). The Process Owner serves as a technical process steward and key interface between Manufacturing Operations and support organizations. This role is responsible for supporting manufacturing execution through technical process ownership, floor support, operational readiness activities, process governance, manufacturing change implementation support, and continuous improvement initiatives.
This position may support one of the following manufacturing areas depending on business needs and organizational assignment: Upstream Manufacturing, Downstream Manufacturing, or Manufacturing Services (Raw Material Dispensing and Solution Preparation).
  • Serve as the technical process owner for assigned manufacturing processes, equipment, and unit operations.

  • Provide manufacturing floor support, troubleshooting assistance, and hypercare during routine manufacturing operations, process changes, startup activities, and first-time executions.

  • Support operational readiness activities including water runs, dry runs, equipment readiness verification, and Electronic Batch Record (EBR) testing support.

  • Partner with Manufacturing Operations to support reliable, compliant, and efficient manufacturing execution.

  • Monitor process performance and identify opportunities for process optimization, operational improvement, and risk reduction.

  • Support manufacturing-related change controls associated with process, equipment, procedural, and operational improvements.

  • Author, revise, review, and maintain manufacturing SOPs, forms, and other GMP documentation.

  • Ensure manufacturing processes are effectively translated into SOPs, manufacturing workflows, training materials, and associated digital manufacturing processes.

  • Provide technical input to manufacturing risk assessments and support identification and mitigation of process, equipment, procedural, and operational risks.

  • Participate in root cause analysis (RCA) activities and provide technical process expertise to support manufacturing investigations, major deviations, and quality events.

  • Support CAPA applicability assessments, CAPA implementation activities, and CAPA effectiveness checks.

  • Partner with Process Development to support process overviews, knowledge transfer activities, and facility fit assessments.

  • Partner with Supply Chain, Manufacturing, and Engineering to support material readiness and Bill of Material (BOM) alignment, including single-use assemblies and consumables.

  • Support MES and EBR activities by providing process expertise and manufacturing representation.

  • Participate in inspection readiness activities and support audits as required.

  • Appropriately escalate process, operational, quality, and compliance concerns.

Win
What We Expect of You
Basic Qualifications
  • Doctorate degree and 2 years of biotechnology operations experience OR

  • Master's degree in Engineering, Biology, Chemistry, Biochemistry, or related field and 4 years of biotechnology operations experience OR

  • Bachelor's degree and 6 years of biotechnology operations experience OR

  • Associate's degree and 10 years of biotechnology operations experience OR

  • High school diploma / GED and 12 years of biotechnology operations experience

Preferred Qualifications
  • Technical expertise in Upstream Manufacturing, Downstream Manufacturing, or Manufacturing Services (Raw Material Dispensing and Solution Preparation).

  • Strong technical knowledge of drug substance manufacturing processes, equipment, and unit operations.

  • Experience supporting GMP manufacturing operations in a biotechnology or pharmaceutical environment.

  • Experience supporting manufacturing floor operations, troubleshooting, and hypercare activities.

  • Experience supporting operational readiness activities including water runs, dry runs, equipment testing, and startup support.

  • Experience authoring and maintaining GMP documentation including SOPs and manufacturing procedures.

  • Experience supporting manufacturing change controls and implementation activities.

  • Experience participating in risk assessments, root cause analyses, investigations, and CAPA implementation activities.

  • Experience supporting CAPA applicability assessments and effectiveness checks.

  • Experience supporting Manufacturing Execution Systems (MES) and Electronic Batch Records (EBRs) within a GMP manufacturing environment.

  • Knowledge of single-use technologies and Bill of Material (BOM) structures.

  • Strong technical writing, communication, problem-solving, and organizational skills.

Thrive
As we work to develop treatments that take care of others, we also work to care for our teammates' professional and personal growth and well-being through comprehensive benefits, career development opportunities, and a collaborative culture.
Salary Range
107,545.40USD -145,502.60 USD

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