Upstream Principal Engineer Responsibilities:Upstream System Leadership * Serve as the ... Gain a thorough understanding of system design by reviewing engineering documentation, P&IDs, and ...
Upstream Principal Engineer Responsibilities:Upstream System Leadership * Serve as the ... Gain a thorough understanding of system design by reviewing engineering documentation, P&IDs, and ...
Upstream Principal Engineer Responsibilities:Upstream System Leadership * Serve as the ... Ensure alignment with quality, automation, and engineering teams on critical parameters and ...
Quick apply
Upstream Principal Engineer Responsibilities:Upstream System Leadership * Serve as the ... Ensure alignment with quality, automation, and engineering teams on critical parameters and ...
6242 - Upstream Principal Engineer / Lead Validation Engineer
Holly Springs, NC · On-site
$107K - $168K/yr
Upstream Principal Engineer Responsibilities: Upstream System Leadership * Serve as the ... Ensure alignment with quality, automation, and engineering teams on critical parameters and ...
6242 - Upstream Principal Engineer / Lead Validation Engineer
Holly Springs, NC · On-site
$107K - $168K/yr
Upstream Principal Engineer Responsibilities: Upstream System Leadership * Serve as the ... Ensure alignment with quality, automation, and engineering teams on critical parameters and ...
Sr. Automation Engineer - Upstream/Media
Durham, NC · On-site
$108K - $201K/yr
As a Sr. Automation Engineer - Upstream/Media, you will play a critical role in supporting the ... Bachelor's degree in Engineering, Computer Science, or a related technical discipline. * 8+ years ...
New
Sr. Automation Engineer - Upstream/Media
Durham, NC · On-site
$108K - $201K/yr
As a Sr. Automation Engineer - Upstream/Media, you will play a critical role in supporting the ... Bachelor's degree in Engineering, Computer Science, or a related technical discipline. * 8+ years ...
New
Sr. Automation Engineer - Upstream/Media
Durham, NC · On-site
$108K - $201K/yr
As a Sr. Automation Engineer - Upstream/Media, you will play a critical role in supporting the ... Bachelor's degree in Engineering, Computer Science, or a related technical discipline. * 8+ years ...
New
Sr. Automation Engineer - Upstream/Media
Durham, NC · On-site
$108K - $201K/yr
As a Sr. Automation Engineer - Upstream/Media, you will play a critical role in supporting the ... Bachelor's degree in Engineering, Computer Science, or a related technical discipline. * 8+ years ...
New
Our proprietary vector engineering approach combines novel regulatory elements and payloads with ... upstream, downstream, fill finish, and drug device * Facilitate Encoded's technology transfer of ...
New
Our proprietary vector engineering approach combines novel regulatory elements and payloads with ... upstream, downstream, fill finish, and drug device * Facilitate Encoded's technology transfer of ...
New
Sr. Automation Engineer - Upstream/Media
$108K - $201K/yr
As a Sr. Automation Engineer - Upstream/Media, you will play a critical role in supporting the ... Bachelor's degree in Engineering, Computer Science, or a related technical discipline. * 8+ years ...
New
Sr. Automation Engineer - Upstream/Media
$108K - $201K/yr
As a Sr. Automation Engineer - Upstream/Media, you will play a critical role in supporting the ... Bachelor's degree in Engineering, Computer Science, or a related technical discipline. * 8+ years ...
New
Senior Process Engineer - Solution Prep, Upstream, and Downstream
Holly Springs, NC · On-site
$90K - $116K/yr
Senior Process Engineer - Solution Prep, Upstream and Downstream What you will do * Support the ... Perform engineering assessments for plant equipment operations, implementing equipment ...
Senior Process Engineer - Solution Prep, Upstream, and Downstream
Holly Springs, NC · On-site
$90K - $116K/yr
Senior Process Engineer - Solution Prep, Upstream and Downstream What you will do * Support the ... Perform engineering assessments for plant equipment operations, implementing equipment ...
CQV Lead, Upstream
Holly Springs, NC · On-site
$88K - $116K/yr
Title - CQV Lead, Upstream Location: Holly Springs, North Carolina Visa - OPEN NEED LEAD CANDIDATE ONLY WITH LINKEDIN PROFILE seeking a highly experienced CQV (Commissioning, Qualification, and ...
Quick apply
CQV Lead, Upstream
Holly Springs, NC · On-site
$88K - $116K/yr
Title - CQV Lead, Upstream Location: Holly Springs, North Carolina Visa - OPEN NEED LEAD CANDIDATE ONLY WITH LINKEDIN PROFILE seeking a highly experienced CQV (Commissioning, Qualification, and ...
Career Category Engineering Join Amgen's Mission of Serving Patients At Amgen, if you feel like you ... Process Engineer - Solution Prep, Upstream, and Downstream What you will do In this vital role you ...
Career Category Engineering Join Amgen's Mission of Serving Patients At Amgen, if you feel like you ... Process Engineer - Solution Prep, Upstream, and Downstream What you will do In this vital role you ...
Staff will work cross-functionally with QA, MS&T, facilities, engineering, supply chain, IT, AFS ... Basic knowledge of upstream (cell culture or fermentation) unit operations is preferred. Experience ...
Staff will work cross-functionally with QA, MS&T, facilities, engineering, supply chain, IT, AFS ... Basic knowledge of upstream (cell culture or fermentation) unit operations is preferred. Experience ...
Career Category Engineering Join Amgen's Mission of Serving Patients At Amgen, if you feel like you ... Principal Process Engineer - Upstream/Downstream What you will do In this vital role you will be ...
Career Category Engineering Join Amgen's Mission of Serving Patients At Amgen, if you feel like you ... Principal Process Engineer - Upstream/Downstream What you will do In this vital role you will be ...
PrincipalProcess Engineer- Upstream/Downstream What you will do In this vital role you will be ... You will solve complex engineering problems, optimize processes, and ensure the company ...
New
PrincipalProcess Engineer- Upstream/Downstream What you will do In this vital role you will be ... You will solve complex engineering problems, optimize processes, and ensure the company ...
New
Staff will work cross-functionally with QA, MS&T, facilities, engineering, supply chain, IT, AFS ... Basic knowledge of upstream (cell culture or fermentation) unit operations is preferred. Experience ...
Staff will work cross-functionally with QA, MS&T, facilities, engineering, supply chain, IT, AFS ... Basic knowledge of upstream (cell culture or fermentation) unit operations is preferred. Experience ...
Career Category Engineering Join Amgen's Mission of Serving Patients At Amgen, if you feel like you ... ProcessEngineer-Solution Prep,Upstream, andDownstream What youwill do In this vital role you will ...
Career Category Engineering Join Amgen's Mission of Serving Patients At Amgen, if you feel like you ... ProcessEngineer-Solution Prep,Upstream, andDownstream What youwill do In this vital role you will ...
Career Category Engineering Join Amgen's Mission of Serving Patients At Amgen, if you feel like you ... Principal Process Engineer - Upstream/Downstream What you will do In this vital role you will be ...
Career Category Engineering Join Amgen's Mission of Serving Patients At Amgen, if you feel like you ... Principal Process Engineer - Upstream/Downstream What you will do In this vital role you will be ...
Senior Process Engineer - Solution Prep, Upstream, and Downstream
Holly Springs, NC · On-site
$90K - $116K/yr
Career Category Engineering Join Amgen's Mission of Serving Patients At Amgen, if you feel like you ... SeniorProcessEngineer-Solution Prep,Upstream,andDownstream What youwill do In this vital role you ...
Senior Process Engineer - Solution Prep, Upstream, and Downstream
Holly Springs, NC · On-site
$90K - $116K/yr
Career Category Engineering Join Amgen's Mission of Serving Patients At Amgen, if you feel like you ... SeniorProcessEngineer-Solution Prep,Upstream,andDownstream What youwill do In this vital role you ...
Senior Process Engineer - Solution Prep, Upstream, and Downstream
Holly Springs, NC · On-site
$90K - $116K/yr
Career Category Engineering Join Amgen's Mission of Serving Patients At Amgen, if you feel like you ... Senior Process Engineer - Solution Prep, Upstream, and Downstream What you will do In this vital ...
Senior Process Engineer - Solution Prep, Upstream, and Downstream
Holly Springs, NC · On-site
$90K - $116K/yr
Career Category Engineering Join Amgen's Mission of Serving Patients At Amgen, if you feel like you ... Senior Process Engineer - Solution Prep, Upstream, and Downstream What you will do In this vital ...
Our proprietary vector engineering approach combines novel regulatory elements and payloads with ... upstream, downstream, fill finish, and drug device * Facilitate Encoded's technology transfer of ...
Our proprietary vector engineering approach combines novel regulatory elements and payloads with ... upstream, downstream, fill finish, and drug device * Facilitate Encoded's technology transfer of ...
Our proprietary vector engineering approach combines novel regulatory elements and payloads with ... upstream, downstream, fill finish, and drug device * Facilitate Encoded's technology transfer of ...
Quick apply
Our proprietary vector engineering approach combines novel regulatory elements and payloads with ... upstream, downstream, fill finish, and drug device * Facilitate Encoded's technology transfer of ...
Upstream Engineering information
See Raleigh, NC salary details
$31.6K - $37.2K
9% of jobs
$37.2K - $42.7K
6% of jobs
$46.8K is the 25th percentile. Wages below this are outliers.
$42.7K - $48.3K
14% of jobs
$48.3K - $53.9K
10% of jobs
The median wage is $59.4K / yr.
$53.9K - $59.4K
12% of jobs
$59.4K - $65K
9% of jobs
$69.3K is the 75th percentile. Wages above this are outliers.
$65K - $70.6K
21% of jobs
$70.6K - $76.1K
5% of jobs
$76.1K - $81.7K
6% of jobs
$81.7K - $87.3K
4% of jobs
$87.3K - $92.8K
4% of jobs
$31.6K
$61.2K
$92.8K
How much do upstream engineering jobs pay per year?
What is upstream engineering?
What are the key skills and qualifications needed to thrive as an upstream engineer, and why are they important?
What are some common challenges faced by upstream engineers when working on oil and gas exploration projects?
What is the difference between Upstream Engineering vs Reservoir Engineering?
| Aspect | Upstream Engineering | Reservoir Engineering |
|---|---|---|
| Required Credentials | Bachelor's in Petroleum Engineering or related field; often requires professional engineering license | Bachelor's in Petroleum Engineering, Reservoir Engineering, or Geosciences; often requires similar certifications |
| Work Environment | Field operations, drilling sites, and production facilities | Reservoir simulation labs, office-based analysis, and field data interpretation |
| Industry Usage | Exploration, drilling, and production of oil and gas | Reservoir performance analysis and recovery optimization |
Upstream Engineering focuses on the exploration, drilling, and production of oil and gas, involving field operations and equipment. Reservoir Engineering specializes in analyzing subsurface reservoirs to maximize hydrocarbon recovery through simulation and modeling. While both roles require similar educational backgrounds and certifications, their work environments and primary responsibilities differ significantly.
What are popular job titles related to Upstream Engineering jobs in Raleigh, NC?
For Upstream Engineering jobs in Raleigh, NC, the most frequently searched job titles are:
What job categories do people searching Upstream Engineering jobs in Raleigh, NC look for?
The top searched job categories for Upstream Engineering jobs in Raleigh, NC are:
- Industrial Engineering Intern
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- Internship Nuclear Engineering Internships
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- Internship Microsoft Biomedical Engineering
- Intern Computational Materials Science
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- Engineering Intern

6242 - Upstream Principal Engineer / Lead Validation Engineer
Holly Springs, NC • On-site
Full-time
Re-posted 9 days ago
Job description
We are seeking an Upstream Principal Engineer is responsible for overseeing the commissioning and qualification of Upstream systems. This role ensures that all systems are designed, tested, and documented in alignment with project requirements and safety standards.
Upstream Principal Engineer Responsibilities:Upstream System Leadership- Serve as the commissioning and qualification lead for Upstream systems (responsibilities described below).
- Specific experience with chromatography systems, TFF filtration systems, viral filtration systems, and UFDF filtration systems.
- Gain a thorough understanding of system design by reviewing engineering documentation, P&IDs, and design specifications.
- Develop User Requirement Specifications (URS) and Quality Risk Assessment for Equipment and Automated Systems (QRAES).
- Engage with design engineers and SMEs to clarify system intent and operational requirements.
- Ensure alignment with quality, automation, and engineering teams on critical parameters and documentation.
- Create Commissioning Test Plans that translate design intent into testable steps.
- Coordinate with the Automation Team to incorporate all automation functional testing.
- Collaborate with SMEs to ensure system requirements are accurately reflected in test plans.
- Develop Installation, Operational, and Qualification (IOQ) protocols.
- Prepare and submit summary reports documenting commissioning and qualification activities.
- Take custody of the system post-construction and maintain ownership through C&Q completion.
- Perform Lockout/Tagout (LOTO) for system safety.
- Conduct pre-startup safety checks and risk assessments.
- Prepare daily pre-task plans and verify team readiness for safe execution.
- Attend daily commissioning meetings to coordinate activities.
- Execute commissioning and IOQ protocols.
- Resolve issues arising during execution.
- Participate in Factory Acceptance Tests (FATs) and Site Acceptance Tests (SATs) as required.
- Bachelor's degree in Engineering, Life Sciences, Biotechnology, or related technical discipline
- 10+ years of role specific experience
- Experience supporting CQV activities in GMP-regulated pharmaceutical or biotechnology environments
- Hands-on experience with downstream bioprocess equipment and purification systems
- Strong understanding of validation lifecycle documentation (IQ/OQ/PQ, protocols, reports)
- Ability to work independently while collaborating with cross-functional teams
- Strong documentation, organizational, and communication skills
- Experience with digital validation systems such as Kneat
- Experience supporting FAT/SAT, commissioning, and equipment startup
- Familiarity with risk-based validation approaches
- Experience in biologics manufacturing or monoclonal antibody production environments
- Onsite job requirement in Holly Springs, NC
About Verista
Sourced by ZipRecruiter
Industry
Pharmaceutical and medicine manufacturing
Company size
201 - 500 Employees
Headquarters location
Fishers, IN, US
Year founded
2020