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Trial Master File Manager Jobs in Florida (NOW HIRING)

... site management activities. In this position, you will ensure that assigned study sites conduct ... the Trial Master File (TMF) and the Investigator Site File (ISF). A central part of this role ...

... site management activities. In this position, you will ensure that assigned study sites conduct ... the Trial Master File (TMF) and the Investigator Site File (ISF). A central part of this role ...

... docket management software, litigation resources, and a wealth of benefits in service of ... Drafting and filing of litigation documents to include pleadings, discovery requests, discovery ...

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Trial Master File Manager information

See Florida salary details

$33.3K

$56.5K

$85.2K

How much do trial master file manager jobs pay per year?

As of Aug 14, 2026, the average yearly pay for trial master file manager in Florida is $56,483.00, according to ZipRecruiter salary data. Most workers in this role earn between $41,500.00 and $69,900.00 per year, depending on experience, location, and employer.

What are some common challenges faced by trial master file managers, and how can they be addressed?

Trial Master File Managers often encounter challenges such as ensuring TMF completeness, maintaining regulatory compliance, and coordinating document submissions across multiple stakeholders. Keeping documents up-to-date and audit-ready requires strong attention to detail and effective communication with clinical teams, vendors, and sponsors. Leveraging electronic TMF systems, implementing standardized processes, and promoting regular training can help address these challenges and ensure the integrity of the TMF throughout a study.

What is a trial master file manager?

A Trial Master File Manager is a professional responsible for overseeing the creation, maintenance, and quality control of the Trial Master File (TMF) in clinical research. The TMF is a collection of essential documents that allow the conduct of a clinical trial to be reconstructed and evaluated. The manager ensures that all documents are complete, accurate, and compliant with regulatory requirements throughout the trial's lifecycle. They work closely with clinical teams, auditors, and regulatory authorities to guarantee readiness for inspections and audits. Their role is crucial for maintaining transparency and credibility in clinical research processes.

What are the key skills and qualifications needed to thrive as a trial master file manager?

To thrive as a Trial Master File Manager, you typically need a strong background in clinical research, regulatory requirements, and document management, often supported by a degree in life sciences or a related field. Familiarity with electronic Trial Master File (eTMF) systems, GCP guidelines, and relevant industry certifications like DIA's TMF Professional Certification is important. Attention to detail, organizational skills, and effective communication help ensure TMF integrity and coordination across cross-functional teams. These skills are crucial for maintaining regulatory compliance, audit readiness, and efficient clinical trial operations.

What are the most commonly searched types of Trial Master File jobs in Florida?

The most popular types of Trial Master File jobs in Florida are:

What cities in Florida are hiring for Trial Master File Manager jobs?

Cities in Florida with the most Trial Master File Manager job openings:

Trial Operations Manager

Morgan & Morgan, P.A.

Tampa, FL • On-site

Full-time

Re-posted yesterday


Morgan & Morgan rating

6.7

Company rating: 6.7 out of 10

Based on 49 frontline employees who took The Breakroom Quiz

30th of 34 rated law firms


Job description

The Manager, Trial Operations is a senior operations role within the Trial Operations team, reporting directly to the Director of Trial Operations. The Manager owns three interconnected workstreams across the firm's regional office network: (1) Trial Partner coordination and case assignment, (2) accelerating the resolution of cases that are not trial-worthy, and (3) ensuring trial work-up compliance against firm pre-trial milestones.

This is a workstream leadership role rather than a people-management role. The Manager does not have direct reports but operates cross-functionally with Managing Partners, Trial Partners, handling attorneys, paralegal teams, and case operations staff to drive accountability, throughput, and outcomes on the firm's litigation pipeline.

Key Responsibilities

Trial Partner Coordination & Case Assignment

  • Maintain the firm's Trial Partner roster and tiering data (win rates, trial volume, recovery amounts) in coordination with the Director.
  • Recommend Trial Partner assignments for cases entering trial posture, balancing partner availability, case profile, venue, and tier-fit.
  • Track Trial Partner workload and trial calendars across regional offices; flag conflicts, capacity gaps, and reassignment needs early.
  • Serve as the central point of contact between Managing Partners, Trial Partners, and handling attorneys for assignment questions and escalations.
  • Document assignment decisions, rationales, and outcomes in Litify to build a defensible audit trail and improve future assignment quality.

Resolution of Non-Trial-Worthy Cases

  • Partner with handling attorneys and Managing Partners to identify cases in litigation that should be resolved short of trial based on liability, damages, venue, or case-specific risk factors.
  • Build and maintain a settlement pipeline view by office and attorney; report progress, aging, and stalled files to the Director on a recurring cadence.
  • Identify systemic patterns (case types, venues, vendors) where the firm is over-investing trial resources on non-trial-worthy files; recommend process changes.

Trial Work-Up Compliance

  • Own and enforce the firm's pre-trial milestone framework across regional offices, ensuring required work product is complete and timely.
  • Configure, refine, and monitor Litify milestone tasks, dashboards, and exception reports to surface non-compliance proactively.
  • Escalate compliance gaps to the Director and Managing Partners with clear root-cause analysis and remediation recommendations.
  • Lead post-trial debriefs on work-up quality; translate findings into updated checklists, templates, and process documentation.

Cross-Functional & Operational

  • Represent Trial Operations in cross-functional meetings with Managing Partners, Trial Partners, and Operation Leads.
  • Draft standardized communications (Managing Partner memos, attorney guidance, vendor outreach) on behalf of the department.
  • Contribute to the design and rollout of new Trial Operations processes, tools, and policies firm-wide.
Required Qualifications
  • Strong proficiency with case management systems (Salesforce-based platform) and Microsoft 365 (Excel, Word, Outlook, Teams).
  • Excellent written communication skills, including the ability to draft executive-level memos and structured operational reports.
  • Comfort with data: able to build, read, and act on dashboards, pivot tables, and operational metrics.
Core Competencies
  • Operational discipline - converts ambiguous goals into milestones, dashboards, and recurring cadences.
  • Judgment under pressure - distinguishes trial-worthy from non-trial-worthy cases and acts decisively.
  • Influence without authority - moves senior attorneys and Managing Partners to action through credibility, data, and clear escalation paths.
  • Process orientation - sees firm-wide patterns and converts them into repeatable systems.
  • Discretion - handles confidential case strategy, settlement posture, and personnel matters appropriately.
  • Bias for action - pushes files forward, closes loops, and refuses to let work sit.

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