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Postdoctoral positions are available to study molecular mechanisms associated with therapeutic response and resistance to RAS inhibition in non-small cell lung cancer (NSCLC) in the laboratory of Ferdinandos Skoulidis, MD, PhD, at the University of Texas MD Anderson Cancer Center in Houston, TX. The lab is largely interested in understanding the molecular diversity of KRAS-mutant NSCLC and developing rational and tailored treatment strategies for patients bearing KRAS-mutant lung tumors. We utilize a multifaceted approach that encompasses preclinical studies in immunocompetent syngeneic and genetically engineered co-mutational models of KRAS-mutant NSCLC as well as PDX/CDXs, in vitro models, and large collections of well-annotated clinical specimens.

We employ state-of-the-art computational biology/bioinformatics approaches to dissect acute and adaptive responses to RAS inhibition in vitro and in vivo. We are committed to a question-driven approach that seeks to address the most urgent clinically relevant scientific questions. Applicants with experience in any of these areas and a true passion for cutting-edge bench-to-bedside research are encouraged to apply and provide three professional references.

LEARNING OBJECTIVES Trainees will perform basic and translational research involving molecular biology approaches (such as CRISPR/Cas technology, Western blotting, ELISA, immunohistochemistry), in vitro assays (such as drug screening, flow cytometry, development of resistant cell lines) and in vivo experiments using xenograft, syngeneic and genetically engineered mouse models of KRAS-mutant lung cancer. Candidates with prior experience in computational biology will acquire additional skills and be involved in the analysis of single-cell RNA Sequencing, WES, and in situ transcriptomics data. Trainees will present their findings at regular lab meetings, departmental seminars, and national conferences.

Trainees will submit their findings for publication in a peer-reviewed scientific journal. All duties and responsibilities are carried out in compliance with institutional policies, ethical research standards, and applicable federal and state regulations. ELIGIBILITY REQUIREMENTS Applications are invited from qualified individuals interested in working in a translational research lab, with a PhD and/or MD.

The ideal candidate(s) should have less than 2 years of prior postdoctoral experience and have a background in cancer or cell and molecular biology. Experience in RAS signaling and targeting, and studies involving mouse models of KRAS-driven cancers, is preferred. We are also looking for applicants with prior expertise in computational biology and bioinformatics, including analysis of single-cell RNA sequencing data and in situ transcriptomics.

Candidates should be innovative thinkers and highly motivated to pursue an independent career in biomedical research. Job Knowledge And Skills: 1. Enthusiastic, highly self-motivated candidate with the ability to think and function independently 2.

A strong background in cancer biology or cell and molecular biology. Prior experience in RAS signaling and/or targeting is preferred 3. Expertise in computational biology/bioinformatics (including proficiency in Python/R) would be desirable, though this skill is not essential 4.

Prior experience with studies involving mice, including both xenograft/syngeneic models and genetically engineered mice, is preferred 5. Dedication to basic research, a true "drive", is important 6. Collegial nature and ability to work well as part of a team 7.

Excellent command of written and spoken English language 8. Prior publication record with at least one published manuscript as first author ADDITIONAL APPLICATION INFORMATION https://faculty.mdanderson.org/profiles/ferdinandos_skoulidis.html POSITION INFORMATION MD Anderson offers full-time postdoc positions with a salary ranging from $64,000 to $76,000. depending on the number of years of postgraduate experience

The University of Texas MD Anderson Cancer Center offers excellent benefits, including medical, dental, paid time off, retirement, tuition benefits, educational opportunities, and individual and team recognition. Offsite work arrangements are subject to approval and may be modified or revoked at any time based on business needs, performance considerations, or regulatory requirements. This position may be responsible for maintaining the security and integrity of critical infrastructure, as defined in Section 113.001(2) of the Texas Business and Commerce Code and therefore may require routine reviews and screening

The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment. It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html Apply