Staff Business Analyst Jobs (NOW HIRING)

We are seeking a highly motivated Staff Business Analyst with a strong background in genomics and oncology to join our team. You will be embedded at the front of product development for Guardant Health's clinical and genomic data applications, using your expertise in molecular diagnostics or clinical oncology to shape what gets built, how clinical data is modeled, and what it means for downstream consumers.

• Stakeholder Engagement: Collaborate with domain owners and business leaders in Real‑World Evidence, Medical Affairs, Biopharma, Product Management, and Data Engineering to gather and document business requirements, ensuring clarity of needs and objectives specific to genomic data analytics and real‑world clinical outcomes.
• Product Partnership: Operate as part of the product and engineering team, owning the problem space from early discovery through production release, shaping what gets built by driving clarity on requirements, domain and business context.
• Requirements Ownership: Own requirements end‑to‑end for clinical and genomic data products, driving conversations with domain authority, challenging assumptions, identifying gaps, and resolving ambiguity independently.
• Impact Analysis: Assess the full downstream impact when a new assay, product, biomarker, or data source is introduced, including changes to how clinical concepts are represented across the platform, data model and business logic updates, and implications for downstream consumers.
• Data Stewardship: Maintain authoritative documentation of clinical data models, business rules, data mappings, and lineage, serving as the source of truth for how clinical and genomic concepts are represented and consumed across the platform.
• User Democratization: Serve as a subject‑matter expert in oncology and genomic data workflows, providing guidance to users and stakeholders, facilitating user training, and supporting the adoption of new product features.

• 7+ years as a Business Analyst or equivalent, with the majority spent in genomics, molecular diagnostics, oncology, clinical data systems, or precision medicine.
• Deep domain experience in genomics and molecular diagnostics is required.
• Bachelor's or advanced degree in Life Sciences, Bioinformatics, Genomics, Health Informatics, or a related scientific discipline.
• Expert‑level written and verbal communication, documenting data specifications, and stakeholder communications that are clear, precise, and actionable.
• Hands‑on experience building or supporting clinical or genomic data applications, querying data, and running data analysis on analytics databases.
• Deep working knowledge of genomic data: variants, biomarkers, assay panels, clinical annotations, and translation into structured data within production systems.
• Experience in HIPAA‑compliant healthcare environments and familiarity with clinical data governance and data quality standards.
• AI & Digital Fluency: Demonstrate curiosity, sound judgment, and the ability to critically evaluate and responsibly leverage AI‑enabled tools in accordance with company policies, ethical standards, and regulatory requirements.

Hybrid work model applicable to onsite employees who are eligible. All U.S. employees living within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays, with additional in‑person days as directed by management.

Primary Location: Palo Alto, CA – Base Pay Range: $142,300 – $195,700
Other U.S. Locations – Base Pay Range: $120,955 – $166,345
If the role is performed in Colorado – Pay Range: $128,070 – $176,130

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability. All your information will be kept confidential according to EEO guidelines. To learn more about the information collected when you apply and how it is used, please review our Privacy Notice for Job Applicants.