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Senior Python Software Engineer Jobs in Indiana (NOW HIRING)

SOSi

Sr. Software Engineer

Indianapolis, IN · On-site +1

$117K - $154K/yr

SOSi is seeking an experienced Senior Software Engineer to support a mission-critical federal payroll and financial management program. This role will support software development, application ...

SOSi

Sr. Software Engineer

Indianapolis, IN · On-site

$117K - $154K/yr

SOSi is seeking an experienced Senior Software Engineer to support a mission-critical federal payroll and financial management program. This role will support software development, application ...

SOSi

Sr. Software Engineer

Indianapolis, IN · On-site +1

$117K - $154K/yr

SOSi is seeking an experienced Senior Software Engineer to support a mission-critical federal payroll and financial management program. This role will support software development, application ...

Ksmcpa

Senior Software Engineer

Indianapolis, IN · On-site

$117K - $154K/yr

We're looking for a Senior Software Engineer to focus on building the core of our applications ... Expertisein Python for backendweb developmentand dataprocessing and analysis * Strong SQL anddata ...

ModEarn

Senior Software Engineer

South Bend, IN · On-site

$120K - $158K/yr

Position Description As a Senior Software Engineer, you will be responsible for contributing to and ... Advanced knowledge of some of the following: C#, Python, Django, JSON, and/or RESTful API

ModEarn

Senior Software Engineer

South Bend, IN · On-site

$120K - $158K/yr

Position Description As a Senior Software Engineer, you will be responsible for contributing to and ... Advanced knowledge of some of the following: C#, Python, Django, JSON, and/or RESTful API

CyberMedia Technologies

Senior Software Engineer

Indianapolis, IN · On-site

$117K - $154K/yr

  • Medical

  • Retirement

  • PTO

We are currently seeking a Software Engineer (Senior) to join our team. Position Summary The Software Engineer (Senior) is responsible for conducting and/or participating in multidisciplinary ...

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Senior Python Software Engineer information

What does a senior Python software engineer do?

A Senior Python Software Engineer designs, develops, tests, and maintains complex software applications using the Python programming language. They often lead or mentor junior developers, architect software solutions, and ensure best coding practices are followed. These professionals collaborate with cross-functional teams to deliver scalable and efficient systems, troubleshoot issues, and optimize application performance. Their expertise includes advanced knowledge of Python frameworks, libraries, and development tools, as well as experience with databases, APIs, and cloud services.

What are the key skills and qualifications needed to thrive as a senior Python software engineer?

To thrive as a Senior Python Software Engineer, you need advanced proficiency in Python programming, strong problem-solving abilities, and a solid background in computer science or a related field. Familiarity with frameworks like Django or Flask, experience with version control systems such as Git, and knowledge of cloud platforms and CI/CD tools are typically required. Leadership, effective communication, and mentorship skills help you collaborate with teams and guide junior developers. These skills ensure the delivery of robust, scalable software solutions and foster a productive, innovative development environment.

What are some common challenges faced by senior Python software engineers when leading complex projects, and how can they be addressed?

Senior Python Software Engineers often face challenges such as balancing hands-on coding with mentoring junior team members, managing technical debt, and designing scalable solutions. Successfully addressing these challenges involves clear communication, proactive code reviews, and effective prioritization of tasks. Collaborating closely with cross-functional teams and fostering a culture of knowledge sharing can also help ensure project success and team growth.

What is the difference between Senior Python Software Engineer vs Python Developer?

AspectSenior Python Software EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in software engineeringBachelor's degree in CS or related field, coding proficiency
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing applications, debugging
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects
Common Search & Comparison IntentUnderstanding senior-level roles, responsibilities, and skillsEntry to mid-level coding roles, project involvement

The main difference between a Senior Python Software Engineer and a Python Developer lies in experience, responsibilities, and scope. Senior engineers typically lead projects, design system architecture, and mentor junior staff, while Python Developers focus on coding, application development, and implementation. Both roles require strong Python skills and relevant credentials, but senior roles demand more experience and leadership capabilities.

Which senior Python software engineer job is in demand?

Senior Python software engineering roles are in high demand across industries such as technology, finance, and healthcare, especially for positions involving data analysis, machine learning, and web development. Skills in frameworks like Django or Flask, along with experience in cloud platforms and version control, enhance job prospects in this field.

What are popular job titles related to Senior Python Software Engineer jobs in Indiana?

For Senior Python Software Engineer jobs in Indiana, the most frequently searched job titles are:

What job categories do people searching Senior Python Software Engineer jobs in Indiana look for?

The top searched job categories for Senior Python Software Engineer jobs in Indiana are:

What cities in Indiana are hiring for Senior Python Software Engineer jobs?

Cities in Indiana with the most Senior Python Software Engineer job openings:

Senior Python Software Engineer jobs near you
Infographic showing various Senior Python Software Engineer job openings in Indiana as of August 2026, with employment types broken down into 1% As Needed, 83% Full Time, 11% Part Time, and 5% Contract. Highlights an 87% Physical, 5% Hybrid, and 8% Remote job distribution.

Senior Software Engineer for Medical Device Startup

Levisonics, Inc.

Fishers, IN • On-site

$115K - $152K/yr

Full-time

Medical, Dental, Vision, PTO

Re-posted 28 days ago

Job description

About Us:
We are a dynamic and innovative medical device startup developing a point-of-care portable blood coagulation testing device. Our full-time team currently comprises a CEO/Biomedical Engineer, and an Electrical Engineer.
Job Summary:
We are seeking a talented and experienced Senior Software Engineer to join our team and lead the development and optimization of software workflows for our innovative acoustic tweezing technology-based medical devices. The ideal candidate will have a Master's degree in Computer Science, Software Engineering, or a related field, with a minimum of 5 years of experience. This role requires strong coding skills in Python and C/C++, proficiency in developing intuitive and visually engaging graphical user interfaces, and expertise in SQL for effective data management and database design. Experience with version control systems, particularly Git, is essential, along with the ability to understand and generate code from workflow diagrams. As the first and only software engineer on the team, you will play a pivotal role in shaping the software development efforts for our groundbreaking technology. This role is critical to the success of our product and involves working on multiple federal grants and projects.
Startup Environment:
We operate in a fast-paced startup environment where innovation, adaptability, and a proactive mindset are key to success. We are looking for individuals who are passionate about working in a startup setting and thrive in dynamic and challenging situations. We value individuals who are not just seeking a job but are driven by a genuine passion for creating impactful solutions and driving change in the medical device industry. Our team members are expected to work well under pressure, juggle multiple projects, and be flexible in their roles as the needs of the company evolve. If you are excited about the opportunity to make a meaningful impact and are ready to roll up your sleeves and tackle challenges head-on, we encourage you to apply.
Key Responsibilities:
  1. Optimize and Enhance Existing Software:
  • Improve the efficiency of our existing software written in Python.
  • Increase processing speed for short-term operation on laptops.
  • Convert and optimize the software for embedded computing devices inside the medical device long-term.
  1. Software Packaging and Security:
  • Secure the code to prevent reverse engineering.
  • Package the software into executable files for easy installation and deployment.
  1. Connectivity and Data Management:
  • Ensure the software can connect to the internet.
  • Implement connectivity to an online database for long-term data management.
  • Incorporate Data Science, Machine Learning, and AI for handling large amounts of health data.
  1. Health Data Security:
  • Ensure the highest level of security for software and health data management.
  1. New Technique Development:
  • Convert and develop existing crude MATLAB codes and technology algorithms into efficient software for commercial use.
  • Create executable files with efficient large data handling capabilities.
  • Develop complex data processing software and manage large data analysis.
  • Develop a user-friendly interface for healthcare professionals.
  • Implement a remote kill switch for the software.
  • Apply all relevant requirements from existing software.
  1. Parallel Processing and Language Conversion:
  • Implement efficient parallel processing techniques.
  • Convert existing Python code to C/C++ or another suitable low-level efficient language to run software optimally on embedded hardware.
  1. Other Responsibilities:
  • Develop high-quality, efficient, and maintainable code.
  • Design intuitive and visually engaging user interfaces.
  • Proactively take on new responsibilities and suggest innovative ideas for product and company growth.
  • Participate in grant writing and fundraising activities.
  • Engage in FDA-related activities and adhere to quality protocols.
  • Perform other relevant software-related tasks as needed for the company.

Minimum Qualifications:
  • Master's degree in Computer Science, Software Engineering, or a related field.
  • Minimum of 5 years of experience in software development.
  • Strong coding skills in Python, C, and C++ (JavaScript is a plus).
  • Proficiency in developing intuitive and visually engaging graphical user interfaces.
  • Proficiency in SQL for effective data management and database design.
  • Experience with version control systems, particularly Git.
  • Ability to understand and generate code from workflow diagrams.
  • Knowledge of integrating multiple devices and establishing centralized control.
  • Familiarity with IDEs, preferably PyCharm.
  • Excellent problem-solving skills and ability to work independently.
  • Strong written and verbal communication skills.

Preferred Qualifications:
  • Experience working in the medical device industry.
  • Familiarity with Agile development methodologies.
  • Knowledge of machine learning techniques and algorithms.
  • Experience with Docker and containerization technologies.
  • Familiarity with cloud platforms such as AWS or Azure.
  • Prior experience working in startups.
  • Experience with embedded systems and medical device software development.
  • Strong knowledge of data security, especially related to health data.
  • Knowledge of parallel processing and algorithm optimization.
  • Innovative mindset with a track record of proactive contributions.
  • Experience in grant writing and regulatory compliance (FDA).

What We Offer:
  • Competitive salary
  • Health, dental, and vision insurance coverage
  • Generous paid time off
  • Professional development opportunities
  • Potential to receive stock options
  • Opportunities for growth within the company
  • Flexible work arrangements, including remote work options
  • Dynamic and innovative startup environment
  • Opportunity to make a meaningful impact in the medical device industry

Apply