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Senior Python Developer Jobs in Saint Louis, MO (NOW HIRING)

ArchKey Solutions LLC

Senior Python Developer

Fenton, MO

$116K - $156K/yr

Description SR. PYTHON DEVELOPER This position is based out of our St Louis, MO office About ArchKey ArchKey is one of the nation's largest privately held specialty trade installation and integrated ...

ArchKey Solutions

Senior Python Developer

Fenton, MO

$116K - $156K/yr

SR. PYTHON DEVELOPER This position is based out of our St Louis, MO office About ArchKey ArchKey is one of the nation's largest privately held specialty trade installation and integrated facility ...

ArchKey Solutions

Senior Python Developer

Fenton, MO

$116K - $156K/yr

SR. PYTHON DEVELOPER This position is based out of our St Louis, MO office About ArchKey ArchKey is one of the nation's largest privately held specialty trade installation and integrated facility ...

Archkey Solutions LLC

Senior Python Developer

Fenton, MO · On-site

$116K - $156K/yr

Description SR. PYTHON DEVELOPER This position is based out of our S t Louis, MO office About ArchKey ArchKey is one of the nation's largest privately held specialty trade installation and integrated ...

InterSources

Senior Blockchain Developer

Chesterfield, MO · Hybrid

$54 - $71.25/hr

Senior Blockchain Developer Location: Chicago, IL, USA- Hybrid Duration: 12+ Month Contract ... Cryptography, GoLang, Java, NodeJs, Python, SDLC, Spring Boot Must have 10+ yrs of Blockchain ...

Futran Tech Solutions Pvt. Ltd.

Sr Developer

O Fallon, MO · On-site

$51 - $67.25/hr

Position : Sr Developer Location : O FALLON MO (Remote 2 Months) the Oniste JD Spark with Scala • ... or python • Should have good working experience/knowledge in SQL • Should have good ...

Arka Infotech Inc

Sr. Scala Developer

Saint Louis, MO

$53 - $70/hr

Louis, Missouri 08-03-2015 Senior Scala Developer w/hands-on experience writing Scala architecture on OS X and AWS models -- experience coding in Clojure, Java, and/or Python also a plus. Client is ...

Mastech Digital

Senior Cloud Developer

Saint Louis, MO · Remote

$50 - $65/hr

We are currently seeking a Senior Cloud Developer for our client in the Professional Services ... Strong scripting skills in PowerShell, Python, and Bash are essential. Experience with Azure API ...

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All JobsSenior Python Developer JobsSenior Python Developer Jobs in Saint Louis, MO

Senior Python Developer information

See Saint Louis, MO salary details

$51.5K

$132.9K

$182.6K

How much do senior python developer jobs pay per year?

As of Jun 21, 2026, the average yearly pay for senior python developer in Saint Louis, MO is $132,924.00, according to ZipRecruiter salary data. Most workers in this role earn between $113,800.00 and $153,100.00 per year, depending on experience, location, and employer.

What are the main responsibilities of a Senior Python Developer?

A Senior Python Developer is responsible for designing, developing, and maintaining complex software applications using the Python programming language. They lead the technical aspects of projects, mentor junior developers, and ensure code quality through code reviews and best practices. Additionally, they collaborate with cross-functional teams to gather requirements, solve technical challenges, and deploy scalable and efficient solutions. Senior Python Developers are also expected to stay updated with the latest trends and advancements in Python and related technologies.

What is the difference between Senior Python Developer vs Python Developer?

AspectSenior Python DeveloperPython Developer
Required ExperienceTypically 5+ years, with leadership and complex project experienceUsually 1-3 years, focusing on core Python skills
ResponsibilitiesDesigning architecture, mentoring, handling complex systemsWriting code, debugging, implementing features
CertificationsOptional but beneficial (e.g., Python certifications, cloud certs)Often not required
Work EnvironmentCollaborative teams, project planning, code reviewsDevelopment-focused, task-oriented

The main difference between a Senior Python Developer and a Python Developer lies in experience, responsibilities, and leadership. Senior developers handle complex projects, mentor others, and often participate in architecture decisions, while Python Developers focus on coding and feature implementation. Both roles are essential in tech companies, but the senior role requires more experience and broader skills.

What are the key skills and qualifications needed to thrive as a Senior Python Developer, and why are they important?

To thrive as a Senior Python Developer, you need advanced proficiency in Python programming, experience with software architecture, and a solid understanding of algorithms and data structures, usually backed by a degree in computer science or related fields. Familiarity with frameworks like Django or Flask, version control systems such as Git, and containerization tools like Docker are typically required, alongside knowledge of modern CI/CD pipelines. Strong problem-solving abilities, effective communication, and leadership skills help you collaborate with teams and mentor junior developers. Mastery of these skills ensures the delivery of scalable, maintainable software solutions and the ability to drive technical excellence within development teams.

What are some common challenges faced by Senior Python Developers when leading a development team?

Senior Python Developers often encounter challenges such as balancing hands-on coding with mentoring junior team members and ensuring code quality across the team. They are also responsible for making architectural decisions, which requires staying updated on best practices and emerging Python frameworks. Additionally, coordinating collaboration between cross-functional teams (like DevOps, QA, and front-end developers) can be complex, especially in agile environments where requirements may shift rapidly. Overcoming these challenges helps foster a productive and innovative team culture.
What are the most commonly searched types of Python Developer jobs in Saint Louis, MO? The most popular types of Python Developer jobs in Saint Louis, MO are:
What are popular job titles related to Senior Python Developer jobs in Saint Louis, MO? For Senior Python Developer jobs in Saint Louis, MO, the most frequently searched job titles are:
What job categories do people searching Senior Python Developer jobs in Saint Louis, MO look for? The top searched job categories for Senior Python Developer jobs in Saint Louis, MO are:
What cities near Saint Louis, MO are hiring for Senior Python Developer jobs? Cities near Saint Louis, MO with the most Senior Python Developer job openings:
Senior Python Developer jobs near you
Infographic showing various Senior Python Developer job openings in Saint Louis, MO as of June 2026, with employment types broken down into 70% Full Time, 10% Part Time, 10% Temporary, and 10% Contract. Highlights an 87% Physical, 5% Hybrid, and 8% Remote job distribution, with an average salary of $132,924 per year, or $63.9 per hour.

Senior Python Developer

Noor Staffing Group

Saint Louis, MO

$150K - $190K/yr

Other

Posted 3 hours ago

Job description

Position: Senior Python Developer

Location: St. Louis area (onsite)

Salary: $150,000 - $190,000 DOE + full benefits

What you need for this position:

Hold a TS/SCI Clearance

Experience with Python or similar backend programming language (Java, Golang, node.js)

Excellent communication and team skills

5+ years of Software Development experience

Apply