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Senior Python Developer Jobs in Saint Louis, MO (NOW HIRING)

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Java Developer

O Fallon, MO · On-site

$47.75 - $61.75/hr

The Sr. Software Engineer opportunity we have in St. Louis, MO. All candidates will be required to ... Python, Perl, PHP, JavaScript, Go). * Orchestrates the deployment/maintenance of complex ...

DCS Corp

Senior Level Software Developer

Saint Louis, MO

$53 - $70/hr

We are seeking a Software Engineer to support our client's intelligence analysis products and ... Java, JavaScript or Python enterprise application development. Web services architecture, design ...

Intellectix

Senior Storage Engineer

Arnold, MO · On-site

Senior Storage Engineer Location: Arnold, MO (On Customer Site) Clearance: TS/SCI Citizenship: US ... PowerShell/Python scripting experience. * Experience leveraging scripts to audit and enforce ...

Intellectix

Senior Storage Engineer

Arnold, MO

Senior Storage Engineer Location: Arnold, MO (On Customer Site) Clearance: TS/SCI Citizenship: US ... PowerShell/Python scripting experience. * Experience leveraging scripts to audit and enforce ...

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Senior Python Developer information

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$53.5K

$138K

$189.6K

How much do senior python developer jobs pay per year?

As of May 30, 2026, the average yearly pay for senior python developer in Saint Louis, MO is $138,032.00, according to ZipRecruiter salary data. Most workers in this role earn between $118,100.00 and $159,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Senior Python Developer, and why are they important?

To thrive as a Senior Python Developer, you need advanced proficiency in Python programming, experience with software architecture, and a solid understanding of algorithms and data structures, usually backed by a degree in computer science or related fields. Familiarity with frameworks like Django or Flask, version control systems such as Git, and containerization tools like Docker are typically required, alongside knowledge of modern CI/CD pipelines. Strong problem-solving abilities, effective communication, and leadership skills help you collaborate with teams and mentor junior developers. Mastery of these skills ensures the delivery of scalable, maintainable software solutions and the ability to drive technical excellence within development teams.

What are some common challenges faced by Senior Python Developers when leading a development team?

Senior Python Developers often encounter challenges such as balancing hands-on coding with mentoring junior team members and ensuring code quality across the team. They are also responsible for making architectural decisions, which requires staying updated on best practices and emerging Python frameworks. Additionally, coordinating collaboration between cross-functional teams (like DevOps, QA, and front-end developers) can be complex, especially in agile environments where requirements may shift rapidly. Overcoming these challenges helps foster a productive and innovative team culture.

What are the main responsibilities of a Senior Python Developer?

A Senior Python Developer is responsible for designing, developing, and maintaining complex software applications using the Python programming language. They lead the technical aspects of projects, mentor junior developers, and ensure code quality through code reviews and best practices. Additionally, they collaborate with cross-functional teams to gather requirements, solve technical challenges, and deploy scalable and efficient solutions. Senior Python Developers are also expected to stay updated with the latest trends and advancements in Python and related technologies.

What is the difference between Senior Python Developer vs Python Developer?

AspectSenior Python DeveloperPython Developer
Required ExperienceTypically 5+ years, with leadership and complex project experienceUsually 1-3 years, focusing on core Python skills
ResponsibilitiesDesigning architecture, mentoring, handling complex systemsWriting code, debugging, implementing features
CertificationsOptional but beneficial (e.g., Python certifications, cloud certs)Often not required
Work EnvironmentCollaborative teams, project planning, code reviewsDevelopment-focused, task-oriented

The main difference between a Senior Python Developer and a Python Developer lies in experience, responsibilities, and leadership. Senior developers handle complex projects, mentor others, and often participate in architecture decisions, while Python Developers focus on coding and feature implementation. Both roles are essential in tech companies, but the senior role requires more experience and broader skills.

What are the most commonly searched types of Python Developer jobs in Saint Louis, MO? The most popular types of Python Developer jobs in Saint Louis, MO are:
What are popular job titles related to Senior Python Developer jobs in Saint Louis, MO? For Senior Python Developer jobs in Saint Louis, MO, the most frequently searched job titles are:
What job categories do people searching Senior Python Developer jobs in Saint Louis, MO look for? The top searched job categories for Senior Python Developer jobs in Saint Louis, MO are:
What cities near Saint Louis, MO are hiring for Senior Python Developer jobs? Cities near Saint Louis, MO with the most Senior Python Developer job openings:
Senior Python Developer jobs near you
Infographic showing various Senior Python Developer job openings in Saint Louis, MO as of May 2026, with employment types broken down into 65% Full Time, 29% Part Time, and 6% Contract. Highlights an 92% Physical, 5% Hybrid, and 3% Remote job distribution, with an average salary of $138,032 per year, or $66.4 per hour.
Senior Software Engineer- Quantitative Developer, Information Technology

Senior Software Engineer- Quantitative Developer, Information Technology

NISA Investment Advisors, LLC

Saint Louis, MO • On-site

$114.70K - $151.20K/yr

Other

Medical, Dental, Vision, Life, Retirement, PTO

Posted 12 days ago

Job description

Overview
NISA Investment Advisors, LLC (NISA) offers customized investment solutions for tax-exempt and taxable institutional clients. NISA manages over $295 billion in fixed income and equity securities and over $167 billion in derivative notional value. We seek bright, motivated individuals who can contribute to our growing team of professionals. Candidates with a high degree of independent thinking skills, strong analytical and quantitative skills, and team playing abilities are encouraged to apply.
Responsibilities
As a Senior Software Engineer- Quantitative Developer in the Investment Risk and Analytics team, you will design and build the infrastructure that powers NISA's analytics and quantitative research workflows. Working closely with portfolio analysts, traders, and quant researchers, you will develop the tooling behind feature engineering frameworks, backtesting infrastructure, and model deployment - enabling the research team to move faster and with greater confidence. You will also work with teams to develop the core analytical systems to support risk and valuation tools. As a senior member of the Investment Risk and Analytics team within NISA's IT department, you will lead development efforts, participate in design and code reviews, collaborate with other teams, and mentor junior teammates.
Qualifications
  • Bachelor's degree or equivalent experience in a field requiring strong analytical and quantitative skills, such as Computer Science, Engineering, Mathematics, Finance, or Information Systems
  • 5+ years of development experience including 3+ years of using Python (expertise in other high-level languages considered)
  • Experience designing queries and data structures to support and manage analytical model development
  • Experience collaborating with quantitative researchers, data scientists, or similar technical stakeholders
  • Ability to analyze results and detect data quality issues and their root causes
  • Experience building solutions using public cloud platforms (AWS, Azure, GCP) preferred
  • Familiarity with quantitative finance workflows - backtesting, feature engineering, factor research, or portfolio analytics is a plus
  • Experience with unit testing and CI/CD practices preferred
  • Familiarity with data science is a plus
  • Working knowledge of modern application frameworks is a plus
  • Previous professional experience in financial services sector is a plus

NISA's culture encourages collaboration and innovation. We seek self-motivated, intellectually curious individuals willing to push themselves and others in an environment that celebrates fresh thinking. We equip employees with the resources needed to excel and we encourage personal development. NISA is dedicated to internally cultivating and rewarding talent. Employees at NISA are provided with a wide range of benefits, including health, dental, vision and life insurance options, paid time off, a competitive retirement plan, onsite cafeteria, fitness center, a health and wellness program and an educational assistance program.
NISA is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.

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