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Senior Python Developer Jobs in Saint Louis, MO (NOW HIRING)

DLS Engineering

Senior Software Engineer

Saint Louis, MO · On-site

$118K - $126K/yr

This role requires strong full-stack Python experience, with a focus on API development, Kubernetes deployment, and modern DevOps practices to accelerate delivery. The Senior Software Engineer will ...

Elite Technical

Sr. Elastic Engineer

Scott Air Force Base, IL · On-site

$110K - $151K/yr

... DevOps, cloud, and client teams to deliver resilient, high-performance Elastic solutions while ... Write scripts, automation, and integrations (Python, PowerShell, Bash, etc.) to streamline ...

ECS

Sr. Elastic Engineer

Scott Air Force Base, IL · On-site

$100K - $138K/yr

... DevOps, cloud, and client teams to deliver resilient, high-performance Elastic solutions while ... Write scripts, automation, and integrations (Python, PowerShell, Bash, etc.) to streamline ...

D&G Support Services, LLC

Senior Developer

Saint Louis, MO · On-site

$125K - $150K/yr

Senior Developer On Site | Scott AFB, IL | Secret Clearance Required If you enjoy building modern ... Python. • Experience developing and maintaining data pipelines using Apache Spark, Kafka, or ...

Boeing

Senior Cloud DevOps Developer

Hazelwood, MO

$136K - $185K/yr

Senior Cloud DevOps Developer Company: The Boeing Company The Boeing Company is currently seeking a ... Ansible, Python, or Bourne Again Shell * 3+ years of experience with containerization and ...

Boeing

Senior Cloud DevOps Developer

Hazelwood, MO · On-site

$136K - $185K/yr

Senior Cloud DevOps Developer Company: The Boeing Company The Boeing Company is currently seeking a ... Ansible, Python, or Bourne Again Shell * 3+ years of experience with containerization and ...

Boeing

Senior Cloud DevOps Developer

Hazelwood, MO · On-site

$136K - $185K/yr

Senior Cloud DevOps Developer Company: The Boeing Company The Boeing Company is currently seeking a ... Ansible, Python, or Bourne Again Shell * 3+ years of experience with containerization and ...

Navtech, Inc.

Sr AWS Developer

Saint Louis, MO · On-site

Job Title: Sr AWS Developer Location: St Louis, MO - Remote Start Duration: 6+ Months Contract then ... Java/Python/Scala * Strong notions of security best practices (e.g. using IAM Roles, KMS, etc.

Abode Techzone LLC

Senior Software Engineer

Saint Louis, MO · On-site

$119K - $157K/yr

Senior Software Engineer - Full Stack & Secure Systems We are seeking an experienced and driven ... Experience with backend languages such as Go, Node.js, or Python * Familiarity with Linux-based ...

MasterCard

Senior Software Engineer

O Fallon, MO

$114K - $151K/yr

Strict Must-Haves (Non-Negotiable) Python - Proven experience building and operationalizing ... native and DevOps technologies (e.g., Docker, CI/CD pipelines, PCF or other cloud platforms ...

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All JobsSenior Python Developer JobsSenior Python Developer Jobs in Saint Louis, MO

Senior Python Developer information

See Saint Louis, MO salary details

$53.5K

$138K

$189.6K

How much do senior python developer jobs pay per year?

As of Jun 26, 2026, the average yearly pay for senior python developer in Saint Louis, MO is $138,032.00, according to ZipRecruiter salary data. Most workers in this role earn between $118,100.00 and $159,000.00 per year, depending on experience, location, and employer.

What are the main responsibilities of a Senior Python Developer?

A Senior Python Developer is responsible for designing, developing, and maintaining complex software applications using the Python programming language. They lead the technical aspects of projects, mentor junior developers, and ensure code quality through code reviews and best practices. Additionally, they collaborate with cross-functional teams to gather requirements, solve technical challenges, and deploy scalable and efficient solutions. Senior Python Developers are also expected to stay updated with the latest trends and advancements in Python and related technologies.

What is the difference between Senior Python Developer vs Python Developer?

AspectSenior Python DeveloperPython Developer
Required ExperienceTypically 5+ years, with leadership and complex project experienceUsually 1-3 years, focusing on core Python skills
ResponsibilitiesDesigning architecture, mentoring, handling complex systemsWriting code, debugging, implementing features
CertificationsOptional but beneficial (e.g., Python certifications, cloud certs)Often not required
Work EnvironmentCollaborative teams, project planning, code reviewsDevelopment-focused, task-oriented

The main difference between a Senior Python Developer and a Python Developer lies in experience, responsibilities, and leadership. Senior developers handle complex projects, mentor others, and often participate in architecture decisions, while Python Developers focus on coding and feature implementation. Both roles are essential in tech companies, but the senior role requires more experience and broader skills.

What are the key skills and qualifications needed to thrive as a Senior Python Developer, and why are they important?

To thrive as a Senior Python Developer, you need advanced proficiency in Python programming, experience with software architecture, and a solid understanding of algorithms and data structures, usually backed by a degree in computer science or related fields. Familiarity with frameworks like Django or Flask, version control systems such as Git, and containerization tools like Docker are typically required, alongside knowledge of modern CI/CD pipelines. Strong problem-solving abilities, effective communication, and leadership skills help you collaborate with teams and mentor junior developers. Mastery of these skills ensures the delivery of scalable, maintainable software solutions and the ability to drive technical excellence within development teams.

What are some common challenges faced by Senior Python Developers when leading a development team?

Senior Python Developers often encounter challenges such as balancing hands-on coding with mentoring junior team members and ensuring code quality across the team. They are also responsible for making architectural decisions, which requires staying updated on best practices and emerging Python frameworks. Additionally, coordinating collaboration between cross-functional teams (like DevOps, QA, and front-end developers) can be complex, especially in agile environments where requirements may shift rapidly. Overcoming these challenges helps foster a productive and innovative team culture.
What are the most commonly searched types of Python Developer jobs in Saint Louis, MO? The most popular types of Python Developer jobs in Saint Louis, MO are:
What are popular job titles related to Senior Python Developer jobs in Saint Louis, MO? For Senior Python Developer jobs in Saint Louis, MO, the most frequently searched job titles are:
What job categories do people searching Senior Python Developer jobs in Saint Louis, MO look for? The top searched job categories for Senior Python Developer jobs in Saint Louis, MO are:
What cities near Saint Louis, MO are hiring for Senior Python Developer jobs? Cities near Saint Louis, MO with the most Senior Python Developer job openings:
Senior Python Developer jobs near you
Infographic showing various Senior Python Developer job openings in Saint Louis, MO as of June 2026, with employment types broken down into 100% Contract. Highlights an 100% In-person job distribution, with an average salary of $138,032 per year, or $66.4 per hour.
Senior AI/ML Scientist

Senior AI/ML Scientist

GLOBAL IT CON LLC

Saint Louis, MO • On-site

Other

Posted 4 days ago

Job description

Position: Senior AI/ML Scientist
Location: St. Louis, MO (Hybrid)
Type: Contract
Experience: 8 10+ Years

Job Summary

We are seeking a highly skilled Senior AI/ML Scientist to design, build, and scale machine learning systems that drive personalization, customer intelligence, and data-driven decision-making. The ideal candidate will work at the intersection of traditional machine learning, advanced statistical modeling, and emerging Generative AI and Agentic AI technologies to deliver impactful business solutions.

Key Responsibilities

Design, develop, and deploy production-grade propensity models, recommendation engines, and predictive machine learning solutions.

Lead applied research initiatives and perform rigorous statistical analysis to support model development and business strategy.

Build, train, and operationalize machine learning models on Google Cloud Platform (Google Cloud Platform) using services such as Vertex AI, BigQuery ML, Dataflow, and Cloud Run.

Develop and integrate Generative AI and Agentic AI capabilities into existing ML workflows and business applications.

Collaborate with data engineering teams to design feature stores, model training pipelines, and monitoring frameworks.

Translate complex business challenges into scalable machine learning solutions.

Present findings and recommendations to both technical and non-technical stakeholders.

Mentor junior data scientists and contribute to best practices across modeling, experimentation, and MLOps.

Required Qualifications

8 10+ years of experience in Machine Learning, Data Science, or related fields.

Advanced degree (Master's or PhD preferred) in Computer Science, Statistics, Machine Learning, Applied Mathematics, or a related quantitative discipline.

Strong experience building and deploying machine learning models in production environments.

Expertise in propensity modeling, recommendation systems, predictive analytics, and statistical analysis.

Hands-on experience with Google Cloud Platform (Google Cloud Platform), including Vertex AI, BigQuery, Dataflow, and Cloud Run.

Strong knowledge of Generative AI and Agentic AI concepts, including:

  • Large Language Models (LLMs)
  • Retrieval-Augmented Generation (RAG)
  • Prompt Engineering
  • Agent Frameworks
  • Model Evaluation Techniques

Advanced Python programming skills.

Experience with machine learning frameworks such as:

  • TensorFlow
  • PyTorch
  • Scikit-learn
  • Pandas
  • NumPy
Required Skills

Machine Learning
AI/ML Model Development
Recommendation Systems
Propensity Modeling
Statistical Analysis
Generative AI
Agentic AI
LLMs
RAG
Prompt Engineering
Python
TensorFlow / PyTorch
Google Cloud Platform (Google Cloud Platform)
Vertex AI
BigQuery
MLOps

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