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Senior Mes Engineer Jobs in Raleigh, NC (NOW HIRING)

GlaxoSmithKline

Automation Engineer

Zebulon, NC · On-site

Bachelor's degree in engineering, Instrumentation, Controls, Computer Science, or a related ... and senior management within the organization. * Experience with SCADA, MES integration, or ...

GSK

Automation Engineer

Zebulon, NC · On-site

Bachelor's degree in engineering, Instrumentation, Controls, Computer Science, or a related ... and senior management within the organization. * Experience with SCADA, MES integration, or ...

Visium Resources, Inc.

Be Seen First

Pharmaceutical Engineer

Raleigh, NC · On-site

$120K - $145K/yr

Summary We are seeking a highly motivated Senior CQV Engineer to support commissioning ... MES systems * SCADA platforms * Kneat or electronic validation systems * PMP certification or ...

ALLIANCE BIOTECH SOLUTIONS LLC

CSV Engineer

Raleigh, NC · On-site

Description The Senior Computer System Validation (CSV) Engineer is responsible for leading the ... MES, ERP, PI Historian, and related GxP systems. Verify data integrity, security, audit trail, and ...

Alliance Biotech Solutions LLC

CSV Engineer

Raleigh, NC · On-site

The Senior Computer System Validation (CSV) Engineer is responsible for leading the validation of ... MES, ERP, PI Historian, and related GxP systems. · Verify data integrity, security, audit trail ...

Actalent

Integration Engineer

Raleigh, NC

$45 - $60/hr

Integration Engineer We are seeking a Sr. Integration Engineer to provide technical support ... Proficient with MES/SCADA, PLCs, and industrial networks. * Knowledge of industrial protocols such ...

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All JobsMes Engineer JobsSenior Mes Engineer JobsSenior Mes Engineer Jobs in Raleigh, NC

Senior Mes Engineer information

See Raleigh, NC salary details

$57.8K

$123K

$178.4K

How much do senior mes engineer jobs pay per year?

As of Aug 10, 2026, the average yearly pay for senior mes engineer in Raleigh, NC is $123,024.00, according to ZipRecruiter salary data. Most workers in this role earn between $101,600.00 and $139,500.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Senior MES Engineer?

To thrive as a Senior MES Engineer, you need deep knowledge of Manufacturing Execution Systems, process automation, and systems integration, typically supported by an engineering degree and relevant industry experience. Familiarity with MES platforms (such as Siemens Opcenter, Rockwell FactoryTalk, or GE Proficy), industrial protocols, and certifications like PMP or Six Sigma can be highly valuable. Strong problem-solving, project management, and communication skills help you lead complex deployments and collaborate effectively with cross-functional teams. These abilities ensure that critical manufacturing processes are optimized, compliant, and efficiently supported in dynamic production environments.

What is a Senior MES Engineer?

A Senior MES (Manufacturing Execution Systems) Engineer is responsible for designing, developing, implementing, and maintaining MES solutions to optimize manufacturing processes. They work closely with production, IT, and engineering teams to ensure seamless integration between MES systems and enterprise applications like ERP and SCADA. Their role includes troubleshooting system issues, improving workflows, and ensuring data accuracy for real-time decision-making. Additionally, they may mentor junior engineers and lead system upgrades or implementations to enhance production efficiency and compliance.

What are some typical challenges faced by Senior MES Engineers in their daily work?

Senior MES Engineers often face challenges such as integrating new MES solutions with legacy systems, managing diverse stakeholder expectations, and ensuring minimal disruption during system upgrades or rollouts. Balancing multiple projects across different production lines while maintaining system reliability and compliance can also be demanding. This role frequently requires creative problem-solving to troubleshoot real-time issues and the ability to communicate technical concepts clearly to both technical and non-technical colleagues. Overcoming these challenges is key to driving continuous improvement and efficiency within modern manufacturing environments.

What are the most commonly searched types of Mes Engineer jobs in Raleigh, NC? The most popular types of Mes Engineer jobs in Raleigh, NC are:
What are popular job titles related to Senior Mes Engineer jobs in Raleigh, NC? For Senior Mes Engineer jobs in Raleigh, NC, the most frequently searched job titles are:
What job categories do people searching Senior Mes Engineer jobs in Raleigh, NC look for? The top searched job categories for Senior Mes Engineer jobs in Raleigh, NC are:
What cities near Raleigh, NC are hiring for Senior Mes Engineer jobs? Cities near Raleigh, NC with the most Senior Mes Engineer job openings:
Senior Mes Engineer jobs near you
Infographic showing various Senior Mes Engineer job openings in Raleigh, NC as of July 2026, with employment types broken down into 93% Full Time, 4% Part Time, and 3% Contract. Highlights an 89% Physical, 4% Hybrid, and 7% Remote job distribution, with an average salary of $123,024 per year, or $59.1 per hour.

Mfg Technologies Sr Mgr - Holly Springs, NC

MSCCN

Holly Springs, NC • On-site

$100K/yr

Full-time

Medical, Dental, Vision, Life, Retirement

Posted 12 days ago

Job description


ATTENTION MILITARY AFFILIATED JOB SEEKERS - Our organization works with partner companies to source qualified talent for their open roles. The following position is available to Veterans, Transitioning Military, National Guard and Reserve Members, Military Spouses, Wounded Warriors, and their Caregivers. If you have the required skill set, education requirements, and experience, please click the submit button and follow the next steps. Unless specifically stated otherwise, this role is "On-Site" at the location detailed in the job post.
Manufacturing Technologies Senior Manager
What you will do
Let's do this. Let's change the world. In this vital role, you will manage a defined set of Manufacturing Execution Systems (MES) objects, such as GMBRs (electronic batch records) and equipment management objects (ESPs, state diagrams), that are utilized across all applicable manufacturing sites.
Specific responsibilities include but are not limited to:
Collaborate, communicate be accountable for leading forums with multi-functional areas and make the appropriate decisions for the best interest of Amgen.
May include ownership of global MES SOPs in addition of provide input and review of related global training materials.
Strategize with Technology team on application roadmap and accommodating new offered functionality.
Own system related controlled documents such as data integrity assessment report, operational SOPs, and training content.
Lead and approve validation documents and records such as validation plan, OQ protocol, configuration specifications, requirements specs, validation summary (backup) report, test scripts, test sets, and test runs mostly for MES but also some for ERP.
Additional Qualifications/Responsibilities
Basic Qualifications:
Doctorate degree and 2 years of Manufacturing support experience
OR
Master's degree and 4 years of Manufacturing support experience
OR
Bachelor's degree and 6 years of Manufacturing support experience
Or
Associate's degree and 10 years of Manufacturing support experience
Or
High School diploma / GED and 12 years of Manufacturing support experience
Beyond that, additional preferred qualifications are:
Academic background in Life Science, and/or Engineering.
Leadership experience managing contractors and indirect reports.
Background in Drug Substance, Finish Drug Product (FDP) and/or Drug Product.
MES technology knowledge with experience modifying batch records.
Proficient communication skills in English.
Experience with MBR design in Koerber's PAS X.
MES system experience in biological manufacturing floor operations.
Regulated environment work experience with cross-functional collaboration, working in teams.
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental & vision coverage, life and disability insurance
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models, including remote and hybrid work arrangements, where possible
Salary Range
137,416.10USD -185,915.90 USD

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