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Senior Mes Engineer Jobs (NOW HIRING)

Staffingine LLC

Senior MES Engineer

Raleigh, NC · On-site

$101K - $139K/yr

Senior MES Engineer Job Location: Raleigh, NC Job Type: Full-Time * This position requires demonstrated technical proficiency in software design and configuration of MES solutions with integration ...

Bristol-Myers Squibb Company

Senior MES Engineer

Devens, MA · On-site

$108K - $131K/yr

The Senior MES Engineer is a strong technical subject matter expert (SME) responsible for the design, implementation, and support of Manufacturing Execution System (MES) solutions within the Devens ...

Bristol Myers Squibb

Senior MES Engineer

Devens, MA · On-site

$108K - $131K/yr

The Senior MES Engineer is a strong technical subject matter expert (SME) responsible for the design, implementation, and support of Manufacturing Execution System (MES) solutions within the Devens ...

INCOG BioPharma Services

Senior MES Engineer

Fishers, IN

$94K - $129K/yr

Senior MES Engineer Summary INCOG BioPharma is seeking a highly motivated individual with subject matter expert (SME) capabilities in sterile pharmaceutical manufacturing process controls and ...

INCOG BioPharma Services

Senior MES Engineer

Fishers, IN · On-site

$97K - $134K/yr

Description Senior MES Engineer Summary INCOG BioPharma is seeking a highly motivated individual with subject matter expert (SME) capabilities in sterile pharmaceutical manufacturing process controls ...

INCOG BioPharma Services

Senior MES Engineer

Fishers, IN

$94K - $129K/yr

Senior MES Engineer Summary INCOG BioPharma is seeking a highly motivated individual with subject matter expert (SME) capabilities in sterile pharmaceutical manufacturing process controls and ...

head-huntress.com

Senior MES Engineer

Raleigh, NC · On-site

$101K - $139K/yr

The Senior MES Engineer will interact directly with the customer and lead a team of Wunderlich-Malec engineers in identifying requirements, evaluating MES platforms, developing specifications, and ...

INCOG

Senior MES Engineer

Fishers, IN

$97K - $134K/yr

Senior MES Engineer Summary INCOG BioPharma is seeking a highly motivated individual with subject matter expert (SME) capabilities in sterile pharmaceutical manufacturing process controls and ...

Upcoresolutions

Senior MES Engineer

Raleigh, NC

$101K - $139K/yr

The Senior MES Engineer will interact directly with the customer and lead a team of engineers in identifying requirements, evaluating MES platforms, developing specifications, and implementing ...

ATS Automation Tooling Systems

Senior MES Engineer

Raleigh, NC · On-site

$101K - $139K/yr

Your responsibilities We are seeking a Senior MES Engineer to support the expansion of our Manufacturing Execution Systems (MES) practice and provide on-site engineering support for pharmaceutical ...

ATS Automation

Senior MES Engineer

Raleigh, NC · On-site

$101K - $139K/yr

Your responsibilities We are seeking a Senior MES Engineer to support the expansion of our Manufacturing Execution Systems (MES) practice and provide on-site engineering support for pharmaceutical ...

GSK

Senior MES Engineer

King Of Prussia, PA · On-site

$104K - $142K/yr

The Sr. MES Engineer will provide engineering and technical support for manufacturing execution systems in the Biopharmaceutical Operations facility. Evaluate and develop technology, plan and ...

GlaxoSmithKline

Senior MES Engineer

King Of Prussia, PA

$104K - $142K/yr

The Sr. MES Engineer will provide engineering and technical support for manufacturing execution systems in the Biopharmaceutical Operations facility. Evaluate and develop technology, plan and ...

Mescada

Senior MES Engineer

Covington, GA · On-site

$88K - $121K/yr

Participate in the design, configuration, programming, testing, and documentation of the PAS-X MES implementation. * Lead the deployment of the PAS-X system to site, ensuring successful installation ...

Paper Converting Machine

Sr. MES Engineer

Roseville, CA · On-site

$115 - $150K/hr

As a MES Engineer III for the Information Solutions team you will have overall responsibility to lead and develop projects with clients across multiple industry sectors primarily focused on ...

Paper Converting Machine

Sr. MES Engineer

Denver, CO · On-site

$115 - $150K/hr

As a MES Engineer III for the Information Solutions team you will have overall responsibility to lead and develop projects with clients across multiple industry sectors primarily focused on ...

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Senior Mes Engineer information

See salary details

$59.5K

$126.6K

$183.5K

How much do senior mes engineer jobs pay per year?

As of Jun 19, 2026, the average yearly pay for senior mes engineer in the United States is $126,557.00, according to ZipRecruiter salary data. Most workers in this role earn between $104,500.00 and $143,500.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Senior Mes Engineer position, and why are they important?

To thrive as a Senior MES Engineer, you need deep knowledge of Manufacturing Execution Systems, process automation, and systems integration, typically supported by an engineering degree and relevant industry experience. Familiarity with MES platforms (such as Siemens Opcenter, Rockwell FactoryTalk, or GE Proficy), industrial protocols, and certifications like PMP or Six Sigma can be highly valuable. Strong problem-solving, project management, and communication skills help you lead complex deployments and collaborate effectively with cross-functional teams. These abilities ensure that critical manufacturing processes are optimized, compliant, and efficiently supported in dynamic production environments.

What is a Senior MES Engineer job?

A Senior MES (Manufacturing Execution Systems) Engineer is responsible for designing, developing, implementing, and maintaining MES solutions to optimize manufacturing processes. They work closely with production, IT, and engineering teams to ensure seamless integration between MES systems and enterprise applications like ERP and SCADA. Their role includes troubleshooting system issues, improving workflows, and ensuring data accuracy for real-time decision-making. Additionally, they may mentor junior engineers and lead system upgrades or implementations to enhance production efficiency and compliance.

What are some typical challenges faced by Senior MES Engineers in their daily work?

Senior MES Engineers often face challenges such as integrating new MES solutions with legacy systems, managing diverse stakeholder expectations, and ensuring minimal disruption during system upgrades or rollouts. Balancing multiple projects across different production lines while maintaining system reliability and compliance can also be demanding. This role frequently requires creative problem-solving to troubleshoot real-time issues and the ability to communicate technical concepts clearly to both technical and non-technical colleagues. Overcoming these challenges is key to driving continuous improvement and efficiency within modern manufacturing environments.

More about Senior Mes Engineer jobs
What cities are hiring for Senior Mes Engineer jobs? Cities with the most Senior Mes Engineer job openings:
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Senior Mes Engineer jobs near you
Infographic showing various Senior Mes Engineer job openings in the United States as of June 2026, with employment types broken down into 97% Full Time, and 3% Contract. Highlights an 87% Physical, 5% Hybrid, and 8% Remote job distribution, with an average salary of $126,557 per year, or $60.8 per hour.
Senior MES Engineer

Senior MES Engineer

Staffingine LLC

Raleigh, NC • On-site

$101K - $139K/yr

Full-time

Posted 29 days ago

Job description

Job Title: Senior MES Engineer
Job Location: Raleigh, NC
Job Type: Full-Time


Job Description:

  • This position requires demonstrated technical proficiency in software design and configuration of MES solutions with integration capabilities to level two and four systems.
  • The Senior MES Engineer will interact directly with the customer and lead a team of Wunderlich-Malec engineers in identifying requirements, evaluating MES platforms, developing specifications, and implementing/testing/commissioning/qualifying MES solutions.
  • This position is a leadership role within the business unit and requires strong problem-solving ability, well-balanced people skills, an aptitude for business efficiency, and an interest in creating partnerships.
  • The Senior MES Engineer demonstrates success by securing repeat work with both new and existing customers.
  • This position requires the ability to deliver innovative MES solutions and design standards either self-directedly or as a leader of a team.
  • The candidate will act as a solution architect and must have the ability to conceptualize, detail, and implement MES Solutions for industrial processes and machinery that meet our customers’ requirements.
  •  This involves the development of an MES strategy that integrates process knowledge, equipment design, and quality standards with information technology to reduce downtime, elevate the level of regulatory compliance, and introduce efficiency gains through the effective use of available technologies.
  • This position oftentimes requires the following project management responsibilities: developing project execution plans, work breakdown structures, and associated budgets, task prioritization and scheduling, task ordering, time tracking, and reporting, financial tracking and reporting, early problem identification, conflict management/resolution, leading and supporting a team, and attending project status meetings.
  • Also includes overseeing daily operations and activities of a project(s) up to $1M.  This position is often responsible for ensuring the overall profitability of the project.
  • The ideal candidate must have a diverse engineering skillset with the ability to work independently. Will act as technical lead on projects and guide lower-level engineers and technicians.  Could also act as Project Manager on smaller projects.