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The Senior Scientist II - Translational Pathologist will support tissue-based pathology activities across MacroGenics’ antibody-drug conjugate (ADC) and immunotherapy programs from discovery through IND-enabling studies and early clinical development. This role is responsible for execution of day-to-day histopathologic and biomarker pathology activities, including slide review, assay support, digital pathology analysis, and coordination with external CROs.

The position will work closely with the Senior Director of Pathology and cross-functional team members to deliver high-quality pathology data that informs target selection, translational strategy, safety assessment, and development decisions. Scientific and regulatory accountability remains with senior pathology leadership.

Responsibilities and Job Duties

Preclinical & Translational Pathology

• Perform necropsy and primary histopathologic assessment of tissues from in vivo pharmacology studies, including H&E, IHC, and multiplex immunofluorescence.
• Conduct first-pass assessment of target expression, on-target/off-tumor findings, ADC payload-related tissue injury, and tumor-immune microenvironment features relevant to immunotherapy programs.
• Prepare draft pathology interpretations, figures, and written summaries for internal review and program discussions.

Biomarker & Assay Support

• Execute pathology components of translational biomarker strategies as defined by senior Pathology and Translational Medicine leadership.
• Support development, optimization, and validation of single plex IHC and multiplex IHC and IF assays.
• Perform tissue annotation and support development and optimization of digital pathology and image analysis algorithms under the guidance of the Senior Director of Pathology.
• Contribute pathology data and figures to internal reports, study summaries, and regulatory-supporting documentation.
• Coordinate biomarker assay development and validation with CROs.

Documentation & Data Stewardship

• Draft pathology sections for study reports, slide decks, and internal presentations.
• Maintain pathology image libraries, annotations, and reference materials.
• Support development and maintenance of pathology-related SOPs, templates, and best practices.

Cross-Functional Collaboration

• Present pathology findings in internal project team meetings.
• Escalate and communicate complex findings, safety signals, or interpretation questions to the Translational Medicine leadership.

Minimum Qualifications

Education & Experience

• MD, DVM, or PhD with formal training in pathology, histopathology, or a closely related discipline.
• 3–5 years of experience in biomarker target validation, translational research, biotechnology, pharmaceutical, or CRO environments.

Skills & Abilities

• Hands-on experience with histopathologic and immunohistochemical tissue evaluation.
• Excellent pathology diagnostic skills.
• Skilled in mIF development, validation and spatial analysis.
• Experience with digital pathology and image analysis platforms (e.g., HALO, QuPath).
• Strong scientific writing and communication skills.

Preferred Qualifications

• MD/DVM strongly preferred.
• Experience supporting ADC, immuno-oncology, or T-cell engager programs.
• Experience working with AI/ML algorithms for digital pathology analysis.
• Exposure to GLP toxicology studies and nonclinical safety assessments.
• Experience working with external CROs.

Additional Information 

The annual rate of pay for the Senior Scientist II position ranges from $126,200-192,500. This role is eligible for the Company’s discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Company’s benefits programs, including medical / dental / vision / prescription coverage, employee wellness resources, 401(k) plan with employer match, access to an Employee Stock Purchase Plan, (ESPP), paid time off & paid parental leave benefits, and disability benefits. 

The annual pay rate range is described in good faith, and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidate’s experience, qualifications, geographic location, and other factors permitted by law. The Company may ultimately pay more or less than the posted range, and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned, vested, and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus, commission, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole discretion unless and until paid and may be modified at the Company’s sole discretion, consistent with the law.