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How much do senior director statistical programming jobs pay per year?

As of Aug 19, 2026, the average yearly pay for senior director statistical programming in the United States is $99,008.00, according to ZipRecruiter salary data. Most workers in this role earn between $87,000.00 and $107,000.00 per year, depending on experience, location, and employer.

What is the difference between Senior Director Statistical Programming vs Statistical Programming Manager?

AspectSenior Director Statistical ProgrammingStatistical Programming Manager
CredentialsAdvanced degree (MS/PhD), extensive experience in statistical programmingBachelor's or Master's degree, several years of experience
Work EnvironmentStrategic leadership, cross-functional collaboration, high-level decision makingTeam management, project oversight, technical execution
Employer & Industry UsagePharmaceuticals, biotech, clinical research organizationsPharmaceuticals, biotech, clinical research organizations
Search & Comparison IntentUnderstanding senior leadership roles in statistical programmingManaging statistical programming teams and projects

The Senior Director Statistical Programming typically holds a strategic leadership role with extensive experience and oversees multiple teams or departments. In contrast, the Statistical Programming Manager focuses on managing day-to-day project execution and team management. Both roles are vital in clinical research, but the senior director operates at a higher strategic level.

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Senior Director Statistical Programming jobs near you
Infographic showing various Senior Director Statistical Programming job openings in the United States as of August 2026, with employment types broken down into 2% As Needed, 83% Full Time, 12% Part Time, 1% Temporary, and 2% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $99,008 per year, or $47.6 per hour.

Associate Director, Statistical Programming

Zenas BioPharma

Waltham, MA • Hybrid

$171K - $214K/yr

Full-time

Posted 21 days ago

Job description

Position Summary:

The Associate Director, Statistical Programming will independently lead and execute programming activities aligned with project strategies to support clinical studies, study reports, and regulatory submissions. This role extends beyond study support to include strategic contributions to departmental infrastructure, such as process optimization and tool development. The position also involves direct management and oversight of internal, contract, and FSP programming resources.

Key Responsibilities:

  • Act as the primary statistical programming contact and knowledge expert for assigned protocols, studies, and integrated analyses.
  • Provide oversight of statistical programming activities, including those of internal staff, CROs, and FSP teams. Ensure deliverables meet quality standards, study timelines, and agreed scope.
  • Collaborate across functions (e.g., Biostatistics, Data Management, Clinical Operations) to provide expert programming support and strategic input.
  • Lead or contribute to departmental initiatives for process improvement, standardization, and the development or implementation of programming tools and macros to enhance efficiency and quality.
  • Review and provide expert input on SDTM and ADaM specifications, datasets, define.xml, reviewers guides, and validation reports.
  • Perform QC of SDTM datasets, ADaM datasets, and Tables, Figures, and Listings (TFLs).
  • Program TFLs for ad hoc analyses, posters, publications, and regulatory interactions.
  • Participate in the review of clinical study protocols, statistical analysis plans, and mock TFL shells.
  • Mentor, guide, and provide line management to junior programmers and assigned contract/FSP resources.
  • Manage relationships and performance with contract programming resources and Functional Service Providers (FSP).

Qualifications:

  • Master's degree in Biostatistics, Computer Science or related discipline, 7+ years' experience working across all phases of clinical trials in CRO/Biotech/ Pharmaceutical company; or Bachelor's degree with 9+ years of relevant experience.
  • Experience managing CROs and vendors.
  • NDA/BLA and other regulatory filing experience.
  • Experience with ISS/ISE.
  • Strong knowledge of CDISC standards for SDTM and ADaM.
  • Strong knowledge of ICH, FDA, EMA, and NMPA regulations and guidelines.
  • Exceptional interpersonal skills and problem-solving capabilities.
  • Excellent oral and written communication skills.
  • Experience working with cross-functional teams.
  • Excellent SAS programming skills.
  • Experience with other statistical software tools (e.g., R) preferred.
  • Comfortable working in a demanding, fast-paced, start-up culture with evolving processes. Flexible and able to adapt to new situations as the business demands.
  • Demonstrates flexibility to work non-traditional work hours when needed, given international operations across time zones.

#LI-Hybrid

The position is eligible for a competitive compensation and benefits package.

Zenas is committed to fair and equitable compensation practices. The base salary pay range for this role is $171,500 to $214,423. Actual compensation packages will depend on various factors, including, but not limited to depth of experience, education, skillset, overall performance and/or location.

Zenas believes in providing a competitive compensation and benefits package to all employees. Our base salary is just one component of Zenas' competitive total rewards strategy that also includes annual performance bonus, equity, full range of benefits and other incentive compensation plans.

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