ZipRecruiter

Log In

1

Senior Director Protein Engineering Jobs (NOW HIRING)

Amgen

Senior Director - BioIntelligence What you will do Let's do this. Let's change the world. The AI ... These capabilities support programs across discovery, protein engineering, immunology, and ...

Manifold Bio

Senior Director, Biotherapeutics

Boston, MA

$240K - $340K/yr

Our team of protein engineers, biologists, and computational scientists works across this full ... Manifold Bio is seeking an exceptional Senior Director of Biotherapeutics to help guide and mature ...

Merck & Co.

... Senior Director to contribute to our Company's protein therapeutic efforts from discovery through ... engineering, molecular biology, bioengineering, or related STEM field; Relevant experience that ...

previous pagenext page

Showing results 21-40

All JobsProtein Engineering JobsSenior Director Protein Engineering Jobs

Senior Director Protein Engineering information

See salary details

$35K

$120.8K

$192K

How much do senior director protein engineering jobs pay per year?

As of Aug 9, 2026, the average yearly pay for senior director protein engineering in the United States is $120,836.00, according to ZipRecruiter salary data. Most workers in this role earn between $75,000.00 and $156,000.00 per year, depending on experience, location, and employer.

What is the difference between Senior Director Protein Engineering vs Principal Scientist Protein Engineering?

AspectSenior Director Protein EngineeringPrincipal Scientist Protein Engineering
CredentialsAdvanced degree (PhD/MSc), extensive industry experience, leadership skillsPhD preferred, strong research background, technical expertise
Work EnvironmentLeadership role overseeing teams, strategic planning, cross-functional collaborationResearch-focused, hands-on scientific work, experimental design
Employer & Industry UsageBiotech, pharma companies, large R&D organizationsResearch institutes, biotech firms, pharma companies
Search & Comparison IntentUnderstanding leadership roles in protein engineeringTechnical expertise and research focus in protein engineering

The Senior Director Protein Engineering typically holds a leadership position, managing teams and setting strategic direction, while the Principal Scientist Protein Engineering is more research-focused, emphasizing technical expertise and experimental work. Both roles require advanced degrees and industry experience, but differ mainly in scope and responsibilities.

More about Senior Director Protein Engineering jobs
What cities are hiring for Senior Director Protein Engineering jobs? Cities with the most Senior Director Protein Engineering job openings:
What states have the most Senior Director Protein Engineering jobs? States with the most job openings for Senior Director Protein Engineering jobs include:
What job categories do people searching Senior Director Protein Engineering jobs look for? The top searched job categories for Senior Director Protein Engineering jobs are:
Senior Director Protein Engineering jobs near you
Infographic showing various Senior Director Protein Engineering job openings in the United States as of August 2026, with employment types broken down into 90% Full Time, 5% Part Time, 4% Contract, and 1% Nights. Highlights an 86% Physical, 4% Hybrid, and 10% Remote job distribution, with an average salary of $120,836 per year, or $58.1 per hour.

Senior AI Peptide and Protein Design Engineer

Ellison Medical Institute

Los Angeles, CA • On-site

$112K - $154K/yr

Full-time

Re-posted 28 days ago

Job description

Job Summary:
Ellison Medical Institute is a medical research and development center striving to enhance health and redefine cancer care. They are seeking a Senior AI Peptide and Protein Design Engineer to lead the design and delivery of next-generation therapeutics through AI-driven peptide and protein engineering, collaborating closely with interdisciplinary teams.
Responsibilities:
• Develop, deploy, and continuously improve computational pipelines for de novo peptide and protein design, including property prediction using data-driven and modeling approaches. Define robust benchmarking, performance metrics, and validation strategies
• Design and optimize novel peptide and protein therapeutics using sequence- and structure-based computational design methods, leveraging silico predictions to support lead identification and optimization
• Work directly with the peptide and protein production and characterization teams to experimentally test designs, interpret results, and incorporate feedback into iterative design cycles
• Collaborate with target biology and translational research teams to evaluate designs in biological context and support progression from concept to optimized lead candidates
• Mentoring junior scientists or contributing to hiring and team growth
• Maintain clear, reproducible documentation of methodologies, code, and results. Communicate findings effectively to scientific and leadership stakeholders
• Contribute to a high-performing scientific culture that values rigor, innovation, transparency, collaboration, accountability, and efficient execution
Qualifications:
Required:
• Ph.D. in Computational Peptide/Protein Design, Structural Biology, Protein Engineering, or a closely related field
• Postdoctoral or industry experience applying computational modeling to peptide or protein engineering, and a strong publication record or proven track record contributing to therapeutic development
• 5+ years of hands-on experience in peptide and protein design, modeling, and sequence/structure-function prediction, with proficiency in relevant macromolecular modeling software (i.e. AlphaFold, RoseTTAFold, RFdiffusion, RFpeptides, Boltz, ProteinMPNN)
• Demonstrated understanding of peptide and protein biology, including structure, folding, stability, and experimental constraints, gained through direct experimental work and/or close collaboration with wet-lab teams
• Strong analytical and problem-solving skills applied to complex biological and computational challenges
• Excellent teamwork, time management, documentation, and communication skills
• Proven ability to work effectively in interdisciplinary, cross-functional research environments
Company:
Ellison Medical Institute is a medical research and development center. Founded in 2016, the company is headquartered in Los Angeles, USA, with a team of 51-200 employees. The company is currently Growth Stage.

Apply